Research Fields

Organic and Medicinal Chemistry

Topics of research
  • Synthesis, molecular structure and reactivity of novel hypervalent compounds having group 15 and 16 elements
  • Synthesis and property of novel heterocyclic compounds containing main group elements
  • Bio-organometallics: Synthesis and bioactivity of organometallic compounds
  • Kitamura Y, Matsumura M, Kato Y, Murata Y, Yasuike S. Cascade synthesis of 4-arylcoumarins: Pd-catalyzed arylations and cyclizations with (E)-ethyl 3-(2-hydroxyaryl)acrylates and triarylantimony difluorides. Eur. J. Org. Chem., 2020, 1652-1657 (2020). Selected as Very Important Paper (VIP).
  • Murata Y, Terazoe A, Kiba M, Kitamura Y, Matsumura M, Yasuike S. Liebeskind-Srogl-type cross-coupling reaction of azole-2-thiones with triarylbismuthines: Synthesis of 2-arylazoles. Tetrahedron Lett., 61, 152152 (2020).
  • Murata Y, Asano S, Kato R, Kitamura Y, Matsumura M, Yasuike S. Synthesis of 2-(arylsulfenyl)azoles by copper-catalyzed S-arylation of azole-2-thiones with triarylbismuthines. Catal. Commun., 132, 105808 (2019).
  • Kitamura Y, Murata Y, Oguri A, Matsumura M, Kakusawa N, Naka H, Yasuike S. Pd-catalyzed β-selective C-H arylation of thiophenes with triarylantimony difluorides. Asian J. Org. Chem., 8, 138-143 (2019).
  • Kondo K, Matsumura M, Kanasaki K, Murata Y, Kakusawa N, Yasuike S. Synthesis of 2-aryl-3-(arylselanyl)imidazo[1,2-a]pyridines: copper-catalyzed one-pot, two-step Se-arylation of selenium with imidazopyridines and triarylbismuthanes. Synthesis, 50, 2200-2210 (2018). Highlighted as a Front Cover.

Bioorganic Chemistry

Topics of research
  • Drug discovery based on photophysical chemistry
  • Development of photofunctional organic compounds
  • Koga N, Tanioka M, Kamino S, Sawada D. Morpholine-Substituted Rhodamine Analog with Multi-Configurational Switches for Optical Sensing of pH Gradient under Extreme Acidic Environments. Chem. Eur. J., DOI 10.1002/chem.202004254.
  • Harada M, Tanioka M, Muranaka A, Aoyama T, Kamino S, Uchiyama M. A remarkably air-stable quinodimethane radical cation. Chem. Commun., 56, 9565-9568 (2020).
  • Tanioka M, Kamino S, Koga N, Sawada D. Stepwise structural and fluorescent colour conversion in rhodamine analogues based on light and acid stimulations. J. Mater. Chem. C, 8, 543-549 (2020).
  • Okamoto Y, Tanioka M, Muranaka A, Miyamoto K, Aoyama T, Ouyang X, Kamino S, Sawada D, Uchiyama M. Stable Thiele's Hydrocarbon Derivatives Exhibiting Near- Infrared Absorption/Emission and Two-Step Electrochromism. J. Am. Chem. Soc., 140, 17857-17861, (2018).
  • Fukino N, Kamino S, Takahashi M, Sawada D. Synthesis of Aminobenzopyranoxanthene with Nitrogen-Containing Fused-Rings. J. Org. Chem., 82, 13626-13631 (2017).

