Aichi Gakuin University, School of Pharmacy

Research Fields

Organic and Medicinal Chemistry

Staff
Topics of research
  • Synthesis, molecular structure and reactivity of novel hypervalent compounds having group 15 and 16 elements
  • Synthesis and property of novel heterocyclic compounds containing main group elements
  • Bio-organometallics: Synthesis and bioactivity of organometallic compounds
Publications
  • Koyanagi, A., Murata, Y., Matsumura, M., Yasuike, S. Synthesis of sulfenamides from benzoazole-2-thiones with primary and secondary amines using triphenylbismuth dichloride-mediated S-N bond formation reaction. Asian J. Org. Chem., 13, e202400138 (2024). Selected as a Front Cover Picture.
  • Kawakubo, M., Inoh, Y., Murata, Y., Matsumura, M., Furuno, T., Yasuike, S. Novel mono substituted pyridoimidazoisoquinoliniums via a silver-catalyzed intramolecular cyclization and their applications in cellular imaging. RSC Adv., 14, 9758-9762 (2024).
  • Matsumura, M., Nakamura, A., Yanagida, A., Murata, Y., Yasuike, S. Copper-catalyzed three-component reaction of pyrazol-3-ones (antipyrine), triarylbismuthines, and selenium: Synthesis of 4-selanylpyrazol-3-ones. Tetrahedron, 142, 133526 (2023).
  • Murata, Y., Nishi, Y., Matsumura, M., Yasuike, S. Palladium-catalyzed cross-coupling reaction of bis(cyclopentadienyl)diaryltitaniums with terminal alkynes. Reactions, 4, 657-666 (2023). Selected as Highlighted paper.
  • Kitamura Y, Matsumura M, Kato Y, Murata Y, Yasuike S. Cascade synthesis of 4-arylcoumarins: Pd-catalyzed arylations and cyclizations with (E)-ethyl 3-(2-hydroxyaryl)acrylates and triarylantimony difluorides. Eur. J. Org. Chem., 2020, 1652-1657 (2020). Selected as Very Important Paper (VIP).

Bioorganic Chemistry

Staff
Topics of research
  • Development of functional organic compounds for application in drug discovery and material science
Publications
  • Tanioka, M., Mori, M., Harada, M., Matsuya, Y., Kamino, S. Nonpolar selective emission (NPSE) of carbonyl-bridged rhodols. Chem. Commun., 60, 6407–6410 (2024).
  • Tanioka, M., Oyama, M., Nakajima, K., Mori, M., Harada, M., Matsuya, Y., Kamino, S. Coerulein B: a water-soluble and water-compatible near-infrared photoredox catalyst. Phys. Chem. Phys. Chem., 26, 4474–4479 (2024).
  • Harada, M., Kutsuna, M., Kitamura, T., Usui, Y., Ujiki, M., Nakamura, Y., Obata, T., Tanioka, M., Uchiyama, M., Sawada, D., Kamino, S. Nucleophile-triggered π-topological transformation: a new synthetic approach to near-infrared-emissive rhodamines. Chem. Eur. J., 29, e202301969 (2023).
  • Kamino, S., Uchiyama, M. Xanthene-based functional dyes: towards new molecules operating in the near-infrared region. Org. Biomol. Chem., 21, 2458–2471 (2023).
  • Tanioka, M., Kuromiya, A., Ueda, R., Obata, T., Muranaka, A., Uchiyama, M., Kamino, S. Bridged eosin Y: a visible and near-infrared photoredox catalyst. Chem. Commun., 58, 7825–7828 (2022).

