Ken-ichi Nakashima, Naohito Abe, Masayoshi Oyama, Hiroko Murata, Makoto Inoue. Sulfur-containing spiroketals from Breynia disticha and evaluations of their anti-inflammatory effect.
Ken-ichi Nakashima, Marina Okamura, Imari Matsumoto, Nanae Kameda, Eiji Yamaguchi, Akichika Itoh, Makoto Inoue. Regulation of adipogenesis through retinoid X receptor and/or peroxisome proliferator‑activated receptor by designed lignans based on natural products in 3T3–L1 cells.
Ken-ichi Nakashima, Yuka Higuchi, Junko Tomida, Yoshiaki Kawamura, Makoto Inoue. Two new ɑ-pyrone derivatives from the endophytic Diaporthe sp. ECN371.
Genki Kiyama, Ken-ichi Nakashima, Kazumasa Shimada, Naoko Murono, Wataru Kakihana, Hideki Imai, Makoto Inoue, Takao Hirai. Transmembrane G protein-coupled receptor 5 signaling stimulates fibroblast growth factor 21 expression concomitant with up-regulation of the transcription factor nuclear receptor Nr4a1.
Ken-ichi Nakashima, Junko Tomida, Yoshiaki Kawamura, Makoto Inoue. A new chromone derivative from endophytic fungus Xylaria sp. ECN212.
Ken-ichi Nakashima, Junko Tomida, Tomoe Tsuboi, Yoshiaki Kawamura, Makoto Inoue. Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale.
Ken-ichi Nakashima, Eiji Yamaguchi, Chihaya Noritake, Yukari Mitsugi, Mayuki Goto, Takao Hirai, Naohito Abe, Eiji Sakai, Masayoshi Oyama, Akichika Itoh, Makoto Inoue. Discovery and SAR of natural-product-inspired RXR agonists with heterodimer selectivity to PPARδ-RXR.
Iclal Saracoglu, T. Suleimanov, N. Pashaeva, Z. Dogan, Makoto Inoue, Ken-ichi Nakashima. Iridoids from Veronica crista-galli from the Flora of Azerbaijan.
Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura, Makoto Inoue. Absolute configurations of talaromycones A and B, α-diversonolic ester, and aspergillusone B from endophytic Talaromyces sp. ECN211.
Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura, Makoto Inoue. Paraconiothins A−J: sesquiterpenoids from the endophytic fungus Paraconiothyrium brasiliense ECN258.
Sakiko Nishikawa, Yuka Itoh, Muneshige Tokugawa, Yasumichi Inoue, Ken-ichi Nakashima, Yuka Hori, Chiharu Miyajima, Kou Yoshida, Daisuke Morishita, Nobumichi Ohoka, Makoto Inoue, Hajime Mizukami, Toshiaki Makino, Hidetoshi Hayashi. Kurarinone from Sophora flavescens roots triggers ATF4 activation and cytostatic effects through PERK phosphorylation.
Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yoshiaki Kawamura, Makoto Inoue. Sesquiterpenes with new carbon skeletons from the basidiomycete Phlebia tremellosa.
Takao Hirai, Yuhei Mitani, Karen Kurumisawa, Wei Wang, Ken-ichi Nakashima, Makoto Inoue. Berberine stimulates fibroblast growth factor 21 by modulating the molecular clock component brain and muscle Arnt-like 1 in brown adipose tissue.
平居貴生, 高木三千代, 中島健一, 井上 誠. 脂肪細胞の褐色化に作用する天然物の探索とその制御機構の解析. (Review)
Wei Wang, Ken-ichi Nakashima, Takao Hirai, Makoto Inoue. Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor/liver X receptor heterodimers.
Wei Wang, Ken-ichi Nakashima, Takao Hirai, Makoto Inoue. Neuroprotective effect of naturally occurring RXR agonists isolated from Sophora tonkinensis Gagnep. on amyloid-β-induced cytotoxicity in PC12 cells.
Takao Hirai, Kohei Nomura, Rie Ikai, Ken-ichi Nakashima, Makoto Inoue. Baicalein stimulates fibroblast growth factor 21 expression by up-regulating retinoic acid receptor-related orphan receptor α in C2C12 myotubes.
Michiyo Takagi, Kazunori Kimura, Ken-ichi Nakashima, Takao Hirai, Makoto Inoue. Induction of beige adipocytes by naturally occurring β3-adrenoceptor agonist p-synephrine.
Junji Akaki, Shiori Tachi, Naoki Nakamura, Tetsuya Arai, Hiroo Yamasaki, Makoto Inoue, Toshiaki Makino. Promotive effect of Bofutsushosan (Fangfengtongshengsan) on lipid and cholesterol excretion in feces in mice treated with a high-fat diet.
Ken-ichi Nakashima, Junko Tomida, Tetsuro Kamiya, Takao Hirai, Yuji Morita, Hirokazu Hara, Yoshiaki Kawamura, Tetsuo Adachi, Makoto Inoue. Diaporthols A and B: Bioactive diphenyl ether derivatives from an endophytic fungus Diaporthe sp.