Medicinal Resources

Topics of research
  • Pharmacological and biochemical analysis of Kampo medicines effective for lifestyle-related and aging-associated diseases
  • Developmemt of natural compound-derived therapeuitc agents for lifestyle-related and chronic inflammatory/allergic diseases
  • Application of naturally occurring various nuclear receptor agonists to prevention/treatment of lifestyle-related diseases
  • Nakashima K, Yamaguchi E, Noritake C, Mitsugi Y, Goto M, Hirai T, Abe N, Sakai E, Oyama M, Itoh A, Inoue M. Discovery and SAR of Natural-Product-Inspired RXR Agonists with Heterodimer Selectivity to PPARδ-RXR. ACS Chem. Biol., 15, 1526-1534 (2020).
  • Nakashima K, Tomida J, Hirai T, Kawamura Y, Inoue M. Absolute configurations of talaromycones A and B, α-diversonolic ester, and aspergillusone B from endophytic Talaromyces sp. ECN211. Beilstein J. Org. Chem., 16, 290-296 (2020).
  • Hirai T, Mitani Y, Kurumisawa K, Nomura K, Wang W, Nakashima KI, Inoue M. Berberine stimulates fibroblast growth factor 21 by modulating the molecular clock component brain and muscle Arnt-like 1 in brown adipose tissue. Biochem. Pharmacol., 164, 165-176 (2019).
  • Wang W, Nakashima K, Hirai T, Inoue M. Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep via retinoid X receptor/liver X receptor heterodimers. J. Nat. Med., 73, 419-430 (2019).
  • Takagi M, Kimura K, Nakashima K, Hirai T, Inoue M. Induction of beige adipocytes by naturally occurring β3-adrenoceptor agonist p-synephrine. Eur. J. Pharmacol., 836, 67-74 (2018).

Analytical Chemistry and Biophysics

Topics of research
  • Molecular mechanism of immune responses
  • Molecular mechanism of allergic reaction
  • Crosstalk between immune and nervous systems
  • Gene transfection mediated by cationic liposomes
  • Suzuki R, Inoh Y, Yokawa S, Furuno T, Hirashima N. Receptor dynamics regulates actin polymerization state through phosphorylation of cofilin in mast cells. Biochem. Biophys. Res. Commun., 534, 714-719 (2021)
  • Inoh Y, Tsuchiya Y, Nakanishi Y, Yokawa S, Furuno T. Involvement of intracellular caveolin-1 distribution in the suppression of antigen-induced mast cell activation by cationic liposomes. Cell Biol. Int., 44, 1068-1075(2020)
  • Inoh Y, Hirose T, Yokoi A, Yokawa S, Furuno T. Effects of lipid composition in cationic liposomes on suppression of mast cell activation. Chem. Phys. Lipids, 231, 104948 (2020)
  • Suzuki R, Inoh Y, Yokawa S, Suzuki R, Furuno T, Hirashima N. Monomer hapten and hapten-specific IgG inhibit mast cell activation evoked by multivalent hapten with different mechanisms. Eur. J. Immunol., 49, 2172-2183 (2019)
  • Shiki A, Inoh Y, Yokawa S, Furuno T. Inhibition of degranulation in mast cells attached to a hydrogel through defective microtubule tracts. Exp. Cell. Res., 381, 248-255 (2019)

Pharmaceutical Engineering

Topics of research
  • Nucleic acid drug delivery with PLGA nanopartcile
  • Development of polymeric micelle and nanoparticle for treatment of biofilm infections
  • Solubility improvement technique for poorly water soluble derugs
  • Evaluation and improvement of physical properties of Moh's paste for cancer therapy
  • Ogawa N, Nagase H, Matsumoto T, Kaga M, Ishihara S, Endo T, Yasunaga T, Kawashima Y, Ueda H, Yamamoto H. Crystallographic evaluation of the conformation of quetiapine included in β-cyclodextrin. Int. J. Pharm., 587, 119625 (2020)
  • Suzuki T, Sasai A, Tsujimoto H, Yasunaga T, Ogawa N, Yamamoto H. Promoting effect of type 17 collagen production by chlorogenic acid using PLGA nanoparticles in the human epidermal keratinocyte cell. J. Drug Delivery Sci. Tech., 58, 101624 (2020)
  • Takahashi C, Hattori Y, Yagi S, Murai T, Takai C, Ogawa N, Tanemura M, Fuji M, Kawashima Y, Yamamoto H. Optimization of ionic liquid-incorporated PLGA nanoparticles for treatment of biofilm infections. Mater. Sci. Eng. C, Mater. Biol. Appl., 97, 78-83 (2019)
  • Taguchi M, Shigeyama M, Ito N, Ogawa N, Takahashi C, Murata M, Hanioka N, Yamamoto H, Teramachi H. Preparation and Evaluation of Modified Mohs Paste without Starch. Yakugaku Zasshi, 137, 477-484 (2017)
  • Nagane K, Kimura S, Ukai K, Takahashi C, Ogawa N, Yamamoto H. Application of spherical silicate to prepare solid dispersion dosage forms with aqueous polymers. Int. J. Pharm., 493, 55-62 (2015)

