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略歴
2002年8月 (韓国)高麗大学校 生命科学部 卒業
2010年3月 東北大学 大学院薬学研究科 博士課程修了
2010年4月 東北大学 大学院薬学研究科 博士研究員
2012年1月 愛知学院大学薬学部 助教
2014年4月 愛知学院大学薬学部 講師
2019年4月 愛知学院大学薬学部 准教授

学位 
博士(薬学)(東北大学、2010年)

専門分野
分子毒性学

研究テーマ
カドミウムの毒性発現に関わる標的分子の解明

教育担当科目
食品衛生・栄養学、環境衛生学、公衆衛生学、総合演習 I/II、総合演習 III/IV、基礎薬学実習 IV、生体予防薬学特論 II、外書読書 I/II、卒業研究

所属学会
日本薬学会、日本毒性学会、日本衛生学会、米国毒性学会

社会活動
  • 日本薬学会 環境・衛生部会 フォーラム委員会:国際交流小委員会 委員(2013年4月〜)
  • Journal of Toxicological Sciences, Editorial Board(2014年1月〜)
  • 日本毒性学会 評議員(2014年7月〜)
  • 第43回日本毒性学会学術年会 事務局長(2016年)
  • 日本薬学会 環境・衛生部会 必携・衛生試験法編集委員会 委員(2016年4月〜)
  • 日本薬学会 トピックス小委員会 委員(2017年4月〜2019年3月)
  • 日本毒性学会 生体金属部会 幹事(2018年7月〜)

学内活動
  • 薬学部 国際交流委員会 委員(2013年4月〜)
  • 薬学部 機器設備検討委員会 委員(2014年4月〜)
  • 薬学部 動物実験委員会 委員(2015年4月〜)
  • 薬学部 動物実験関連施設等運営委員会 委員(2015年4月〜)

表彰等

競争的資金
文部科学省・科学研究費助成事業 LINK
  • 平成28–30年度 文部科学省 科研費 基盤研究(C)(一般)(代表):カドミウム腎毒性発現における新規のカドミウム毒性決定因子BIRC3の役割の解明
  • 平成30–令和2年度 文部科学省 科研費 基盤研究(B)(一般)(分担):カドミウム毒性に対する感受性決定因子の同定
  • 平成30–令和2年度 文部科学省 科研費 基盤研究(C)(一般)(分担):成長期における水銀蒸気/メチル水銀複合曝露が神経行動機能に及ぼす影響と修飾因子
  • 令和3–5年度 文部科学省 科研費 基盤研究(C)(一般)(代表): 新規カドミウム毒性修飾因子の同定とその調節機構

財団
  • 平成27年度 公益財団法人 大幸財団 海外学術交流研究助成(代表):The 7th International Congress of Asian Society of Toxicology (ASIATOX2015) (Jeju, Korea) に招聘
  • 平成28年度(第26回)公益財団法人 大幸財団 自然科学系学術研究助成(代表):有害重金属カドミウムによる慢性腎障害に有用な生体予防因子の同定
  • 平成30年度 公益財団法人 大幸財団 海外学術交流研究助成(代表):The 8th International Congress of Asian Society of Toxicology (ASIATOX2018) (Pattaya, Thailand) に招聘
  • 2020年度 公益財団法人 武田科学振興財団 研究助成(代表):アポトーシス抑制因子BIRC5を介したがん治療における有害金属の抑制作用

その他

  • 平成25年度 愛知学院大学 医療生命薬学研究助成(分担):神経細胞のTRPA1活性に与えるオーラノフィンと有害金属の複合影響
  • 平成26年度 愛知学院大学 医療生命薬学研究助成(代表):中枢神経障害発症における各種水銀化合物の複合影響の解明(メタボロミクス法を用いたメチル水銀並びに水銀蒸気の複合曝露による脳内因子プロファイル解析)
  • 平成27年度 愛知学院大学 医療生命薬学研究助成(代表):各種水銀化合物の複合曝露による中枢神経障害発症におけるメタロチオネイン-IIIの関与


