原 著 論 文

2024年
  1. Lee J.Y., Tokumoto M., Satoh M. Identification of Genes Affecting Cd Toxicity in HK-2 Cells. BPB Reports 7, 66-70, 2024. https://doi.org/10.1248/bpbreports.7.2_66
  2. Lee J.Y., Yoshida M., Satoh M., Watanabe C. Neurobehavioral effects of the exposure to mercury vapor and methylmercury during postnatal period on mice. Toxicol. Res. 40, 111–124, 2024. https://doi.org/10.1007/s43188-023-00210-3
2023年
  1. Tokumoto M., Lee J.Y., Fujiwara Y., Satoh M. Long-term exposure to cadmium causes hepatic iron deficiency through the suppression of iron-transport-related gene expression in the proximal duodenum. Toxics 11(7), 641, 2023. https://doi.org/10.3390/toxics11070641
  2. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Effect of cadmium on expression of BIRC family genes in HeLa cells. Fundam. Toxicol. Sci. 10, 133-136, 2023. https://doi.org/10.2131/fts.10.133

2022年
  1. Mori C., Lee J.Y., Tokumoto M., Satoh M. Cadmium Toxicity Is Regulated by Peroxisome Proliferator-Activated Receptor δ in Human Proximal Tubular Cells. Int. J. Mol. Sci. 3, 23, 8652, 2022. LINK

2021年
  1. Mori C., Lee, J.Y., Tokumoto, M., Satoh, M. Effect of Cadmium on the Expression of ABCB1 Transporter in Human Proximal Tubular Cells. BPB Reports 4, 74–77, 2021. LINK
  2. Lee J.Y., Mori C., Tokumoto M., Satoh M. Time-dependent changes in the gene expression levels in the mouse kidney by long-term exposure to cadmium. BPB Reports 4, 69-73, 2021. LINK
  3. Lee J.Y., Mori C., Tokumoto M., Satoh M. Changes in DNA-binding activity of transcription factors in the kidney of mice exposed to cadmium. J. Toxicol. Sci., 46, 125–129, 2021. LINK
  4. Lee J.Y., Tokumoto M., Satoh M. Cadmium toxicity mediated by the inhibition of SLC2A4 expression in human proximal tubule cells. FASEB J., 35, e21236, 2021. LINK

2020年
  1. Fujiwara Y.*, Lee J.Y.*, Banno H., Imai S., Tokumoto M., Hasegawa T., Seko Y., Nagase H., Satoh M. Cadmium induces iron deficiency anemia through the suppression of iron transport in the duodenum. Toxicol. Lett., 332, 130–139, 2020. *Co-first authors. LINK

2019年
  1. Lee, J.Y., Tokumoto, M., Hwang, G.W., Satoh, M. Effect of GATA transcription factors on cadmium toxicity in human proximal tubular cells. BPB Reports 2, 25–28, 2019. LINK

2018年
  1. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Comprehensive analysis of BIRC family gene expression changes by mercury compounds and arsenic exposure in neuroblastoma, kidney, and hepatic cells. BPB Reports 1, 20–24, 2018. PDF
  2. Lee J.Y., Tokumoto M., Hwang G.W., Kim M.S., Takahashi T., Naganuma A., Yoshida M., Satoh M. Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression. Toxics, 6, E48, 2018. PDF
  3. Ichinomiya M., Shimada A., Ohta N., Inouchi E., Ogihara K., Naya Y., Nagane M., Morita T., Satoh M. Demonstration of mitochondrial damage and mitophagy in cisplatin-mediated nephrotoxicity. Tohoku J. Exp. Med., 246, 1–8, 2018. PDF
  4. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Effect of heat shock protein gene expression on cadmium toxicity in human proximal tubular cells. Fundam. Toxicol. Sci., 5, 93–97, 2018. PDF
  5. Tokumoto M., Lee J.Y., Shimada A., Tohyama C., Satoh M. Glutathione has a more important role than metallothionein-I/II against inorganic mercury-induced acute renal toxicity. J. Toxicol. Sci., 43, 275–280, 2018. PDF
  6. Sarma S. N., Saleem A., Lee J.Y., Tokumoto M., Hwang G.W., Chan H.M., Satoh M. Effects of long-term cadmium exposure on urinary metabolite profiles in mice. J. Toxicol. Sci., 43, 89–100, 2018. PDF
  7. Kurita H., Hasegawa T., Seko Y., Nagase H., Tokumoto M., Lee J.Y., Satoh M. Effect of gestational cadmium exposure on fetal growth, polyubiquitinated protein and monoubiqutin levels in the fetal liver of mice. J. Toxicol. Sci., 43, 19–24, 2018. PDF
  8. Yoshida M., Lee J.Y., Satoh M., Watanabe C. Neurobehavioral effects of postnatal exposure to low-level mercury vapor and/or methylmercury in mice. J. Toxicol. Sci., 43, 11–17, 2018. PDF

2017年
  1. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Effect of chronic cadmium exposure on the gene expression of Birc family in the mouse kidney and liver. Fundam. Toxicol. Sci., 4, 275-278, 2017. PDF
  2. Tokumoto M., Shibuya K., Lee J.Y., Tohyama C., Satoh M. Effect of metallothionein on ethanol-induced hepatotoxicity in mice. Fundam. Toxicol. Sci., 4, 269-273, 2017. PDF
  3. Lee J.Y., Tokumoto M., Hwang G.W., Lee M.Y., Satoh M. Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity. Sci. Rep., 7, 17287, 2017. PDF