Medicinal Biochemistry

  • Ayami Morita, Ph.D.
  • Toshifumi Hara, Ph.D.
Topics of research
  • Molecular mechanisms of peritoneal dissemination of scirrhous gastric cancers
  • Metabolome analysis for discovering novel molecular targets to inhibit cancer metastasis
  • Development of fused research field of regenerative medicine and cancer stem cells
  • A new approach of cancer therapy via adipose tissue-derived mesenchymal stem cells
  • Takei Y, Hara T, Suzuki A, Mihara K, Yanagihara K. Long non-coding RNA HOTAIR promotes epithelial-mesenchymal transition and is a suitable target to inhibit peritoneal dissemination in human scirrhous gastric cancers. Pathobiology, 87, 277-290 (2020).
  • Yamamoto T, Gotoh M, Koide N, Funahashi Y, Shimizu S, Takei Y. Influence of human adipose stem cells on prostate cancer cell growth. Nagoya Journal of Medical Science, 82, 217-224 (2020).
  • Takei Y. siRNA-based medicine targeting human bcl-xL against cancers. Methods in Molecular Biology, 1974: 31-40 (2019).
  • Takei Y, Shen G, Morita-Kondo A, Hara T, Mihara K, Yanagihara K. MicroRNAs regulating epithelial-mesenchymal transition can be targeted to inhibit peritoneal dissemination in human scirrhous gastric cancers. Pathobiology, 85, 232-246 (2018).
  • Takei Y, Suzuki A, Mihara K, Yanagihara K. The microRNA miR-516a-3p regulates the Wnt pathway by targeting extracellular sulfatase 1 in human scirrhous gastric cancers: Anti-metastatic therapy via miRNA-based medicine. Medical Research Archives, 5, 1-19 (2017).


Topics of research
  • Rapid detection and diagnosis of pathogenic bacteria.
  • Mechanisms of antibacterial resistance and development of drugs effective on multidrug resistant bacteria.
  • Bacterial pathogens and characteristics of emerging and re-emerging infectious disease.
  • Identification of pathogens related to inflammatory bowel disease and clinical development of their treatment and prevention.
  • Tomida J, Akiyama-Miyoshi T, Tanaka K, Hayashi M, Kutsuna R, Fujiwara N, Kawamura Y. Fusobacterium watanabei sp. nov. as additional species within the genus Fusobacerium, isolated from human clinical specimens. Anaerobe, In Press, (2021).
  • Tomida J, Fujiwara N, Naka T, Morita Y, Sawabe, E; Tojo N, Kikuchi K., Kawamura, Y. Spodiobacter cordis gen. nov. sp. nov., a member of the family Flavobacteriaceae isolated from patients with infective endocarditis. Microbiol Immunol., 63, 111-118, (2019)
  • Kutsuna R, Miyoshi-Akiyama T, Mori K, Hayashi M, Tomida J, Morita Y, Tanaka K, Kawamura Y. Description of Paraclostridium bifermentans subsp. muricolitidis subsp. nov., emended description of Paraclostridium bifermentans (Sasi Jyothsna et al., 2016), and creation of Paraclostridium bifermentans subsp. bifermentans subsp. nov. Microbiol Immunol., 63, 1-10, (2019)
  • Kutsuna R, Tomida J, Morita Y, Kawamura Y. Paraclostridium bifermentans exacerbates pathosis in a mouse model of ulcerative colitis PLOS ONE, 13, e0197668, (2018)
  • Tomida J, Morita Y, Shibayama K, Kikuchi K, Sawa T, Akaike T, Kawamura Y. Diversity and microevolution of CRISPR loci in Helicobacter cinaedi PLOS ONE 12, e0186241, (2017)


