愛知学院大学 薬学部 薬剤学講座

2021年

• Kawasaki T, Kondo M, Hiramatsu R, Nabekura T. (–)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters . ACS Omega. 6: 4347-4354. (2021)
• Uwai Y, Nabekura T. Effect of Experimental Fanconi Syndrome on Tubular Reabsorption of Lithium in Rats. Pharmacology. Online ahead of print. (2021)

2020年

• Uwai Y, Tsuduki M, Kawasaki T, Nabekura T. Potent Inhibition of Biphasic Tubular Reabsorption of Lithium by Acetazolamide and Foscarnet in Rats. Physiol Res. 69: 645-651. (2020)
• Nabekura T, Kawasaki T, Kato Y, Kawai K, Fiorito S, Epifano F, Genovese S, Uwai Y. Citrus auraptene induces drug efflux transporter P-glycoprotein expression in human intestinal cells. Food & Function. 11: 5017-5023. (2020)
• Kawasaki T, Shiozaki Y, Nomura N, Kawai K, Uwai Y, Nabekura T. Investigation of Fluorescent Substrates and Substrate-Dependent Interactions of a Drug Transporter Organic Anion Transporting Polypeptide 2B1 (OATP2B1). Pharm Res. 37: 115. (2020)
• Nabekura T, Kawasaki T, Jimura M, Mizuno K, Uwai Y. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein. Biochem Biophys Rep. 21: 100727. (2020)

2019年

• Uwai Y, Tsuduki M, Kawasaki T, Nabekura T. Effect of acetazolamide on lithium reabsorption and lithium-induced GSK3β phosphorylation in rat kidney. Pharmazie. 74: 611-613. (2019)

2018年

• Uwai Y, Suzuki T, Kondo R, Kawasaki T, Nabekura T. Effect of renal ischemia on urinary excretion of lithium in rats. Biopharm Drug Dispos. 39: 448-451. (2018)
• Uwai Y. Enantioselective Drug Recognition by Drug Transporters. Molecules. 23: E3062. (2018)
• Kawasaki T, Matsumoto T, Iwai Y, Kawakami M, Juge N, Omote H, Nabekura T, Moriyama Y. Purification and reconstitution of polyspecific H+/organic cation antiporter human MATE1. Biochim Biophys Acta Biomembr. 1860: 2456-2464. (2018)
• Uwai Y, Kawasaki T, Nabekura T. Nonlinear disposition of lithium in rats and saturation of its tubular reabsorption by the sodium-phosphate cotransporter as a cause. Biopharm Drug Dispos. 39: 83-87. (2018)
• Nabekura T, Kawasaki T, Furuta M, Kaneko T, Uwai Y. Effects of natural polyphenols on the expression of drug efflux transporter P-glycoprotein in human intestinal cells. ACS Omega. 3: 1621-1626. (2018)

2017年

• Uwai Y, Matsumoto M, Kawasaki T, Nabekura T. Enantioselective Effect of Flurbiprofen on Lithium Disposition in Rats. Pharmacology 99: 236-239. (2017)
• Kawasaki T, Takeichi Y, Tomita M, Uwai Y, Epifano F, Fiorito S, Taddeo VA, Genovese S, Nabekura T. Effects of phenylpropanoids on human organic anion transporters hOAT1 and hOAT3. Biochem Biophys Res Commun. 489: 375-380. (2017)
• Uwai Y, Kawasaki T, Nabekura T. D-Malate decreases renal content of alpha-ketoglutarate, a driving force of organic anion transporters OAT1 and OAT3, resulting in inhibited tubular secretion of phenolsulfonphthalein, in rats. Biopharm Drug Dispos. 38: 479-485. (2017)

2016年

• Uwai Y, Kawasaki T, Nabekura T. Foscarnet, an inhibitor of the sodium-phosphate cotransporter NaPi-IIa, inhibits phosphorylation of glycogen synthase kinase-3beta by lithium in the rat kidney cortex. Drug Metab Pharmacokinet. 31: 256-259. (2016)