2016年
  1. Lee J.Y., Tokumoto M., Fujiwara Y., Hwang G.W., Lee M.Y., Satoh M. Sensitivity of MT-III null mice upon chronic exposure to cadmium. Fundam. Toxicol. Sci., 3, 285–289, 2016. PDF
  2. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Cadmium-induced protein ubiquitination in UBA80 knockdown HK-2 cells. Fundam. Toxicol. Sci., 3, 281–284, 2016. PDF
  3. Kurita H., Nagase H., Tokumoto M., Lee J.Y., Satoh M. DNA microarray analysis of fetal liver of C57BL/6J mice exposed to cadmium during gestation. Fundam. Toxicol. Sci., 3, 257–280, 2016. PDF
  4. Park J.M., Chang K.H., Park K.H., Choi S.J., Lee K., Lee J.Y., Satoh M., Song S.Y., Lee M.Y. Differential Effects between Cigarette Total Particulate Matter and Cigarette Smoke Extract on Blood and Blood Vessel. Toxicol. Res., 32, 353−358, 2016. PDF
  5. Yoshida M., Lee J.Y., Shimizu-Furusawa H., Satoh M., Watanabe C. Neurobehavioral toxicity related to the exposure of weaning mice to low-level mercury vapor and methylmercury and influence of aging. Fundam. Toxicol. Sci., 3, 185–193, 2016. PDF
  6. Hattori Y., Naito M., Satoh M., Nakatochi M., Naito H., Kato M., Takagi S., Matsunaga T., Seiki T., Sasakabe T., Suma S., Kawai S., Okada R., Hishida A., Hamajima N., Wakai K. Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies. Toxicol. Sci., 152, 181–193, 2016. PDF
  7. Lee J.Y., Tokumoto M., Fujiwara Y., Hasegawa T., Seko Y., Shimada A., Satoh M. Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity. Sci. Rep., 6, 21968, 2016. PDF
  8. Fujie T., Segawa Y., Kimura T., Fujiwara Y., Yamamoto C., Satoh M., Naka H., Kaji T. Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells. J. Toxicol. Sci. 41, 225–232, 2016. PDF
  9. Lee J.Y., Tokumoto M., Hattori Y., Fujiwara Y., Shimada A., Satoh M. Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes. Toxicol. Res. 32, 73–80, 2016. PDF
  10. Park J.M., Lee J.H., Na C.S., Lee D., Lee J.Y., Satoh M., Lee M.Y. Heartwood Extract of Rhus verniciflua Stokes and Its Active Constituent Fisetin Attenuate Vasoconstriction through Calcium-dependent Mechanism in Rat Aorta. Biosci. Biotechnol. Biochem., 80, 493–500, 2016. LINK

2015年
  1. Lee J.Y., Tokumoto M., Satoh M. The enhancement effect of HIST1H4C knockdown on cadmium toxicity in human proximal tubular cells. Fundam. Toxicol. Sci., 2, 259–262, 2015. PDF
  2. Lee J.Y., Tokumoto M., Fujiwara Y., Satoh M. Involvement of ubiquitin-coding genes in cadmium-induced protein ubiquitination in human proximal tubular cells. J. Toxicol. Sci. 40, 901–908, 2015. PDF

2014年
  1. Lee J.Y., Tokumoto M., Fujiwara Y., Lee M.Y., Satoh M. The involvement of GPRC5B in cadmium toxicity in HK-2 cells. Fundam. Toxicol. Sci., 1, 165–167, 2014. PDF
  2. Lee J.Y., Tokumoto M., Fujiwara Y., Lee M.Y., Satoh M. Effects of cadmium on the gene expression of SLC39A1 coding for ZIP1 protein. Fund. Toxicol. Sci., 1, 131–133, 2014. PDF
  3. Nakamura S., Shimazawa M., Inoue Y., Takata S., Ito Y., Tsuruma K., Ikeda T., Honda A., Satoh M., Hara H. Role of metallothioneins 1 and 2 in ocular neovascularization. Invest. Ophthalmol. Vis. Sci., 55, 6851–6860, 2014. LINK
  4. Tokumoto M., Lee J.Y., Fujiwara Y., Satoh M. Alteration of DNA binding activity of transcription factors in NRK-52E rat proximal tubular cells treated with cadmium. J. Toxicol. Sci., 39, 735–738, 2014. PDF
  5. Yoshida M., Honda A., Watanabe C., Satoh M., Yasutake A. Neurobehavioral changes in response to alterations in gene expression profiles in the brains of mice exposed to low and high levels of mercury vapor during postnatal development. J. Toxicol. Sci., 39, 561–570, 2014. PDF
  6. Imai S., Tokumoto M., Fujiwara Y., Hasegawa T., Seko Y., Lee J.Y., Nagase H., Satoh M. Gene expression differences in the duodenum of 129/Sv and DBA/2 mice compared with that of C57BL/6J mice. J. Toxicol. Sci., 39, 173–177, 2014. PDF

2013年
  1. Lee J.Y., Tokumoto M., Fujiwara Y., Satoh M. Gene expression analysis using DNA microarray in HK-2 human renal proximal tubular cells treated with cadmium. J. Toxicol. Sci., 38, 959–962, 2013. PDF
  2. Tokumoto M., Lee J.Y., Fujiwara Y., Uchiyama M., Satoh M. Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells. J. Toxicol. Sci.,38, 815–820, 2013. PDF
  3. Tokumoto M., Lee J.Y., Fujiwara Y., Satoh M. DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months. J. Toxicol. Sci., 38, 799–802, 2013. PDF
  4. Tsuji T., Naito Y., Takagi T., Kugai M., Yoriki H., Horie R., Fukui A., Mizushima K., Hirai Y., Katada K., Kamada K., Uchiyama K., Handa O., Konishi H., Yagi N., Ichikawa H., Yanagisawa R., Suzuki J.S., Takano H., Satoh M., Yoshikawa T. Role of metallothionein in murine experimental colitis. Int. J. Mol. Med., 31, 1037–1046, 2013. LINK
  5. Tokumoto M., Ohtsu T., Imai S, Honda A., Nagase H., Satoh M. DNA microarray analysis of hepatic gene expression in mice exposed to cadmium for 30 days. J. Toxicol. Sci., 38, 155–157, 2013. PDF
  6. Honda A., Watanabe C., Yoshida M., Nagase H., Satoh M. Microarray analysis of neonatal brain exposed to cadmium during gestation and lactation. J. Toxicol. Sci., 38, 151–153, 2013. PDF
  7. Yoshida M., Watanabe C., Honda A., Satoh M., Yasutake A. Emergence of delayed behavioral effects in offspring mice exposed to low levels of mercury vapor during the lactation period. J. Toxicol. Sci., 38, 1–6, 2013. PDF