  • Yoshiaki Ohi, Ph.D.
  • Daisuke Kodama, Ph.D.
Topics of research
  • Neuropharmacology of neuronal network in respiratory center, cough center and trigeminal spinal tract
  • Regulatory system of synaptic transmission
  • Analysis of respiratory regulation
  • Ohi, Y., Kodama, D., Haji, A.: Involvement of the cAMP-dependent pathway in dextromethorphan-induced inhibition of spontaneous glutamate transmission in the nucleus tractus solitarius neurons of guinea pigs. Pharmacology 103, 76-81, 2019.
  • Asaoka, R., Ohi, Y., Miyazawa, K., Goto, S., Haji, A.: Involvement of presynaptic TRPV1 channels in prostaglandin E2-induced facilitation of spontaneous synaptic transmission in the rat spinal trigeminal subnucleus caudalis. Brain Research 1715, 115-125, 2019.
  • Ohi, Y., Kodama, D., Haji, A.: Effects of progesterone on hypoxia-induced inhibition of excitatory synaptic transmission in the rat nucleus tractus solitarius. Journal of Pharmacological Sciences 140, 305-309, 2019.
  • Kodama, D., Hirai, T., Kondo, H., Hamamura, K., Togari, A.: Bidirectional communication between sensory neurons and osteoblasts in an in vitro coculture system. FEBS Letters 591, 527-539, 2017.
  • Ohi, Y., Kodama, D., Haji, A.: L-DOPA inhibits excitatory synaptic transmissions in the rat nucleus tractus solitarius through release of dopamine. Neuroscience 360, 18-27, 2017.

Pharmaceutical Health Sciences

Topics of research
  • Molecular mechanism of harmful metal toxicity (mainly, cadmium)
  • Clarification of new physiological function of metallothionein
  • Disease prevention through functional regulation of biological protection system using organometals
  • Lee JY, Tokumoto M, Satoh M. Cadmium toxicity mediated by the inhibition of SLC2A4 expression in human proximal tubule cells. FASEB J., 35, e21236 (2021).
  • Fujiwara Y, Lee JY, Banno H, Imai S, Tokumoto M, Hasegawa T, Seko Y, Nagase H, Satoh M. Cadmium induces iron deficiency anemia through the suppression of iron transport in the duodenum. Toxicol. Lett., 332, 130-139 (2020).
  • Tokumoto M, Lee JY, Satoh M. Transcription Factors and Downstream Genes in Cadmium Toxicity. Biol. Pharm. Bull., 42, 1083-1088 (2019).
  • Tokumoto M, Lee JY, Shimada ., Tohyama C, Satoh M. Glutathione has a more important role than metallothionein-I/II against inorganic mercury-induced acute renal toxicity. J. Toxicol. Sci., 43, 275-280 (2018).
  • Lee JY, Tokumoto M, Hwang GW, Lee MY, Satoh M. Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity. Sci. Rep., 7, 17287 (2017).


Topics of research
  • Studies on the pathogenesis of diabetic complications and the development of their treatments based on pathogenic mechanisms
  • Evaluation and development of self-monitoring of blood glucose (SMBG) devices and diabetes education
  • Evaluation and development of insulin injection device and diabetes education
  • Genetic diagnosis of hereditary liver disease (Hemochromatosis, Wilson disease)
  • Motegi M, Himeno T, Nakai-Shimoda H, Inoue R, Ozeki N, Hayashi Y, Sasajima S, Mohiuddin MS, Asano-Hayami E, Kato M, Asano S, Miura-Yura E, Morishita Y, Kondo M, Tsunekawa S, Kato Y, Kato K, Naruse K, Seino Y, Hayashi Y, Nakamura J, Kamiya H. Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice. Biochem Biophys Res Commun., 532, 47-53 (2020)
  • Takami A, Tatsumi Y, Sakai K, Toki Y, Ikuta K, Oohigashi Y, Takagi J, Kato K, Takami K. Juvenile Hemochromatosis: A Case Report and Review of the Literature. Pharmaceuticals, 13, E195 (2020)
  • Tatsumi Y, Kato A, Sango K, Himeno T, Kondo M, Kato Y, Kamiya H, Nakamura J, Kato K. Omega-3 Polyunsaturated Fatty Acids Exert Antioxidant Effects Through the Nrf2 Pathway in the Immortalized Mouse Schwann IMS32 Cells. J Diabetes Invest., 10, 602-612 (2019)
  • Kato A, Tatsumi Y, Yako H, Sango K, Himeno T, Kondo M, Kato Y, Kamiya H, Nakamura J, Kato K. Recurrent short-term hypoglycemia and glucose fluctuation induce apoptosis and oxidative stress via the ER stress response in immortalized adult mouse Schwann (IMS32) cells. Neuroscience Res., 147, 26-32 (2019).
  • Tatsumi Y, Kato A, Kato K, Hayashi H. The interactions between iron and copper in genetic iron overload syndromes and primary copper toxicoses in Japan. Hepatol Res., 48, 679-691 (2018).