2015年

• Nabekura T, Hiroi T, Kawasaki T, Uwai Y. Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein. Biomed Pharmacother. 70: 140-145. (2015)
• Uwai Y, Kawasaki T, Nabekura T. Minor contribution of biliary excretion in lithium elimination in rats. Drug Metab Pers Ther. 30: 65-67. (2015)
• Nabekura T, Kawasaki T, Kamiya Y, Uwai, Y. Effects of antiviral drugs on organic anion transport in human placental BeWo cells. Antimicrob Agents Chemother. 59: 7666-7670. (2015)
• Uwai Y, Tsuge M, Tokai Y, Kawasaki T, Nabekura T. Lithium interferes with the urinary excretion of phenolsulfonphthalein in rats: involvement of a reduced content of alpha-ketoglutarate, the driving force for organic anion transporters OAT1 and OAT3, in the kidney cortex. Pharmacology 96: 278-283. (2015)

2014年

• Uwai Y, Arima R, Takatsu C, Furuta R, Kawasaki T, Nabekura T. Sodium-phosphate cotransporter mediates reabsorption of lithium in rat kidney. Pharmacol Res. 87: 94-98. (2014)
• Uwai Y, Nakashima Y, Honjo E, Kawasaki T, Nabekura T. Diuresis by intravenous administration of xanthurenic acid in rats, and inhibition by probenecid. Biomed Res. 35: 223-6. (2014)
• Honjo H, Uwai Y, Nabekura T. Effect of selective cyclooxygenase-2 inhibitor lumiracoxib on phenolsulfonphthalein disposition in rats. Drug Metabol Drug Interact. Drug Metabol Drug Interact. 29: 203-6. (2014)
• Kawasaki T, Ito H, Omote H. Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1. Biol Pharm Bull. 37: 292-297. (2014)

2013年

• Uwai Y, Kawasaki T, Nabekura T. Caffeic acid inhibits organic anion transporters OAT1 and OAT3 in rat kidney. Drug Metabol Drug Interact. 28: 247-250. (2013)
• Uwai Y, Honjo E. Transport of xanthurenic acid by rat/human organic anion transporters OAT1 and OAT3. Biosci Biotechnol Biochem. 77: 1517-1521. (2013)
• Uwai Y, Hara H, Iwamoto K. Transport of Kynurenic Acid by Rat Organic Anion Transporters rOAT1 and rOAT3: Species Difference between Human and Rat in OAT1. Int J Tryptophan Res. 6: 1-6. (2013)
• Miyaji T, Kawasaki T, Togawa N, Omote H, Moriyama Y. Type 1 sodium-dependent phosphate transporter acts as a membrane potential-driven urate exporter. Curr Mol Pharmacol. 6: 88-94. (2013)

2012年

• Uwai Y, Honjo H, Iwamoto K. Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3. Pharmacol Res. 65: 254-260. (2012)

2011年

• Honjo H, Uwai Y, Aoki Y, Iwamoto K. Stereoselective inhibitory effect of flurbiprofen, ibuprofen and naproxen on human organic anion transporters hOAT1 and hOAT3. Biopharm Drug Dispos. 32: 518-524. (2011)
• Uwai Y, Ozeki Y, Isaka T, Honjo H, Iwamoto K. Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction. Drug Metab Pharmacokinet. 26: 486-493. (2011)
• [邦文] Uwai Y, Suzuki R, Iwamoto K. [Effect of nonsteroidal anti-inflammatory drugs on pharmacokinetics of methotrexate: a meta-analysis]. Yakugaku Zasshi. 131: 853-861. (2011)
• Honjo H, Uwai Y, Iwamoto K. Inhibitory effect of selective cyclooxygenase-2 inhibitor etoricoxib on human organic anion transporter 3 (hOAT3). Drug Metab Lett. 5: 140-137. (2011)

2010年

• Nabekura T, Yamaki T, Hiroi T, Ueno K, Kitagawa S. Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals. Pharmacol Res. 61: 259-263. (2010)
• Nabekura T. Overcoming multidrug resistance in human cancer cells by natural compounds. Toxins (Basel). 2: 1207-1224. (2010)
• Uwai Y, Honjo H, Iwamoto K. Inhibitory effect of selective cyclooxygenase-2 inhibitor lumiracoxib on human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet. 25: 450-455. (2010)
• Uwai Y, Iwamoto K. Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 25: 163-169. (2010)