Medicinal Resources

Staff
  • Kenichi Nakashima, Ph.D.
  • Tomoki Mizoguchi
Topics of research
  • Discovery of naturally occurring compounds with biological activities, such as nuclear receptor ligand activity.
  • Isolation, identification, and structural analysis of naturally occurring compounds with novel structures.
  • Development of natural compound-derived therapeutic agents for lifestyle-related and chronic inflammatory diseases.
Publications
  • Tomita, K., Nakashima, K., Yamaguchi, Y., Itoh, A., Inoue, M. Dual anti-inflammatory actions of a novel retinoid X receptor agonist derived from a natural compound in microglial cells. Biol. Pharm. Bull., 48, 440–449 (2025).
  • Tateiwa, R., Nakama, Y., Murase, A., Mizoguchi, T., Inoue, M., Nakashima, K. Identification of a novel retinoid X receptor agonist from Boenninghausenia albiflora var. japonica. Chem. Pharm. Bull., 73, 173–178 (2025).
  • Nakashima, K., Abe, N., Oyama, M., Murata, H., Inoue, M. Sulfur-containing spiroketals from Breynia disticha and evaluations of their anti-inflammatory effect. Beilstein J. Org. Chem., 19, 1604–1616 (2023).
  • Nakashima, K., Okamura, M., Matsumoto, I., Kameda, N., Tsuboi, T., Yamaguchi, E., Itoh, A., Inoue, M. Regulation of adipogenesis through retinoid X receptor and/or peroxisome proliferator-activated receptor by designed lignans based on natural products in 3T3-L1 cells. J. Nat. Med., 77, 315–326 (2023).
  • Nakashima, K., Yamaguchi, E., Noritake, C., Mitsugi, Y., Goto, M., Hirai, T., Abe, N., Sakai, E., Oyama, M., Itoh, A., Inoue, M. Discovery and SAR of natural-product-inspired RXR agonists with heterodimer selectivity to PPARδ-RXR. ACS Chem. Biol., 15, 1526–1534 (2020).

Analytical Chemistry and Biophysics

Staff
Topics of research
  • Molecular mechanism of cell function modulation mediated by adhesion molecules
  • Analysis of molecular mechanism of mast cell activation and its regulation
  • Intracellular transport and exocytosis of secretory granules
Publications
  • Horisaka, H., Yokawa, S., Suzuki, R., Emoto, R., Maeda, R., Furuno, T. Suppression of FcεRI-evoked degranulation in RBL-2H3 cells on gelatin methacryloyl hydrogel. Cell Biochem. Biophys., 83, 2481–2488 (2025).
  • Inouye, S., Hisada, S., Nakamura, M., Yokawa, S., Suzuki, T. Conversion of dehydrocoelenterazine to coelenterazine in mammalian cells: Identification using cultured cells stably expressing coelenterazine-utilizing luciferase. Biochem. Biophys. Res. Commun., 735, 150795 (2024).
  • Inoh, Y., Itoh, N., Yokawa, S., Suzuki, R., Furuno, T. Surface charge, but not size, of liposomes is involved in the suppression of rat basophilic leukemia (RBL-2H3) cell degranulation mediated by Akt phosphorylation. Cell Biol. Int., 48, 1463–1472 (2024).
  • Sugimoto, H., Fukuda, S., Yokawa, S., Hori, M., Ninomiya, H., Sato, T., Miyazawa, K., Kawai, T., Furuno, T., Inouye, S., Goto, S., Suzuki, T. Visualization of osteocalcin and bone morphogenetic protein 2 (BMP2) secretion from osteoblastic cells by bioluminescence imaging. Biochem. Biophys. Res. Commun., 635, 203–209 (2022).
  • Suzuki, R., Inoh, Y., Yokawa, S., Furuno, T., Hirashima, N. Receptor dynamics regulates actin polymerization state through phosphorylation of cofilin in mast cells. Biochem. Biophys. Res. Commun., 534, 714–719 (2021).