2012年
  1. Mita M., Satoh M., Shimada A., Azuma S., Himeno S., Hara S. Metallothionein deficiency exacerbates chronic inflammation associated with carcinogenesis in stomach of mice infected with Helicobacter pylori. J. Toxicol. Sci., 37, 1275–1278, 2012. PDF
  2. Tsuruma K., Shimazaki H., Ohno Y., Inoue Y., Honda A., Imai S., Lee J.Y., Shimazawa M., Satoh M., Hara H. Metallothionein-III Deficiency Exacerbates Light-Induced Retinal Degeneration. Invest. Ophthalmol. Vis. Sci., 53, 7896–7903, 2012. LINK
  3. Kimura T., Yoshida K., Yamamoto C., Suzuki M., Uno T., Isobe M., Yasuike S., Satoh M., Kaji T., Uchiyama M. Bis (L-cysteinato) zincate (II) as a coordination compound that specifically induces methallothionein gene transcription without inducing cell-stress-related gene transcription. J. Inorg. Biochem., 117, 140–146, 2012. LINK
  4. Yasutake A, Yoshida M, Honda A, Watanabe C, Satoh M. Distribution of mercury in metallothionein-null mice after exposure to mercury vapor: amount of metallothionein isoform does not affect accumulation of mercury in the brain. J. Toxicol. Sci., 37, 765–771, 2012. PDF
  5. Fujiwara Y., Yamamoto C., Inagaki T., Satoh M., Kaji T. Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells. J. Toxicol. Sci., 37, 837–843, 2012. PDF
  6. Takahashi Y., Tsuruta S., Honda A., Fujiwara Y., Satoh M., Yasutake A. Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney. J. Toxicol. Sci., 37, 663–666, 2012. PDF
  7. Seo M., Kobayashi R., Okamura T., Ikeda K., Satoh M., Inagaki N., Nagai H., Nagase H. Enhancing effect of trichloroethylene and tetrachloroethylene on type I allergic responses in mice. J. Toxicol. Sci., 37, 439–445, 2012. PDF
  8. Nakazato K., Nakajima K., Nakano T., Kodaira T., Nakayama K., Satoh M., Nagamine T., Metallothionein (MT) 1/2 expression in MT 1/2 and MT 3 knock-out mice and Long-Evans Cinnamon (LEC) rats. J. Toxicol. Sci., 37, 169–175, 2012. PDF

2011年
  1. Yoshida M., Honda M., Watanabe C., Satoh M., Yasutake A. Neurobehavioral changes and alteration of gene expression in the brains of metallothionein-I/II null mice exposed to low levels of mercury vapor during postnatal development. J. Toxicol. Sci., 36, 539–547, 2011. PDF
  2. Yoshida M., Suzuki M., Satoh M., Yasutake A., Watanbe C. Neurobehavioral effects of combined prenatal exposure to low-level mercury vapor and methylmercury. J. Toxicol. Sci., 36, 73–80, 2011. PDF
  3. Tokumoto M., Fujiwara Y., Shimada A., Hasegawa T., Seko Y., Nagase H., Satoh M. Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo. J. Toxicol. Sci., 36, 191–200, 2011. LINK　〜平成24年度 日本毒性学会・田邊賞受賞論文〜　〜平成26年度 日本毒性学会・ファイザー賞受賞論文〜
  4. Hozumi I., Hasegawa T., Honda A., Ozawa K., Hayashi Y., Hashimoto K., Yamada M., Koumura A., Sakurai T., Kimura A., Tanaka Y., Satoh M., Inuzuka T. Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J. Neurol. Sci., 303 (1–2), 95–99, 2011. LINK
  5. Fujiwara Y., Banno H., Shinkai Y., Yamamoto C., Kaji T., Satoh M. Protective effect of pretreatment with cilostazol on cytotoxicity of cadmium and arsenite in cultured vascular endothelial cells. J. Toxicol. Sci., 36, 155–161, 2011. PDF
  6. Fujiwara Y., Honda A., Yamamoto C., Kaji T., Satoh M. DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium. J. Toxicol. Sci., 36, 141–143, 2011. PDF
  7. Shimizu Y., Fujishiro H., Matsumoto K., Sumi D., Satoh M., Himeno S. Chronic exposure to arsenite induces S100A8 and S100A9 expression in rat RBL-2H3 mast cells. J. Toxicol. Sci., 36, 135–139, 2011. PDF
  8. Tokumoto M., Ohtsu T., Honda A., Fujiwara Y., Nagase H., Satoh M. DNA microarray analysis of normal rat kidney epithelial cells treated with cadmium. J. Toxicol. Sci., 36, 127–129, 2011. PDF

