<おもな招待講演-Invited Presentations>

K Muraki. Critical Inhibition of Human TRPM3 by GPCR-Induced G-Protein Signalling: Strategies for Reversing Channel Suppression. CFS/ME International 2025: 4^th RID - Research Innovation and Discovery Conference (Keynote speaker, 12-13, Nov., 2025, Gold Coast, Australia)

K Muraki. Development of novel anti-anxiety drugs based on TRP channel studies. HU and AGU Collaboratory Symposium (Invited speaker, 7, Feb., 2025, Nagoya, Japan)

K Muraki. Approach of critical amino acid identification of TRP channels: Integration of computer science and experimental benchwork. CFS/ME International 2023: RID - Research Innovation and Discovery Conference (Keynote speaker, 9-10, Nov., 2023, Kings Cliff, Australia)

K Muraki. Comparison of TRPA1 and PIEZO1 channel functions among species. Ion Channel Modulation Symposium (ICMS), (Invited speaker, 22nd/23rd June, 2022, Clare College Cambridge, UK)

K Muraki. うつ病・不安症に対する扁桃体の関与とその神経基盤-TRPC1/4/5サブファミリーの生理機能と精神疾患への関与.　第14回日本不安症学会学術大会　ランチョンセミナー２（招待講演、2022年5月21日、東京）

K Muraki. PIEZO Channels as a sensor for mechanical stress. CFS/ME International 2021: RID - Research Innovation and Discovery Conference (Keynote speaker, 16-17, Nov., 2021, Gold Coast, Australia)

<おもな発表論文-Main Publications>

2026

Katsuhiko Muraki, Ayami Morita, Hiroka Suzuki, Yukiko Muraki, Functional conservation and species-specific tuning of PIEZO1 mechanotransduction in birds and humans. Preprint in Research Square, https://doi.org/10.21203/rs.3.rs-8855948/v1

Etianne Martini Sasso, Teagan S Er, Natalie Eaton-Fitch, Livia Hool, Katsuhiko Muraki and Sonya Marshall-Gradisnik. Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Front. Med., 08 January 2026 Sec. Translational Medicine Volume 12 - 2025 https://doi.org/10.3389/fmed.2025.1703924

2025

村木克彦 & 松原匡希. TRPA1 チャネルの機能進化. 愛知学院大学薬学会雑誌 第17巻　1-19 (2025)

Natalie Eaton-Fitch, Katsuhiko Muraki, Etianne Martini Sasso, Chandi Magawa, Sonya Marshall-Gradisnik. Analysis of Transient Receptor Potential Ion Channels in ME/CFS. Methods Mol Biol. 2025:2920:83-99. doi: 10.1007/978-1-0716-4498-0_6.

Etianne Martini Sasso, Natalie Eaton-Fitch, Peter Kenneth Smith, Katsuhiko Muraki, Sonya Marshall-Gradisnik. Low-Dose Naltrexone restored TRPM3 ion channel function in Natural Killer cells from long COVID patients. Front. Mol. Biosci 10.3389/fmolb.2025.1582967 (2025).

Mäki-Opas, I., Luostarinen, S., Hämäläinen, M., Muraki, K, Eeva Moilanen. The Contact Allergen Methylisothiazolinone (MIT) Is a Potent Activator of the TRPA1 Ion Channel. Pharmacol. Res. & Persp. 13, e70053 (2025). https://doi.org/10.1002/prp2.70053

2024

M Matsubara, Y Muraki, H Suzuki, N Hatano & K Muraki. Critical Amino Acid Residues Regulating TRPA1 Zn²⁺ Response: A Comparative Study Across Species. J. Biol. Chem., 300(6):107302 (2024). https://doi.org/10.1016/j.jbc.2024.107302

S Marshall-Gradisnik, E M Sasso, N Eaton-Fitch, P Smith, J N Baraniuk, K Muraki. Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants.　Plos One, 19(6): e0305704. doi: 10.1371/journal.pone.0305704. eCollection 2024.

A.V. Zholos, I.A. Greenwood, R.J. Lang, C.D. Benham, P.I. Aaronson, C.J. Garland, A.H. Weston, S.A. Prestwich, D.V. Gordienko, O.V. Povstyan, H. Zhang, L.H. Clapp, V. Pucovsky, M. Tare, C.J. Fenech, T. Unno, K. Muraki, J. Shi, A.D. Hughes, T.K. Halstead and D.J. Beech. Thomas (Tom) B. Bolton - a major force in smooth muscle research. J. Physiol., 2024 Aug;602(15): 3601-3604. doi: 10.1113/JP287062.

E M Sasso, K Muraki, N Eaton-Fitch, P K Smith, A Jeremijenko, P Griffin, S Marshall-Gradisnik. Investigation into the restoration of TRPM3 ion channel activity in post COVID-19 condition: a potential pharmacotherapeutic target. Front. Immunol. 15: 1264702. doi: 10.3389/fimmu.2024.1264702. eCollection 2024.

2022

M Matsubara, Y Muraki, N Hatano, H Suzuki & K Muraki. Potent Activation of Human but Not Mouse TRPA1 by JT010. Int. J. Mol. Sci. 23(22), 1429, (2022).

E M Sasso, K Muraki, N Eaton-Fitch P Smith, O L Lesslar, G Deed, S Marshall-Gradisnik.　Transient receptor potential melastatin 3 dysfunction in post COVID-19 condition and myalgic encephalomyelitis/chronic fatigue syndrome patients.　Mol. Med.;28(1): 98 (2022).

N Eaton-Fitch, S D Preez, H Cabanas, K Muraki, D Staines, S Marshall-Gradisnik. Impaired TRPM3-dependent calcium influx and restoration using Naltrexone in natural killer cells of myalgic encephalomyelitis/chronic fatigue syndrome patients. J. Trans. Med. 20, 94 (2022).