Pharmaceutical Engineering

Staff
Topics of research
  • Development of drug delivery system with biodegradable nanoparticles
  • Improvement of the solubility of poorly water-soluble drugs
  • Development of dry coating processes
  • Traceability study for pharmaceutical products
Publications
  • Yasunaga, T., Fukuoka, T., Yamaguchi, A., Ogawa, N., Yamamoto, H. Application of stealth nanobeacon for traceability assurance in pharmaceutical tablets via surface-enhanced Raman scattering during the tablet coating process. Int. J. Pharm., 666, 124810 (2024).
  • Oyama, S., Ogawa, N., Yasunaga, T., Yamamoto, H. Preparation of amorphous probucol with fluvastatin sodium salt and stability comparison studies of co-amorphous probucol with fluvastatin sodium salt and atorvastatin calcium trihydrate salt. Chem. Pharm. Bull., 72(12), 1073–1083 (2024).
  • Oyama, S., Ogawa, N., Kawai, K., Iwai, K., Yasunaga, T., Yamamoto, H. Improved dissolution properties of co-amorphous probucol with atorvastatin calcium trihydrate prepared by spray-drying. Chem. Pharm. Bull., 72(2), 190–199 (2024).
  • Yasunaga, T., Takahashi, Y., Kimura, Y., Minoda, K., Tochio, T., Ogawa, N., Yamamoto, H. Design of xylitol granules for direct tableting by using cellulose nanofiber.J. Soc. Powder Technol. Jpn., 60(1), 4–8 (2023).
  • Yasunaga, T., Yoshida, M., Shimosaka, A., Shirakawa, Y., Andoh, T., Ichikawa, H., Ogawa, N., Yamamoto, H. Mathematical modeling of coating time in dry particulate coating using mild vibration field with bead media described by DEM simulation. Adv. Powder Technol., 33(11), 103779 (2022).

Biochemistry

Staff
Topics of research
  • Malignant transformation of human cancer cells
  • Cell differentiation and osteoporosis
  • Glycans in species-species interactions
  • Methyltransferases in human cancer cells
Publications
  • Reduced form of Galectin-1 Suppresses Osteoclastic Differentiation of Human Peripheral Blood Mononuclear Cells and Murine RAW264 Cells In Vitro., Takeuchi T, Oyama M, Tamura M, Arata Y, Hatanaka T., Biomolecules. 2024;14(1):121.
  • Effect of Chitosan Degradation Products, Glucosamine and Chitosan Oligosaccharide, on Osteoclastic Differentiation., Takeuchi T, Oyama M, Hatanaka T., BioTech (Basel). 2024;13(1):6.
  • In vitro evaluation of the effect of galectins on Schistosoma mansoni motility., Takeuchi T, Nakamura R, Hamasaki M, Oyama M, Hamano S, Hatanaka T., BMC Res Notes. 2023;16(1):266.
  • Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers. Hara T, Tominaga Y, Ueda K, Mihara K, Yanagihara K, Takei Y., Biochem Biophys Rep. 2022;30:101255.
  • Elevated Expression of CELSR1 is Associated with Peritoneal Metastasis in Human Scirrhous Gastric Cancers. Hara T, Nomura Y, Hattori M, Mihara K, Yanagihara K, Takei Y., BPB Reports. 2021;4(4):103-111.

Microbiology

Staff
Topics of research
  • Rapid detection and diagnosis of pathogenic bacteria.
  • Bacterial pathogens and characteristics of emerging and re-emerging infectious disease.
  • Identification of pathogens related to inflammatory bowel disease and clinical development of their treatment and prevention.
  • Exploration of Biodegradable Plastic-Producing Bacteria / Plastic-Degrading Bacteria
Publications
  • Hasegawa, Y., Akita, T., Kuchibiro, T., Miyoshi-Akiyama, T., Tomida, J., Kutsuna, R., Mori, R., Okuno, M., Ogura, Y., Kawamura, Y. Streptococcus suis subsp. hashimotonensis subsp. nov.: Lancefield group A antigen–positive organisms isolated from human clinical specimens and wild boar oral cavity samples. Syst. Appl. Microbiol., 126538. (2024).
  • Tomida, J., Miyoshi-Akiyama, T., Kutsuna, R., Tsutsuki, H., Sawa, T., Cnockaert, M., Vandamme, P., Kawamura, Y. Proposal of Helicobacter higonensis sp. nov. isolated from a human clinical specimen, and emended description of Helicobacter valdiviensis Collado, 2014. Microbiol. Immunol., 68(6) 197-205 (2024).
  • Kutsuna, R., Miyoshi-Akiyama, T., Muramatsu, Y., Hamada, M., Tomida, J., Kikuchi, K., Kawamura, Y. Siderophore-producing Pantoea ferrattrahens sp. nov. isolated from a clinical specimen and Pantoea ferramans sp. nov. isolated from soil at the bottom of a pond. Microbiol. Immunol., 67, 480–489 (2023).
  • Kawamura, Y., Fujimoto, Y., Kutsuna, R., Tomida, J., Yamamoto, K., Miyoshi-Akiyama, T., Okuno, M., Ogura, Y., Matsuoka, M., Kawaguchi, T., Tsutsuki, H., Sawa, T. Helicobacter kumamotonensis sp. nov., isolated from human clinical specimens. Int. J. Syst. Evol. Microbiol., 73, 005732 (2023).
  • Kutsuna, R., Mashima, I., Miyoshi-Akiyama, T., Muramatsu, Y., Tomida, J., Kawamura, Y. Chryseobacterium lecithinasegens sp. nov., a siderophore-producing bacterium isolated from soil at the bottom of a pond. Int. J. Syst. Evol. Microbiol., 71(12) (2021).