研究業績
原 著 論 文
  1. Lee J.Y., Yoshida M., Satoh M., Watanabe C. Neurobehavioral effects of the exposure to mercury vapor and methylmercury during postnatal period on mice. Toxicol. Res., 40, 111–124, 2024. https://doi.org/10.1007/s43188-023-00210-3
  2. Tokumoto M., Lee J.Y., Fujiwara Y., Satoh M. Long-term exposure to cadmium causes hepatic iron deficiency through the suppression of iron-transport-related gene expression in the proximal duodenum. Toxics, 11(7), 641, 2023. https://doi.org/10.3390/toxics11070641
  3. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Effect of cadmium on expression of BIRC family genes in HeLa cells. Fundam. Toxicol. Sci., 10, 133-136, 2023. https://doi.org/10.2131/fts.10.133
  4. Toyama T, Xu S, Kanemitsu Y, Hasegawa T, Noguchi T, Lee J.Y., Matsuzawa A, Naganuma A, Hwang G.W. Methylmercury directly modifies the 105th cysteine residue in oncostatin M to promote binding to tumor necrosis factor receptor 3 and inhibit cell growth. Arch. Toxicol. 97(7), 1887-1897, 2023. doi: 10.1007/s00204-023-03520-5.
  5. Lee J.Y., Kim J.M., Noguchi T., Matsuzawa A., Naganuma A., Hwang G.W. Deubiquitinase USP54 attenuates methylmercury toxicity in human embryonic kidney 293 cells. Fundam. Toxicol. Sci., 9, 159-162, 2022. LINK
  6. Mori C., Lee J.Y., Tokumoto M., Satoh M. Cadmium Toxicity Is Regulated by Peroxisome Proliferator-Activated Receptor δ in Human Proximal Tubular Cells. Int. J. Mol. Sci., 3, 23, 8652, 2022. LINK
  7. Kim J.M., Lee J.Y., Kim M.S., Shindo S., Kumagai T., Naganuma A., Hwang G.W. Knockdown of deubiquitinating enzyme Usp34 confers resistance to methylmercury in HEK293 cells. Fundam. Toxicol. Sci., 8, 157–160, 2021. LINK
  8. Mori C., Lee J.Y., Tokumoto M., Satoh M. Effect of Cadmium on the Expression of ABCB1 Transporter in Human Proximal Tubular Cells. BPB Rep., 4, 74–77, 2021. LINK
  9. Lee J.Y., Mori C., Tokumoto M., Satoh M. Time-dependent changes in the gene expression levels in the mouse kidney by long-term exposure to cadmium. BPB Rep., 4, 69-73, 2021. LINK
  10. Lee J.Y., Mori C., Tokumoto M., Satoh M. Changes in DNA-binding activity of transcription factors in the kidney of mice exposed to cadmium. J. Toxicol. Sci., 46, 125–129, 2021. LINK
  11. Lee J.Y., Tokumoto M., Satoh M. Cadmium toxicity mediated by the inhibition of SLC2A4 expression in human proximal tubule cells. FASEB J., 35, e21236, 2021. LINK
  12. Fujiwara Y.*, Lee J.Y.*, Banno H., Imai S., Tokumoto M., Hasegawa T., Seko Y., Nagase H., Satoh M. Cadmium induces iron deficiency anemia through the suppression of iron transport in the duodenum. Toxicol. Lett., 332, 130-139, 2020. *Co-first authors. LINK
  13. Sato M., Toyama T., Kim M.S., Lee, J.Y., Hoshi T., Miura N., Naganuma A., Hwang G.W. Increased putrescine levels due to ODC1 overexpression prevents mitochondrial dysfunction-related apoptosis induced by methylmercury. Life Sci., 256, 118031, 2020. LINK
  14. Toyama T., Xu S., Nakano R., Hasegawa T., Endo N., Takahashi T., Lee J.Y., Naganuma A., Hwang G.W. The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells. Cells, 9, 45, 2020. LINK