Cellular Pharmacology

Topics of research
  • Transcriptional control of TRP channel expression
  • Epigenetical regulation of TRP channel gene
  • Modification of TRP channel function by clinical drugs
  • Yoneda M, Suzuki H, Hatano N, Nakano S, Muraki Y, Miyazawa K, Goto S & Muraki K. PIEZO1 and TRPV4, which are distinct mechano-sensors in the osteoblastic MC3T3-E1 cells, modify the cell-proliferation. Int. J. Mol. Sci. 20 (19), e4960 (2019)
  • Suzuki T#, Muraki Y##, Hatano N##, Suzuki H## & Muraki K#. PIEZO1 channel is a potential regulator of synovial sarcoma cell-viability. Int. J. Mol. Sci. 19 (5), e1452 (2018). #, ##: equal contributions
  • Muraki K, Ohnishi K, Takezawa A, Suzuki H, Hatano N, Muraki Y, Hamzah N, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS & Beech DJ. Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells. Sci. Rep. 7(1), 16988 (2017).
  • Muraki K, Sekine T, Ando Y, Suzuki H, Hatano N, Hirata T & Muraki Y. An environmental pollutant, 9,10-phenanthrenequinone, activates human TRPA1 via critical cysteines 621 and 665. Pharmacol. Res. & Persp. 5, e00342 (2017).
  • Suzuki H*, Sasaki E#, Nakagawa A#, Muraki Y, Hatano N & Muraki K*. Diclofenac, a non-steroidal anti-inflammatory drug, is an antagonist of human TRPM3 isoforms. Pharmacol. Res. & Persp. 4, e00232 (2016). *, #: equal contribution


Topics of research
  • Membrane transporters in pharmacokinetics and pharmacodynamics
  • Structure, function, and regulation of membrane transporters
  • Personalized and precision medicine
  • Kawasaki T, Shiozaki Y, Nomura N, Kawai K, Uwai Y, Nabekura T. Investigation of fluorescent substrates and substrate-dependent interactions of a drug transporter OATP2B1. Pharmaceutical Research, 37: 115 (2020)
  • Nabekura T, Kawasaki T, Kato Y, Kawai K, Fiorito S, Epifano F, Genovese S, Uwai Y. Citrus auraptene induces drug efflux transporter P-glycoprotein expression in human intestinal cells. Food and Function, 11: 5017-5023 (2020)
  • Uwai Y, Kondo R, Suzuki T, Kawasaki T, Nabekura T. Potent inhibition of biphasic tubular reabsorption of lithium by acetazolamide and foscarnet in rats. Physiological Research, 69: 645-651 (2020)
  • Nabekura T, Kawasaki T, Jimura M, Mizuno K, Uwai Y. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein. Biochemistry and Biophysics Reports, 21: 100727 (2020)
  • Uwai Y, Tsuduki M, Kawasaki T, Nabekura T. Effect of acetazolamide on lithium reabsorption and lithium-induced GSK3β phosphorylation in rat kidney. Die Pharmazie - An International Journal of Pharmaceutical Sciences, 74:611-613 (2019)