Neuropharmacology

Staff
Topics of research
  • Regulatory system of synaptic transmission in the nucleus tractus solitarius
  • Pathology of neuropathic pain and its analgesics
  • Research on learning and memory using electrophysiological and behavioral pharmacological techniques
Publications
  • Suzuki, K., Ohi, Y., Sato, T., Tsuda, Y., Madokoro, Y., Mizuno, M., Adachi, K., Uchida, Y., Haji, A., Ojika, K., Matsukawa, N. Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice. Sci. Rep., 12(1), 19161 (2022).
  • Ohi, Y., Asai, Y., Kodama, D. Distinct effects of orexin A on spontaneous and evoked synaptic currents in the rat nucleus tractus solitarius. J. Pharmacol. Sci., 150(4), 244–250 (2022).
  • Kondo, H., Kondo, M., Hayashi, K., Kusafuka, S., Hamamura, K., Tanaka, K., Kodama, D., Hirai, T., Sato, T., Ariji, Y., Miyazawa, K., Ariji, E., Goto, S., Togari, A. Orthodontic tooth movement-activated sensory neurons contribute to enhancing osteoclast activity and tooth movement through sympathetic nervous signalling. Eur. J. Orthod., 44(4), 404–411 (2022).
  • Tamada, M., Ohi, Y., Kodama, D., Miyazawa, K., Goto, S., Haji, A. Modulation of excitatory synaptic transmissions by TRPV1 in the spinal trigeminal subnucleus caudalis neurons of neuropathic pain rats. Eur. J. Pharmacol., 913, 174625 (2021).

Public Health

Staff
Topics of research
  • Molecular mechanism of harmful metal toxicity (mainly, cadmium)
  • Clarification of new physiological function of metallothionein
  • Disease prevention through functional regulation of biological protection system using organometals
Publications
  • Lee, J.Y., Yoshida, M., Satoh, M., Watanabe, C. Neurobehavioral effects of the exposure to mercury vapor and methylmercury during postnatal period on mice. Toxicol. Res., 40, 111–124 (2024).
  • Tokumoto, M., Lee, J.Y., Fujiwara, Y., Satoh, M. Long-term exposure to cadmium causes hepatic iron deficiency through the suppression of iron-transport-related gene expression in the proximal duodenum. Toxics, 11(7), 641 (2023).
  • Mori, C., Lee, J.Y., Tokumoto, M., Satoh, M. Cadmium toxicity is regulated by peroxisome proliferator-activated receptor δ in human proximal tubular cells. Int. J. Mol. Sci., 23, 8652 (2022).
  • Lee, J.Y., Mori, C., Tokumoto, M., Satoh, M. Changes in DNA-binding activity of transcription factors in the kidney of mice exposed to cadmium. J. Toxicol. Sci., 46, 125–129 (2021).
  • Lee, J.Y., Tokumoto, M., Satoh, M. Cadmium toxicity mediated by the inhibition of SLC2A4 expression in human proximal tubule cells. FASEB J., 35, e21236 (2021).