2010年
  1. Itoh T., Nakai K., Satoh M., Satoh C., Kameo S., Nakagi Y., Saijo Y., Yoshida T., Naganuma A., Imai H., Satoh H. Effect of zinc deficiency on the behavior of metallothionein-I, II knockout mice. Biomed. Res. Trace Elem., 21, 204–213, 2010. LINK
  2. Ishiguro M., Mishiro K., Fujiwara Y., Chen H., Izuta H., Tsuruma K., Shimazawa M., Yoshimura S., Satoh M., Iwama T., Hara H. Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA. PLoS ONE, 5(12), e15178, 2010. LINK
  3. Matsumoto K., Fujishiro H., Satoh M., Himeno S. DNA microarray analysis of the liver of mice treated with cobalt chloride. J. Toxicol. Sci., 35, 935–939, 2010. LINK
  4. Kobayashi R., Ikemoto T., Seo M., Satoh M., Inagaki N., Nagai H., Nagase H. Enhancement of immediate allergic reactions by trichloroethylene ingestion via drinking water in mice. J. Toxicol. Sci., 35, 699–707, 2010. LINK
  5. Honda A., Komuro H., Shimada A., Hasegawa T., Seko Y., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y., Satoh M. Attenuation of cadmium-induced testicular injury in metallothionein-III null mice. Life. Sci., 87, 545–550, 2010. PDF　
  6. Tasaka S., Inoue K., Miyamoto K., Nakano Y., Kamata H., Shinoda H., Hasegawa N., Miyasho T., Satoh M., Takano H., Ishizuka A. Role of interleukin-6 in elastase-induced lung inflammatory changes in mice. Exp. Lung Res., 36, 362–372, 2010. Link
  7. Hozumi I., Kohmura A., Kimura A., Hasegawa T., Honda A., Hayashi Y., Hashimoto K., Yamada M., Sakurai T., Tanaka Y., Satoh M., Inuzuka T. High levels of copper, zinc, iron and magnesium but not calcium, in the cerebrospinal fluid of patients with Fahr's disease. Case Rep. Neurol., 2, 46–51, 2010. PDF
  8. Hirooka T., Fujiwara Y., Shinkai Y., Yamamoto C., Yasutake A., Satoh M., Eto K., Kaji T. Resistance of human brain microvascular endothelial cells in culture to methylmercury: Cell-density-dependent defense mechanisms. J. Toxicol. Sci., 35, 287–294, 2010. PDF
  9. Fujiwara Y., Honda A., Satoh M. DNA microarray gene expression analysis of human vascular endothelial cells exposed to arsenite. J. Toxicol. Sci., 35, 275–278, 2010. PDF
  10. Honda A., Komuro H., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y., Satoh M. Microarray analysis of the liver in metallothionein-III null mice treated with cadmium. J. Toxicol. Sci., 35, 271–273, 2010. PDF
  11. Takaishi M., Shimada A., Suzuki J.S., Satoh M., Nagase H. Involvement of metallothionein (MT) as a biological protective factor against carcinogenesis induced by benzo[a]pyrene (B[a]P). J. Toxicol. Sci., 35, 225–230, 2010. PDF 　
  12. Honda A., Komuro H., Hasegawa T., Seko Y., Shimada A., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y., Satoh M. Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity. J. Toxicol. Sci., 35, 209–215, 2010. PDF　〜平成23年度 日本毒性学会・田邊賞受賞論文〜
  13. Hirooka T., Fujiwara Y., Minami Y., Ishii A., Ishigooka M., Shinkai Y., Yamamoto C., Satoh M., Yasutake A., Eto K., Kaji T. Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes. Toxicol. In Vitro, 24, 835–841, 2010. PDF
  14. Takaishi M., Satoh M., Suzuki J.S., Nagase H. Preventive effect of preinduction of metallothionein on mutagenicity caused by benzo[a]pyrene. J. Health Sci., 56, 65–71, 2010. PDF

2009年
  1. Hashimoto K., Honda A., Hayashi Y., Inuzuka T., Satoh M., Hozumi I. DNA microarray analysis of transcriptional responses of mouse spinal cords to physical exercise. J. Toxicol. Sci., 34, 445–448, 2009. LINK
  2. Takaishi M., Sawada M., Shimada A., Suzuki S.J., Satoh M., Nagase H. Protective role of metallothionein in benzo[a]pyrene-induced DNA damage. J. Toxicol. Sci., 34, 449–458, 2009. LINK
  3. Koumura A., Hamanaka J., Shimazawa M., Honda A., Tsuruma K., Uchida Y., Hozumi I., Satoh M., Inuzuka T., Hara H. Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia. Brain Res., 1292, 148–154, 2009.
  4. Fujiwara Y., Kitagawa T., Shinkai Y., Kaji T., Satoh M. Cilostazol induces metallothionein expression in vascular cells. Yakugaku Zasshi, 129, 1415–1422, 2009. LINK
  5. Hirooka T., Fujiwara Y., Inoue S., Shinkai Y., Yamamoto C., Satoh M., Yasutake A., Eto K., Kaji T. Suppression of fibroblast growth factor-2 expression: Possible mechanism underlying the methylmercury-induced inhibition of repair of wounded monolayers of cultured human brain microvascular endothelial cells. J. Toxicol. Sci., 34, 433–439, 2009. LINK
  6. Koumura A., Kakefuda K., Honda A., Ito Y., Tsuruma K., Shimazawa M., Uchida Y., Hozumi I., Satoh M., Inuzuka T., Hara H. Metallothionien-3 deficient mice exhibit abnormalities of psychological behaviors. Neurosci. Lett., 467, 11–14, 2009. LINK