  15. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Effect of GATA transcription factors on cadmium toxicity in human proximal tubular cells. BPB Rep., 2, 25–28, 2019. LINK
  16. Hoshi T., Toyama T., Shinozaki Y., Koizumi S., Lee J.Y., Naganuma A., Hwang G.W. Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures. J. Toxicol. Sci., 44, 471–479, 2019. PDF
  17. Kim M.S., Takahashi T., Lee J.Y., Toyama T., Hoshi T., Kuge S., Fujiwara Y., Naganuma A., Hwang G.W. Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells. Sci. Rep., 9, 4631, 2019. PDF
  18. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Comprehensive analysis of BIRC family gene expression changes by mercury compounds and arsenic exposure in neuroblastoma, kidney, and hepatic cells. BPB Rep., 1, 20–24, 2018. PDF
  19. Lee J.Y., Tokumoto M., Hwang G.W., Kim M.S., Takahashi T., Naganuma A., Yoshida M., Satoh M. Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression. Toxics, 6, E48, 2018. PDF
  20. Kobayashi T., Toyama T., Lee J.Y., Miura N., Kuge S., Naganuma A., Hwang G.W. Methylmercury enhances cytotoxicity through inhibition of its activity by a decrease in PTEN solubility. BPB Rep., 1, 1–5, 2018. PDF
  21. Sato M., Toyama T., Lee J.Y., Miura N., Naganuma A., Hwang G.W. Activation of ornithine decarboxylase protects against methylmercury toxicity by increasing putrescine. Toxicol. Appl. Pharmacol., 356, 120–126, 2018. LINK
  22. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Effect of heat shock protein gene expression on cadmium toxicity in human proximal tubular cells. Fundam. Toxicol. Sci., 5, 93–97, 2018. PDF
  23. Sato M., Lee J.Y., Kim M.S., Takahashi T., Naganuma A. and Hwang G.W. Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells. Fundam. Toxicol. Sci., 5, 71–73, 2018. PDF
  24. Tokumoto M., Lee J.Y., Shimada A., Tohyama C., Satoh M. Glutathione has a more important role than metallothionein-I/II against inorganic mercury-induced acute renal toxicity. J. Toxicol. Sci., 43, 275280, 2018. PDF
  25. Sarma S. N., Saleem A., Lee J.Y., Tokumoto M., Hwang G.W., Chan H.M., Satoh M. Effects of long-term cadmium exposure on urinary metabolite profiles in mice. J. Toxicol. Sci., 43, 89–100, 2018. PDF
  26. Kurita H., Hasegawa T., Seko Y., Nagase H., Tokumoto M., Lee J.Y., Satoh M. Effect of gestational cadmium exposure on fetal growth, polyubiquitinated protein and monoubiqutin levels in the fetal liver of mice. J. Toxicol. Sci., 43, 19–24, 2018. PDF
  27. Yoshida M., Lee J.Y., Satoh M., Watanabe C. Neurobehavioral effects of postnatal exposure to low-level mercury vapor and/or methylmercury in mice. J. Toxicol. Sci., 43, 11–17, 2018. PDF
  28. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Effect of chronic cadmium exposure on the gene expression of Birc family in the mouse kidney and liver. Fundam. Toxicol. Sci., 4, 275-278, 2017. PDF
  29. Tokumoto M., Shibuya K., Lee J.Y., Tohyama C., Satoh M. Effect of metallothionein on ethanol-induced hepatotoxicity in mice. Fundam. Toxicol. Sci., 4, 269273, 2017. PDF