Medicine

Staff
Topics of research
  • Studies on the pathogenesis of diabetic complications and the development of their treatments based on pathogenic mechanisms
  • Evaluation and development of self-monitoring of blood glucose (SMBG) devices and diabetes education
  • Evaluation and development of insulin injection device and diabetes education
  • Genetic diagnosis of hereditary liver disease (Hemochromatosis, Wilson disease)
Publications
  • Kato, A., Nihei, W., Yako, H., Tatsumi, Y., Himeno, T., Kondo, M., Kato, Y., Nakamura, J., Kamiya, H., Sango, K., Kato, K. Imeglimin improves hyperglycemia and hypoglycemia-induced cell death and mitochondrial dysfunction in immortalized adult mouse Schwann IMS32 cells. J. Diabetes Investig., in press (2025).
  • Tatsumi, Y., Yano, M., Wakusawa, S., Miyajima, H., Ishikawa, T., Imashuku, S., Takano, A., Nihei, W., Kato, A., Kato, K., Hayashi, H., Yoshioka, K., Hayashi, K. A revised classification of primary iron overload syndromes. J. Clin. Transl. Hepatol., 12, 346–356 (2024).
  • Nihei, W., Kato, A., Himeno, T., Kondo, M., Nakamura, J., Kamiya, H., Sango, K., Kato, K. Hyperglycaemia aggravates oxidised low-density lipoprotein-induced Schwann cell death via hyperactivation of Toll-like receptor 4. Neurol. Int., 16, 370–379 (2024).
  • Tatsumi, Y., Kato, A., Niimi, N., Yako, H., Himeno, T., Kondo, M., Tsunekawa, S., Kato, Y., Kamiya, H., Nakamura, J., Higai, K., Sango, K., Kato, K. Docosahexaenoic acid suppresses oxidative stress-induced autophagy and cell death via the AMPK-dependent signaling pathway in immortalized Fischer rat Schwann cells. Int. J. Mol. Sci., 23, 4405 (2022).

Cellular Pharmacology

Staff
  • Katsuhiko Muraki, Ph.D.
  • Noriyuki Hatano, Ph.D.(also affiliated with Laboratory of Education and Research Division of Pharmacy)
  • Hiroka Suzuki, Ph.D.
  • Ayami Morita, Ph.D.
Topics of research
  • under construction (please check our publications in Pubmed)
Publications
  • M Matsubara, Y Muraki, H Suzuki, N Hatano & K Muraki. Critical Amino Acid Residues Regulating TRPA1 Zn2+ Response: A Comparative Study Across Species. J. Biol. Chem., 300(6):107302 (2024).

Pharmaceutics

Staff
Topics of research
  • Membrane transporters in pharmacokinetics and pharmacodynamics
  • Structure, function, and regulation of membrane transporters
  • Regulatory mechanisms of drug-metabolizing enzymes
  • Personalized and precision medicine
Publications
  • Uwai, Y., Nabekura, T. A safety signal for congenital strabismus associated with valproic acid: A pharmacovigilance analysis utilizing the FDA Adverse Event Reporting System database. Congenit. Anom., 64(5), 207–214 (2024).
  • Uwai, Y., Nabekura, T. Relationship between clozapine and non-hematological malignant tumors: A pharmacovigilance analysis using the FDA Adverse Event Reporting System database. Drugs Real World Outcomes, 11(2), 185–193 (2024).
  • Uwai, Y., Nabekura, T. Data mining for risks of clozapine side effects, including neutropenia, associated with lithium carbonate administration: Analysis using the Japanese Adverse Drug Event Report database. Drugs Real World Outcomes, 10(3), 481–489 (2023).
  • Uwai, Y., Nabekura, T. Risk of appendicitis associated with the use of clozapine: A pharmacovigilance study. Asian J. Psychiatry, 77, 103264 (2022).
  • Uwai, Y., Nabekura, T. Analysis of adverse drug events in patients with bipolar disorders using the Japanese Adverse Drug Event Report database. Pharmazie, 77(7), 255–261 (2022).