Clinical Pharmacy

Topics of research
  • Pharmaceutical research in the community pharmacies for improvement of drug therapy outcomes.
  • Effect of food thickener on disintegration of magnesium oxide tablets
  • Evaluation of the effects of diabetes-related hepatokine on tumor growth, angiogenesis, and platinum drug treatment.
  • Ando M, Nishioka H, Nakasako S, Kuramoto E, Ikemura M, Kamei H, Sono Y, Sugioka N, Fukushima S, Hashida T. Observational retrospective single-centre study in Japan to assess the clinical significance of serum daptomycin levels in creatinine phosphokinase elevation. Journal of Clinical Pharmacy and Therapeutics, 45, 290-297 (2020).
  • Uda H, Suga Y, Toriba E, Staub AY, Shimada T, Sai Y, Kawahara M, Matsushita R. Multiday corticosteroids in cancer chemotherapy delay the diagnosis of and antimicrobial administration for febrile neutropenia: a double-center retrospective study. Journal of Pharmaceutical Health Care and Sciences, 5, 3 (2019).
  • Ando M, Nakasako S, Ariyoshi K, Yamaguchi M, Sakizono K, Minowa K, Fukushima S, Sugioka N, Hashida T. Re-elevation of serum amlodipine level after lipid emulsion therapy in an overdose case. Journal of Clinical Pharmacy and Therapeutics, 44, 970-973 (2019).
  • Osada T, Watanabe N, Asano N, Adachi Y, Yamamura K. Adverse drug events affecting medication persistence with rivastigmine patch application. Patient Preference and Adherence, 12, 1247-1252 (2018).
  • Watanabe N, Hosokawa S, Osumi Y, Imanishi T, Koga R, Higashi T, Yamada T, Yamamura K. A case of successful concomitant administration of warfarin and uracil-tegafur/leucovorin achieved by self-measurement of INR. Journal of General and Family Medicine, 18, 82-85 (2017).

Pharmacy Practice and Sciences

Topics of research
  • Investigation of proper administration of medicines
  • Investigation of quality and stability assessment of medicines
  • Interaction between drugs and medical devices
  • Umemura M, Muramatsu S, Fukutani Y, Ikegami Y, Yoshida A, Yanagihara T, Wakiya Y. Interaction between Commercial Denture Adhesives and a Various Orally Disintegrating and Sublingual Prescription Drugs. Applied Therapeutics,12, 11-18 (2019).
  • Umemura M, Maegawa K, Arai D, Shigeno K, Wakiya Y. Influence of technique used to attach the infusion set to peristaltic finger smart-pumps on dispensing time: an experimental study. J. Pharm. Health. Care. Sci., 4, 8 (2018).
  • Maruyama M, Umemura M. Effect of octreotide acetate on nausea symptoms in terminal cancer in the absence of gastrointestinal obstructions. Jpn. J. Pharm. Palliat. Care. Soc., 10, 105-110 (2017).
  • Umemura M, Arai D, Maegawa K, Shigeno K, Wakiya Y. Factors Influencing the Accurate Administration of Peristaltic Finger Infusion Pumps Attached to Polyvinylchloride Infusion Sets Containing Tris(2-ethylhexyl) trimellitate. Yakugaku Zasshi, 136, 761-767 (2016).
  • Umemura M, Itoh A, Ando Y, Yamada K, Wakiya Y, Nabeshima T. Effects of outside air temperature on the preparation of antineoplastic drug solutions in biological safety cabinets. J. Oncol. Pharm. Pract., 21, 243-248 (2015).

Pharmaceutical Health Care and Sciences

Topics of research
  • Contribution for ensuring effectiveness and safety of medicines in collaboration with hospital and community pharmacies
  • Comparative Study on quality and stability of pharmaceutical products and health foods
  • Investigation on medical evidence of health foods
  • Urano K, Ishibashi M, Matsumoto T, Ohishi K, Muraki Y, Iwamoto T, Kunimasa J, Okuda M. Impact of physician-pharmacist collaborative protocol-based pharmacotherapy management for HIV outpatients: A retrospective cohort study. J Pharm Health Care Sci, 6, 9, doi: 10.1186/s40780-020-00165-9 (2020).
  • Tsukiyama I, Ejiri M, Yamamoto Y, Nakao H, Yoneda M, Matsuura K, Arakawa I, Saito H, Inoue T. A Cost-Effectiveness Analysis of Gemcitabine plus Cisplatin Versus Gemcitabine Alone for Treatment of Advanced Biliary Tract Cancer in Japan. J Gastrointest Cancer., 48, 326-332 (2017).
  • Yamamoto Y, Watanabe K, Matsushita H, Tsukiyama I, Matsuura K, Wakatsuki A. Multivariate analysis of risk factors for cisplatin-induced nephrotoxicity in gynecological cancer. J. Obstet. Gynaecol. Res., 43, 1880-1886 (2017).
  • Yoshida S, Suzuki A, Ohmori T, Niwa T, Okada H, Suzuki K, Kobayashi R, Doi T, Kitaichi K, Matsuura K, Murakami N, Ogura S, Itoh Y. A simplified chart for determining the initial loading dose of teicoplanin in critically ill patients. Pharmazie., 72, 53-57 (2017).
  • Yamamoto Y, Watanabe K, Tsukiyama I, Yabushita H, Matsuura K, Wakatsuki A. Hydration with 15 mEq Magnesium Is Effective at Reducing the Risk for Cisplatin-induced Nephrotoxicity in Patients Receiving Cisplatin (≥50 mg/m2) Combination Chemotherapy. Anticancer Res., 36, 1873-1877 (2016).