Michiyo Takagi, Kazunori Kimura, Ken-ichi Nakashima, Makoto Inoue. Ameliorative effect of panaxynol on the reduction in high-molecular-weight adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acids.
Hiroshi Kitamura, Natsuko Saito, Junpei Fujimoto, Ken-ichi Nakashima, Daisuke Fujikura. Brazilian propolis ethanol extract and its component kaempferol induce myeloid-derived suppressor cells from macrophages of mice in vivo and in vitro.
Ken-ichi Nakashima, Takumi Ogiwara, Takao Hirai, Toshiyuki Tanaka, Hiroko Murata, Kouichi Kaburagi, Yoshiaki Fujii-Kuriyama, Hidetoshi Hayashi, Makoto Inoue. Geronthoxanthone B from Maclura cochinchinensis var. gerontogea exhibits anti-inflammatory potential as an aryl hydrocarbon receptor agonist.
Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yuji Morita, Yoshiaki Kawamura, Makoto Inoue. Tubakialactones A–E, new polyketides from the endophytic fungus Tubakia sp. ECN-111.
Ken-ichi Nakashima, Junko Tomida, Masanori Tabata, Takao Hirai, Yuji Morita, Yoshiaki Kawamura, Makoto Inoue. A new chromone derivative from an endophytic fungus Xylaria sp. isolated from Ardisia crenata.
Ken-ichi Nakashima, Junko Tomida, Takao Hirai, Yuji Morita, Yoshiaki Kawamura, Makoto Inoue. A new isocoumarin derivative from an endophytic fungus Thielavia sp. isolated from Crassula ovata.
Ken-ichi Nakashima, Naohito Abe, Fang-Rong Chang, Makoto Inoue, Masayoshi Oyama. Pteleifoliols A–E, acetophenone di-C-glycosides and a benzopyran dimer from the leaves of Melicope pteleifolia.
Ken-ichi Nakashima, Hiroki Tanabe, Yoshiaki Fujii-Kuriyama, Hidetoshi Hayashi, Makoto Inoue. Atranorin and lecanoric acid antagonize TCDD-induced xenobiotic response element-driven activity, but not xenobiotic response element-independent activity.
Yuji Morita, Ken-ichi Nakashima, Kunihiko Nishino, Junko Tomida, Makoto Inoue, Yoshiaki Kawamura. Berberine is a novel type efflux inhibitor which attenuates the MexXY-mediated aminoglycoside resistance in Pseudomonas aeruginosa.
Ken-ichi Nakashima, Naohito Abe, Masayoshi Oyama, Makoto Inoue. Yuccalides A–C, three new phenolic compounds with spiro-structures from the roots of Yucca gloriosa.
Ken-ichi Nakashima, Toshiyuki Tanaka, Hiroko Murata, Kouichi Kaburagi, Makoto Inoue. Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity.
Makoto Inoue, Hiroki Tanabe, Ken-ichi Nakashima, Yukihiro Ishida, Hitoshi Kotani. Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.
Ken-ichi Nakashima, Tohru Murakami, Hiroki Tanabe, and Makoto Inoue. Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis.
Masayoshi Oyama, Ken-ichi Nakashima, Tetsuro Kamiya, Manami Haba, Tetsuro Ito, Hiroko Murata, Toshiyuki Tanaka, Tetsuo Adachi, Munekazu Iinuma, Takeshi Kinoshita. Flavonoids isolated from the leaves of Melicope triphylla and their extracellularsuperoxide dismutase-inducing activity.
Ken-ichi Nakashima, Masayoshi Oyama, Tetsuro Ito, Joko Ridho Witono, Dedy Darnaedi, Toshiyuki Tanaka, Jin Murata, Munekazu Iinuma. Novel zierane- and guaiane-type sesquiterpenes from the root of Melicope denhamii.
Kazuhiro Tsuruma, Hiroki Shimazaki, Ken-ichi Nakashima, Mika Yamauchi, Sou Sugitani, Masamitsu Shimazawa, Munekazu Iinuma, Hideaki Hara. Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo.
Ken-ichi Nakashima, Masayoshi Oyama, Tetsuro Ito, Yukihiro Akao, Joko Ridho Witono, Dedy Darnaedi, Toshiyuki Tanaka, Jin Murata, Munekazu Iinuma. Novel quinolinone alkaloids bearing a lignoid moiety and related constituents in the leaves of Melicope denhamii.
Ken-ichi Nakashima, Masayoshi Oyama, Tetsuro Ito, Joko Ridho Witono, Dedy Darnaedi, Toshiyuki Tanaka, Jin Murata, Munekazu Iinuma. Melicodenines A and B, novel Diels–Alder type adducts isolated from Melicope denhamii.
Ken-ichi Nakashima, Masayoshi Oyama, Tetsuro Ito, Hiroko Murata, Munekazu Iinuma. New furanocoumarins from the fruits of Melicope triphylla.
Ken-ichi Nakashima, Naohito Abe, Fumiko Kamiya, Tetsuro Ito, Masayoshi Oyama, Munekazu Iinuma. Novel flavonoids in dragon's blood of Daemonorops draco.