Clinical Pharmacy and Sciences

Staff
Topics of research
  • Pharmaceutical research in the hospital/community pharmacies for improvement of drug therapy outcomes.
  • Development of a rapid method for measuring blood drug concentrations by Raman spectroscopy for clinical application.
Publications
  • Watanabe, N., Ebisujima, M., Ichihara, T., Ando, M., Kawahara, M. Survey of dysphagia and related medications in nursing home residents using the Eating Assessment Tool (EAT-10) applied by community pharmacists: A single-center retrospective study. J. Pharm. Health Care Sci., 11, 38 (2025).
  • Ando, M., Watanabe, N., Seike, R., Gocho, S., Maeda, S., Inagaki, M., Kawahara, M. Quantification of gimeracil, tegafur, and 5-FU in human plasma via LC-MS/MS with a simplified pretreatment using flow-through extraction. J. Chromatogr. B, 1251, 124424 (2025).
  • Watanabe, N., Itano, A., Ando, M., Kawahara, M. Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study. J. Rural Med., 19, 192–195 (2024).
  • Kawahara, M., Moriyama, M., Fukatsu, M., Ando, M., Watanabe, N. Xanthan gum-based food thickeners reduce disintegration time of medical and OTC loxoprofen sodium tablets. Yakugaku Zasshi, 144, 231–237 (2024).
  • Ando, M., Suzuki, K., Kitamoto, R., Nakayama, A., Watanabe, N., Kawahara, M. Differences in serum selenoprotein P profile between C57BL/6 and BALB/c mice fed high-fat diet. J. Trace Elem. Med. Biol., 81, 127340 (2024).

Pharmacy Practice and Sciences

Staff
Topics of research
  • Research on the cost-saving effects and the impact on drug waste reduction
  • Research on disaster epidemiology, public health, and real-world data
  • Research on neurochemistry, neuropharmacology, and medical pharmacy
Publications
  • Ozeki, K., Ojima, T. Factors contributing to pharmacies with good disaster preparedness and the activities of their prefectural pharmaceutical association: Pharmacies' resilience and associations. Disaster Med. Public Health Prep., 18, e22 (2024).
  • Ozeki, K., Hada, K., Wakiya, Y. Factors influencing the degree of gastric atrophy in Helicobacter pylori eradication patients with drinking habits. Microorganisms, 12(7), 1398 (2024).
  • Tanaka, R., Liao, J., Hada, K., Mori, D., Nagai, T., Matsuzaki, T., Nabeshima, T., Kaibuchi, K., Ozaki, N., Mizoguchi, H., Yamada, K. Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene. Pharmacol. Res., 187, 106589 (2023).
  • Nakamura, N., Yoneda, K., Higo, T., Kusumoto, M. Monitoring of serum magnesium levels during long-term use of proton pump inhibitors in elderly Japanese patients: Is it really necessary or not? J. Pharm. Health Care Sci., 8(1), 35 (2022).
  • Hada, K., Wulaer, B., Nagai, T., Itoh, N., Sawahata, M., Sobue, A., Mizoguchi, H., Mori, D., Kushima, I., Nabeshima, T., Ozaki, N., Yamada, K. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: Association with morphological abnormalities in striatal neurons. Mol. Brain, 14(1), 21 (2021).

Pharmaceutical Health Care and Sciences

Staff
Topics of research
  • Contribution for ensuring effectiveness and safety of medicines in collaboration with hospital and community pharmacies
  • Comparative Study on quality and stability of pharmaceutical products and health foods
  • Research on HIV/AIDS
  • Investigation into Drug-Induced Cystitis
Publications
  • Yamamoto, Y., Tanaka, S., Matsuura, K., Yamamoto, S., Urano, K., Okita, J., Kato, E., Odagiri, T., Deguchi, Y. Effectiveness of opioid switching for dyspnea and its predictors in cancer patients: a single-center retrospective observational study. Jpn. J. Clin. Oncol., 54(7), hyae008 (2024).
  • Yamamoto, S., Fujii, H., Murayama, K., Iihara, H., Watanabe, D., Yamada, Y., Kobayashi, R., Kiyama, S., Makiyama, A., Urano, K., Matsuhashi, N., Suzuki, A., Matsuura, K. Efficacy and safety of oxaliplatin-based regimens as first-line chemotherapy in elderly patients with metastatic colorectal cancer. Anticancer Res., 43, 16710 (2023).
  • Yamamoto, Y., Yamamoto, S., Tsuge, T., Urano, K., Matsuura, K. Analysis of nausea and vomiting frequency following opioid dose escalation and its risk factors: a single-center retrospective observational study. J. Palliat. Med., 27, 0314 (2023).
  • Kato, T., Yasuda, Y., Okamoto, H., Saito, Y., Nakano, Y., Matsuura, K., Oonishi, M., Amano, T. Total body fluid is the factor that affects the pharmacokinetics of tolvaptan, and its efficacy, in acute worsening heart failure patients. Pharmacol. Res. Perspect., 11, 1088 (2023).
  • Urano, K., Ishibashi, M., Matsumoto, T., Ohishi, K., Muraki, Y., Iwamoto, T., Kunimasa, J., Okuda, M. Impact of physician-pharmacist collaborative protocol-based pharmacotherapy management for HIV outpatients: a retrospective cohort study. J. Pharm. Health Care Sci., 6, 9 (2020).