2008年
  1. Shibuya K., Nishimura N., Suzuki J.S., Tohyama C., Naganuma A., Satoh M. Role of metallothionein as a protective factor against radiation carcinogenesis. J. Toxicol. Sci., 33, 651–655, 2008. LINK
  2. Seo M., Yamagiwa T., Kobayashi R., Ikeda K., Satoh M., Inagaki N., Nagai H., Nagase H. Augmentation of antigen-stimulated allergic responses by a small amount of trichloroethylene ingestion from drinking water. Regul. Toxicol. Pharmacol., 52, 140–146, 2008. LINK
  3. Ohtani-Kaneko R., Tazawa H., Yokosuka M., Yoshida M., Satoh M., Watanabe C. Suppressive effects of cadmium on neurons and affected proteins in cultured developing cortical cells. Toxicology, 253, 110–116, 2008. LINK
  4. Fujiwara Y., Yamamoto C., Hirooka T., Terada N., Satoh M., Kaji T. Arsenite but not arsenate inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells. J. Toxicol. Sci., 33, 487–492, 2008. LINK
  5. Shibuya K., Suzuki J.S., Kito H., Naganuma A., Tohyama C., Satoh M. Protective role of metallothionein in bone marrow injury caused by X-irradiation. J. Toxicol. Sci., 33, 479–484, 2008. LINK　〜平成21年度 日本毒性学会・田邊賞受賞論文〜
  6. Seo M., Yamagiwa T., Kobayashi R., Ikeda K., Satoh M., Inagaki N., Nagai H., Nagase H. A small amount of tetrachloroethylene ingestion from drinking water accelerates antigen-stimulated allergic responses. Immunobiology, 213, 663–669, 2008. LINK
  7. Yoshida M., Shimizu N., Suzuki M., Watanabe C., Satoh M., Mori K., Yasutake A. Emergence of delayed methylmercury toxicity after perinatal exposure in metallothionein-null and wild-type C57BL mice. Environ. Health Perspect., 116, 746–751, 2008. LINK
  8. Mita M., Satoh M., Shimada A., Okajima M., Azuma S., Suzuki J.S., Sakabe K., Hara S., Himeno S. Metallothionein is a crucial protective factor against Helicobacter pylori-induced gastric erosive lesions in a mouse model. Am. J. Physiol. Gastrointest. Liver Physiol., 294, G877–884, 2008. LINK
  9. Kotani Y., Nakajima Y., Hasegawa T., Satoh M., Nagase H., Shimazawa M., Yoshimura S., Iwama T., Hara H. Propofol exerts greater neuroprotection with disodium edetate than without it. J. Cereb. Blood Flow Metab., 28, 354–366, 2008. PDF
  10. Seo M., Ikeda K., Okamura T., Kida K., Satoh M., Inagaki N., Nagai H., Nagase H. Enhancing effect of chlorinated organic solvents on histamine release and inflammatory mediator production. Toxicology, 243, 75–83, 2008. PDF
  11. Fujiwara Y., Mikami C., Nagai M., Yamamoto C., Hirooka T., Satoh M., Kaji T. Homocysteine Inhibits Proteoglycan Synthesis in Cultured Bovine Aortic Smooth Muscle Cells. J. Health Sci., 54, 56–65, 2008. LINK

2007年
  1. Hasegawa T., Satoh M., Seko Y. Metallothionein levels of carps in the liver of Yamanashi Prefecture. Jpn. J. Environ. Toxicol., 10, 59–67, 2007. LINK
  2. Wakida K., Shimazawa M., Hozumi I., Satoh M., Nagase H., Inuzuka T., Hara H. Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia. Neuroscience, 148, 105–114, 2007. LINK
  3. Kobayashi K., Kuroda J., Shibata N., Hasegawa T., Seko Y., Satoh M., Tohyama C., Takano H., Imura N., Sakabe K., Fujishiro H., Himeno S. Induction of metallothionein by manganese is completely dependent on interleukin-6 production. J. Pharmacol. Exp. Ther., 320, 721–727, 2007. LINK

2006年
  1. Fujimaki H., Kurokawa Y., Yamamoto S., Satoh M. Distinct requirements for interleukin-6 in airway inflammation induced by diesel exhaust in mice. Immunopharmacol. Immunotoxicol., 28, 703–714, 2006. LINK
  2. Kobayashi K., Himeno S., Satoh M., Kuroda J., Shibata N., Seko Y., Hasegawa T. Pentavalent vanadium induces hepatic metallothionein through interleukin-6-dependent and -independent mechanisms. Toxicology, 228, 162–170, 2006. LINK
  3. Mori K., Yoshida K., Hoshikawa S., Ito S., Yoshida M., Satoh M., Watanabe C. Effects of perinatal exposure to low doses of cadmium or methylmercury on thyroid hormone metabolism in metallothionein-deficient mouse neonates. Toxicology, 228, 77–84, 2006. LINK
  4. Suemori S., Shimazawa M., Kawase K., Satoh M., Nagase H., Yamamoto T., Hara H. Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice. Invest. Ophthalmol. Vis. Sci., 47, 3975–3982, 2006. PDF
  5. Adachi T., Satoh M., Pramanik R., Kuroda S., Ishido M., Kunimoto M. Region-dependent differences and alterations of protective thiol compound levels in cultured astrocytes and brain tissues. Biol. Pharm. Bull., 29, 1466–1469, 2006. PDF
  6. Fujishiro H., Okugaki S., Nagao S., Satoh M., Himeno S. Characterization of gene expression profiles of metallothionein-null cadmium-resistant cells. J. Health Sci., 52, 292–299, 2006. PDF
  7. Hayashi Y., Hashizume T., Wakida K., Satoh M., Uchida Y., Watabe K., Matsuyama Z., Kimura A., Inuzuka T., Hozumi I. Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population. Amyotroph. Lateral. Scler., 7, 22–26, 2006. LINK
  8. Inoue K., Takano H., Shimada A., Wada E., Yanagisawa R., Sakurai M., Satoh M., Yoshikawa T. Role of metallothionein in coagulatory disturbance and systemic inflammation induced by lipopolysaccharide in mice. FASEB J., 20, 533–535, 2006. LINK
  9. Yoshida M., Watanabe C., Kishimoto M., Yasutake A., Satoh M., Sawada M., Akama Y. Behavioral changes in metallothionein-null mice after the cessation of long-term, low-level exposure to mercury vapor. Toxicol. Lett., 161, 210–218, 2006. LINK

