Laboratory of Biochemistry

Cancer cells acquire distinct malignant traits through alterations in intracellular molecules, such as genetic mutations, changes in gene expression, and modifications of nucleic acids and proteins. These molecular changes lead to a deviation from the normal cellular state.

Our laboratory investigates genes and non-coding RNAs aberrantly expressed in cancer cells and patients, and analyzes their roles in cancer biology. In addition to experimental research, public datasets and bioinformatics approaches are utilized to identify molecules implicated in cancer initiation and progression, with subsequent experimental validation of their functions. Some molecules involved in tumor development and progression are evolutionarily conserved, and elucidating their functions may provide insight into fundamental molecular mechanisms of life.

By examining cancer-associated molecular alterations at functional, expression, and evolutionary levels, the research aims to identify pivotal molecules underlying cancer progression, enhance understanding of cancer mechanisms, and uncover novel therapeutic targets.