Education and Research Division of Pharmacy

Staff
Topics of research
  • Education of pharmaceutical science
  • Transcriptional regulation of membrane proteins, including ion channels and receptors
  • Alterations in the expression of membrane proteins, such as ion channels and receptors, and their implications in disease
Publications
  • Matsubara, M., Muraki, Y., Suzuki, H., Hatano, N., Muraki, K. Critical amino acid residues regulating TRPA1 Zn²⁺ response: A comparative study across species. J. Biol. Chem., 300, 107302 (2024).
  • Matsubara, M., Muraki, Y., Hatano, N., Suzuki, H., Muraki, K. Potent activation of human but not mouse TRPA1 by JT010. Int. J. Mol. Sci., 23, 14297 (2022).
  • Luostarinen, S., Hämäläinen, M., Hatano, N., Muraki, K., Moilanen, E. The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells. Pulm. Pharmacol. Ther., 70, 102059 (2021).
  • Hatano, N., Matsubara, M., Suzuki, H., Muraki, Y., Muraki, K. HIF-1α dependent upregulation of ZIP8, ZIP14, and TRPA1 modify intracellular Zn²⁺ accumulation in inflammatory synoviocytes. Int. J. Mol. Sci., 22, 6349 (2021).

Hygienic Chemistry

Staff
Topics of research
  • Relationship between staphylococcal toxins and allergic diseases
  • Development of nucleic acid aptamers
  • Development of Drugs targeting Stress-Responsive Transcription Factors
Publications
  • Kawano, S., Noda, C., Itoh, S., Urabe, A., Fujii, C., Ogawa, I., Suzuki, R., Hida, S. Staphylococcal superantigen-like protein 3 triggers murine mast cell adhesion by binding to CD43 and augments mast cell activation. Genes Cells, 29(5), 397–416 (2024).
  • Morikawa, A., Togawa, K., Mukainaka, R., Kitano, T.T., Itoh, S., Taki, S., Hida, S. Establishment of a Reporter System to Monitor FcRγ-Dependent Activation of NFAT. BPB Rep., 4, 110–115 (2024).
  • Tokugawa, M., Inoue, Y., Aoki, H., Miyajima, C., Ishiuchi, K., Tsurumi, K., Kujirai, C., Morishita, D., Matsuno, M., Mizukami, H., Ri, M., Iida, S., Makino, T., Aoyama, M., Hayashi, H. Involvement of cardiac glycosides targeting Na⁺/K⁺-ATPase in their inhibitory effects on c-Myc expression via its transcription, translation and proteasomal degradation. J. Biochem., 175, 253–263 (2024).
  • Kitano, T.T., Togawa, K., Takemori, J., Motoki, Y., Kishida, K., Itoh, S., Takamoto, M., Taki, S., Hida, S. Interleukin-3-dependent potentiation of IgE responsiveness in mouse basophils. Genes Cells, 28, 226–236 (2023).
  • Ogata, A., Hayashi, K., Kitano, T.T., Onozaki, K., Itoh, S., Hida, S. Staphylococcal γ-hemolysins induce IL-4 production in murine basophils. Biochem. Biophys. Res. Commun., 632, 107–112 (2022).