2005年
  1. Kobayashi K., Shida R., Hasegawa T., Satoh M., Seko Y., Tohyama C., Kuroda J., Shibata N., Imura N., Himeno S. Induction of hepatic metallothionein by trivalent cerium: role of interleukin 6. Biol. Pharm. Bull., 28, 1859–1863, 2005. PDF
  2. Shimada A., Nagayama Y., Morita T., Yoshida M., Suzuki S.J., Satoh M., Tohyama C. Localization and role of metallothioneins in the olfactory pathway after exposure to mercury vapor. Exp. Toxicol. Pathol., 57, 117–125, 2005. LINK
  3. Yoshida M., Watanabe C., Horie K., Satoh M., Sawada M., Shimada A. Neurobehavioral changes in metallothionein-null mice prenatally exposed to mercury vapor. Toxicol. Lett., 155, 361–368, 2005. LINK

2004年
  1. Shimada A., Yamamoto E., Morita T., Yoshida M., Suzuki J., Satoh M., Tohyama C. Ultrastructural demonstration of mercury granules in the plasenta of metallothionein-null pregnant mice after exposure to mercury vapor. Toxicol. Pathol., 32, 519–526, 2004. PDF
  2. Yasutake A., Sawada M., Shimada A., Satoh M., Tohyama C. Mercury accumulation and its distribution on metallothionein in mouse brain after sub-chronic pulse exposure to mercury vapor. Arch. Toxicol., 78, 489–495, 2004. LINK
  3. Jia G., Sone H., Nishimura N., Satoh M., Tohyama C. Metallothionein (I/II) suppresses genotoxicity caused by dimethylarsinic acid. Int. J. Oncol., 25, 325–333, 2004. LINK
  4. Naito Y., Takagi T., Uchiyama K., Kuroda M., Kokura S., Ichikawa H., Yanagisawa R., Inoue K., Takano H., Satoh M., Yoshida N., Okanoue T., Yoshikawa T. Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice. Int. J. Mol. Med., 14, 191–196, 2004. LINK
  5. Yoshida M., Watanabe C., Satoh M., Yasutake A., Sawada M., Ohtsuka Y., Akama Y., Tohyama C. Susceptibility of metallothionein-null mice to the behavioural alterations caused by exposure to mercury vapour at human-relevant concentration. Toxicol. Sci., 80, 69–73, 2004. PDF
  6. Kondo Y., Himeno S., Satoh M., Naganuma A., Nishimura T., Imura N. Citrate enhances the protective effect of orally administered bismuth subnitrate against the nephrotoxicity of cis-diamminedichloroplatinum. Cancer Chemother. Pharmacol., 55, 33–38, 2004. LINK

2003年
  1. Kondo Y., Yamagata K., Satoh M., Himeno S., Imura N., Nishimura T. Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein. J. Urol., 170, 2467–2470, 2003. LINK
  2. Suzuki J.S., Nishimura N., Zhang B., Kobayashi S., Satoh M., Tohyama C. Metallothionein deficiency enhances skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracen and 12-O-tetradecanoylphorbol-13-acetate in metallothionein-null mice. Carcinogenesis, 24, 1123–1132, 2003. PDF
  3. Murata M., Nishimura N., Zhang B., Satoh M., Tohyama C. Interleukin-6 protects skin legion caused by 7,12-dimethylbenz[a]anthracene. J. Vet. Med. Sci., 65, 511–513, 2003. LINK

2002年
  1. Yoshida M., Satoh M., Yasutake A., Yamamoto E., Shimada A., Tohyama C. Maternal-to-fetus transfer of mercury in metallothionein-null pregnant mice after exposure to mercury vapor. Toxicology, 175, 215–222, 2002. LINK

2001年
  1. Fukada K., Nagano S., Satoh M., Tohyama C., Nakanishi T., Shimizu A., Yanagihara T., Sakoda S. Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice. Eur. J. Neurosci., 14, 2932–2036, 2001. LINK
  2. Nishimura N., Miyabara Y., Suzuki J.S., Sato M., Yonemoto J., Satoh M., Aoki Y., Tohyama C. Induction of Metallothionein in the Livers of Female Sprague Dawley Rats Treated with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Life Sci., 69, 1291–1303, 2001. LINK
  3. Nagano S., Satoh M., Sumi H., Fujimura H., Tohyama C., Yanagihara T., Sakoda S. Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner. Eur. J. Neurosci., 13, 1363–1370, 2001. LINK
  4. Shibutani M., Mitsumori K., Satoh S., Hiratsuka H., Satoh M., Sumiyoshi M., Nishijima M., Katsuki Y., Suzuki J., Nakagawa J., Akagi T., Imazawa T., Ando M. Relationship between toxicity and cadmium accumulation in rats given low amounts of cadmium chloride or cadmium-polluted rice for 22 months. J. Toxicol. Sci., 26, 337–358, 2001. PDF