Education and Research Division of Pharmacy

Topics of research
  • Education of pharmaceutical science
  • Molecular mechanism underlying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and dementia
  • Mechanism of RNA transport
  • Kato Y., Yokogawa M., Nakagawa I., Onodera K., Okano H., Inoue H., Hattori M., Okada Y. *, Tsuiji H. *C9ORF72 dipeptide repeat proteins disrupt formation of GEM bodies and induce aberrant accumulation of survival of motor neuron protein bioRxiv (2021)
  • Inagaki H., Hosoda N., Tsuiji H., Hoshino S. Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation Journal of Biological Chemistry, 295(47), pp.15810 - 15825, (2020)
  • Okugawa E., Ogino H., Shigenobu T., Yamakage Y., Tsuiji H., Oishi H., Kohno T., Hattori M. Physiological significance of proteolytic processing of reelin revealed by cleavage-resistant reelin knock-in mice Scientific Reports, 10(1), 4471 (2020)
  • Yamakage Y., Kato M., Hongo A., Ogino H., Ishii K., Ishizuka T., Kamei T., Tsuiji H., Miyamoto T., Oishi H., Kohno T., Hattori M. A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum Molecular and Cellular Neuroscience, 100, 103401 (2019)
  • Nishino K., Watanabe S., Shijie J., Murata Y., Oiwa K., Komine O., Endo F., Tsuiji H., Abe M., Sakimura K., Mishra A., Yamanaka K. Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway Acta Neuropathologica Communications, 7(1), 118 (2019)


Topics of research
  • specific amino acid metabolism in pediatric cancer disorders
  • new biomarker in Kawasaki disease or juvenile rheumatic disease
  • specific vasoactive substance in tumor metastatic niche
  • Minoia F, Tibaldi J, Muratore V, Gallizzi R, Bracaglia C, Arduini A, Comak E, Vougiouka O, Trauzeddel R, Filocamo G, Micalizzi C, Kasapcopur O, Unsal E, Kitoh T, Tsitsamis E, Kostik M, Cron R, Pachlopnik J, Maritsi D, Jelusic M, Shenoi S, Ravelli A. A Multinational Study of Thrombotic Microangiopathy in Macrophage Activation Syndrome: A Dreadful Condition Which Is Likely Underrecognized ARTHRITIS & RHEUMATOLOGY, 72, 189-190 (2020).
  • Kitoh T, Imura H, Nozaki F, Futami T, Kusunok T, Fujii T. Clinical course of juvenile- onset hyperuricemia complicated by Down ' s syndrome: Close correlation with thyroid dysfunction and high obesity. International Journal of Rheumatic Diseases, 23(S1), 34 (2020).
  • Kitoh T, Ohara T, Muto T, Okumura A, Koizumi Y, Yamagishi Y, et al. PENTRAXIN 3 is the Best Biomarker of Kawasaki Disease: Predictor of IVIG Non-Responder and Coronary Artery Lesion and Sequellae. Eur. J. Pediatr., 178, 1799 (2019).
  • Morimoto A, Shioda Y, Imamura T, Kudo K, Kitoh T, Kawaguchi H, Goto H, Kosaka Y, Tsunematsu Y, Imashuku S. Intensification of induction therapy and prolongation of maintenance therapy did not improve the outcome of pediatric Langerhans cell histiocytosis with single-system multifocal bone lesions: results of the Japan Langerhans Cell Histiocytosis Study Group-02 Protocol Study. Int J Hematol., 108, 192-198 (2018).
  • Kitoh T, Kitagawa Y, Baba R, Kaneko A, Hayakawa T, Muto T, Okumura A, Murotani K, Kume N, Hamakubo T. Increased levels of plasma pentraxin 3 predict IVIG resistance and coronary artery lesion formation in patients with Kawasaki disease. Rheumatology, 56, Supplement 3 (2017).