2000年
  1. Molotkov A., Satoh M., Tohyama C. Induction of hepatic metallothioneins in tumour-bearing IL-6-null mice. Oncol. Res., 12, 169–172, 2000. LINK
  2. Shibutani M., Mitsumori K., Niho N., Satoh S., Hiratsuka H., Satoh M., Sumiyoshi M., Nishijima M., Katsuki Y., Suzuki J., Nakagawa J., Ando M. Assessment of renal toxicity by analysis of regeneration of tubular epithelium in rats given low-dose cadmium chloride or cadmium-polluted rice for 22 months. Arch. Toxicol., 74, 571–577, 2000. LINK
  3. Satoh M., Shimada A., Zhang B., Tohyama C. Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice. Biochem. Pharmacol., 60, 1729–1734, 2000. LINK
  4. Satoh M., Naganuma A., Imura N. Modulation of adriamycin toxicity by tissue-specific induction of metallothionein synthesis in mice. Life Sci., 67, 627–634, 2000. LINK
  5. Takano H., Satoh M., Shimada A., Sagai M., Yoshikawa T., Tohyama C. Cytoprotection by metallothionein against gastroduodenal mucosal injury caused by ethanol in mice. Lab. Invest., 80, 371–377, 2000. PDF
  6. Toyoda H., Mizushima T., Satoh M., Iizuka N., Nomoto A., Chiba H., Mita M., Naganuma A., Imura N. HeLa cell transformants overproducing mouse metallothionein show in vivo resistance to cis-platinum in nude mice. Jpn. J. Cancer Res., 91, 91–98, 2000. PDF
  7. Nishimura N., Reeve V. E., Nishimura H., Satoh M., Tohyama C. Cutaneous metallothionein induction by ultraviolet B irradiation in interleukin-6-null mice. J. Invest. Dermatol., 114, 343–348, 2000. PDF
  8. Molotkov A., Nishimura N., Satoh M., Tohyama C. Role of IL-6 in the induction of hepatic metallothionein in mice after partial hepatectomy. Life Sci., 66, 963–970, 2000. LINK

1999年
  1. Yoshida M., Satoh M., Yasutake A., Shimada A., Sumi Y., Tohyama C. Distribution and retention of mercury in metallothionein-null mice after exposure to mercury vapor. Toxicology, 139, 129–136, 1999. LINK
  2. Hiratsuka H., Satoh S., Satoh M., Nishijima M., Katsuki Y., Suzuki J., Nakagawa J., Sumiyoshi M., Shibutani M., Mitsumori K., Tanaka-Kagawa T., Ando M. Tissue distribution of cadmium in rats given minimum amounts of cadmium-polluted rice or cadmium chliride for 8 months. Toxicol. Appl. Pharmacol., 160, 183–191, 1999. PDF
  3. Yasutake A., Satoh M., Tohyama C., Hirayama K. Selective and simple quantification of metallothionein III in mouse brain. J. Health Sci., 45: 222–225, 1999. PDF
  4. Yoshida M., Satoh M., Shimada A., Yasutake A., Sumi Y., Tohyama C. Pulmonary toxicity caused by acute exposure to mercury vapor is enhanced in metallothionein-null mice. Life Sci., 64, 1861–1867, 1999. PDF
  5. Nishimura N., Tohyama C., Satoh M., Nishimura H., Reeve V. E. Defective immune response and severe skin damage following UVB-irradiation in interleukin-6-deficient mice. Immunology, 97, 77–83, 1999. PDF
  6. Zhang B., Satoh M., Tohyama C. A protective role of metallothionein in acetaminophen-caused liver toxicity via oxidative stress. J. Health Sci., 45, 15–19, 1999. PDF

1998年
  1. Molotkov A., Satoh M., Tohyama C. Tumor growth and food intake in interleukin-6 gene knock-out mice. Cancer Lett., 132, 187–192, 1998. LINK
  2. Miura N, Satoh M., Imura N., Naganuma A. Protective effect of bismuth nitrate against injury to the bone marrow by γ-irradiation in mice: possible involvement of induction of metallothionein synthesis. J. Pharmacol. Exp. Ther., 286, 1427–1430, 1998. LINK
  3. Zhang B., Satoh M., Nishimura N., Suzuki J. S., Sone H., Aoki Y., Tohyama C. Metallothionein deficiency promotes mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene. Cancer Res., 58, 4044–4046 1998. PDF
  4. Okazaki Y., Miura N., Satoh M., Imura N., Naganuma A. Metallothionein-mediated resistance to multiple drugs can be induced by several anticancer drugs in mice. Biochem. Biophys. Res. Commun., 245, 815–818, 1998. LINK

1997年
  1. Satoh M., Nishimura N. Kanayama Y., Naganuma A., Suzuki T., Tohyama C. Enhanced renal toxicity by inorganic mercury in metallothionein-null mice. J. Pharmacol. Exp. Ther., 283, 1529–1533, 1997. LINK
  2. Shibuya K., Cherian M. G., Satoh M. Sensitivity to radiation treatment and changes in metallothionein synthesis in transplanted murine tumor. Radiat. Res., 148, 235–239, 1997. LINK
  3. Satoh M., Aoki Y., Tohyama C. Protective role of metallothionein in renal toxicity of cisplatinum. Cancer Chemother. Pharmacol., 40, 358–362, 1997. LINK

1996年
  1. Nakagawa I., Satoh M., Naganuma A., Imura N. Role of metallothionein in protection against renal oxidative stress induced by cis-diamminedichloroplatinum (II) in glutathione-depleted mice. Tohoku J. Exp. Med., 179, 11–21, 1996. PDF
  2. Tohyama C., Satoh M., Kodama N., Nishimura H., Choo A., Michalska A., Kanayama Y., Naganuma A. Reduced retention of cadmium in the liver of metallothionein-null mice. Environ. Toxicol. Pharmacol., 1, 213–216, 1996. LINK
  3. Satoh M., Tsuji Y., Watanabe Y., Okonogi H., Suzuki Y., Nakagawa M., Shimizu H. Metallothionein content increased in the liver of mice exposed to magnetic fields. Arch. Toxicol., 70, 315–318, 1996. LINK

1995年
  1. Murata R., Nishimura Y., Abe M., Satoh M. Manganese chloride treatment does not protect against acute radiation injury of skin or crypt cells. Radiat. Res., 143, 316–319, 1995. LINK
  2. Shibuya K., Satoh M., Muraoka M., Watanabe Y., Oida M., Shimizu H. Induction of metallothionein synthesis in transplanted murine tumors by X-irradiation. Radiat. Res., 143, 54–57, 1995. LINK

1994年
  1. Satoh M., Cherian M. G., Imura N., Shimizu H. Modulation of resistance to anticancer drugs by inhibition of metallothionein synthesis. Cancer Res., 54, 5255–5257, 1994. PDF

1993年
  1. Satoh M., Kondo Y., Mita M., Nakagawa I., Naganuma A., Imura N. Prevention of carcinogenicity of anticancer drugs by metallothionein induction. Cancer Res., 53, 4767–4768, 1993. PDF
  2. Satoh M., Kloth D. M., Kadhim S. A.,Chin J. L., Naganuma A., Imura N., Cherian M. G. Modulation of both cisplatin nephrotoxicity and drug resistance in murine bladder tumor by controlling metallothionein synthesis. Cancer Res., 53, 1829–1832, 1993. PDF
  3. Satoh M., Tsuchiya T., Kumada Y., Naganuma A., Imura N. Protection against lethal toxicity of various anticancer drugs by preinduction of metallothionein synthesis in mice. J. Trace Elem. Exp. Med., 6, 41–44, 1993.

1992年
  1. Kondo Y., Satoh M., Imura N., Akimoto M. Tissue-specific induction of metallothionein by bismuth as a promising protocol for chemotherapy with repeated administration of cis-diamminedichroloplatinum (II) against bladder tumor. Anticancer Res., 12, 2303–2308, 1992. LINK
  2. Chan H. M., Satoh M., Zalups R. K., Cherian M. G. Exogenous metallothionein and renal toxicity of cadmium and mercury in rats. Toxicology, 76, 15–26, 1992. LINK
  3. Satoh M., Naganuma A., Imura N. Effect of coadministration of selenite on the toxicity and antitumor activity of cis-diamminedichloroplatinum (II) given repeatedly to mice. Cancer Chemother. Pharmacol., 30, 439–443, 1992. LINK
  4. Satoh M., Naganuma A., Imura N. Effect of preinduction of metallothionein on paraquat toxicity in mice. Arch. Toxicol., 66, 145–148, 1992. LINK

1991年
  1. Kondo Y., Satoh M., Imura N., Akimoto M. Effect of bismuth nitrate given in combination with cis-diamminedichloroplatinum (II) on the antitumor activity and renal toxicity of the latter in nude mice inoculated with human bladder tumor. Cancer Chemother. Pharmacol., 29, 19–23, 1991. LINK

1989年
  1. Satoh M., Miura N., Naganuma A., Matsuzaki N., Kawamura E., Imura N. Prevention of adverse effects of g-ray irradiation by metallothionein induction by bismuth subnitrate in mice. Eur. J. Cancer Clin. Oncol., 25, 1727–1731, 1989. LINK
  2. Satoh M., Naganuma A., Imura N. Optimum schedule of selenium administration to reduce lethal and renal toxicities of cis-diamminedichloroplatinum in mice. J. Pharmacobio-Dyn., 12, 246–253, 1989. PDF

1988年
  1. Satoh M., Naganuma A., Imura N. Involvement of cardiac metallothionein in prevention of adriamycin induced lipid peroxidation in the heart. Toxicology, 53, 231–237, 1988. LINK
  2. Satoh M., Naganuma A., Imura N. Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination. Cancer Chemother. Pharmcol., 21, 176–178, 1988. LINK
  3. Naganuma A., Satoh M., Imura N. Specific reduction of toxic side effects of adriamycin by induction of metallothionein in mice. Jpn. J. Cancer Res., 79, 406–411, 1988. PDF

1987年
  1. Shibuya K., Satoh M., Hasegawa T., Naganuma A., Imura N. Protective effect of Chinese medicine on toxic side effects of cis-diamminedichloroplatinum in mice. YAKUGAKU ZASSHI, 107, 511–516, 1987. PDF
  2. Satoh M., Naganuma A., Imura N. Deficiency of selenium intake enhances manifestation of renal toxicity of cis-diamminedichloroplatinum in mice. Toxicol. Lett., 38, 155–160, 1987. LINK
  3. Naganuma A., Satoh M., Imura N. Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice. Cancer Res., 47, 983–987, 1987. PDF

1985年
  1. Naganuma A., Satoh M., Imura N. Protective effect of metallothionein inducing metals on lethal toxicity of cis-diamminedichloroplatinum in mice. Toxicol. Lett., 24, 203–207, 1985. LINK

1984年
  1. Naganuma A., Satoh M., Imura N. Effect of copper pretreatment on toxicity and antitumor activity of cis-diamminedichloroplatinum in mice. Res. Commun. Chem. Pathol. Pharmacol., 46, 265–270, 1984. LINK
  2. Naganuma A., Satoh M., Imura N. Effect of selenite on renal toxicity and antitumor activity of cis-diamminedichloroplatinum in mice inoculated with ehrlich ascites tumor cell. J. Pharmacobio-Dyn., 7, 217–220, 1984. PDF

1983年
  1. Naganuma A., Satoh M., Yokoyama M., Imura N. Selenium efficiently depressed toxic side effect of cis-diamminedichloroplatinum. Res. Commun. Chem. Pathol. Pharmacol., 42, 127–134, 1983. LINK