  30. Lee J.Y., Tokumoto M., Hwang G.W., Lee M.Y., Satoh M. Identification of ARNT-regulated BIRC3 as the target factor in cadmium renal toxicity. Sci. Rep., 7, 17287, 2017. PDF
  31. Kim M.S., Takahashi T., Lee J.Y., Miura N., Asanuma M., Hwang G.W., Naganuma A. Identification of transcription factors activated by methylmercury in mouse brain. Fundam. Toxicol. Sci., 4, 37–39, 2017. PDF
  32. Lee J.Y., Tokumoto M., Fujiwara Y., Hwang G.W., Lee M.Y., Satoh M. Sensitivity of MT-III null mice upon chronic exposure to cadmium. Fundam. Toxicol. Sci., 3, 285–289, 2016. PDF
  33. Lee J.Y., Tokumoto M., Hwang G.W., Satoh M. Cadmium-induced protein ubiquitination in UBA80 knockdown HK-2 cells. Fundam. Toxicol. Sci., 3, 281–284, 2016. PDF
  34. Kurita H., Nagase H., Tokumoto M., Lee J.Y., Satoh M. DNA microarray analysis of fetal liver of C57BL/6J mice exposed to cadmium during gestation. Fundam. Toxicol. Sci., 3, 257–280, 2016. PDF
  35. Park J.M., Chang K.H., Park K.H., Choi S.J., Lee K., Lee J.Y., Satoh M., Song S.Y., Lee M.Y. Differential Effects between Cigarette Total Particulate Matter and Cigarette Smoke Extract on Blood and Blood Vessel. Toxicol. Res., 32, 353–358, 2016. PDF
  36. Yoshida M., Lee J.Y., Shimizu-Furusawa H., Satoh M., Watanabe C. Neurobehavioral toxicity related to the exposure of weaning mice to low-level mercury vapor and methylmercury and influence of aging. Fundam. Toxicol. Sci., 3, 185–193, 2016. PDF
  37. Lee J.Y., Tokumoto M., Fujiwara Y., Hasegawa T., Seko Y., Shimada A., Satoh M. Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity. Sci. Rep., 6, 21968, 2016. PDF
  38. Lee J.Y., Ishida Y., Takahashi T., Naganuma A., Hwang G.W. Transport of pyruvate into mitochondria is involved in methylmercury toxicity. Sci. Rep., 6, 21528, 2016. PDF
  39. Lee J.Y., Tokumoto M., Hattori Y., Fujiwara Y., Shimada A., Satoh M. Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes. Toxicol. Res. 32, 73–80, 2016. PDF
  40. Park J.M., Lee J.H., Na C.S., Lee D., Lee J.Y., Satoh M., Lee M.Y. Heartwood Extract of Rhus verniciflua Stokes and Its Active Constituent Fisetin Attenuate Vasoconstriction through Calcium-dependent Mechanism in Rat Aorta. Biosci. Biotechnol. Biochem., 80, 493–500, 2016. LINK
  41. Lee J.Y., Tokumoto M., Satoh M. The enhancement effect of HIST1H4C knockdown on cadmium toxicity in human proximal tubular cells. Fundam. Toxicol. Sci., 2, 259–262, 2015. PDF
  42. Lee J.Y., Tokumoto M., Fujiwara Y., Satoh M. Involvement of ubiquitin-coding genes in cadmium-induced protein ubiquitination in human proximal tubular cells. J. Toxicol. Sci. 40, 901–908, 2015. PDF
  43. Lee J.Y., Ishida Y., Kuge S., Naganuma A., Hwang G.W. Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells. FEBS Lett., 589, 2720–2725, 2015. PDF
  44. Lee J.Y., Tokumoto M., Fujiwara Y., Lee M.Y., Satoh M. The involvement of GPRC5B in cadmium toxicity in HK-2 cells. Fundam. Toxicol. Sci., 1, 165–167, 2014. PDF
  45. Lee J.Y., Tokumoto M., Fujiwara Y., Lee M.Y., Satoh M. Effects of cadmium on the gene expression of SLC39A1 coding for ZIP1 protein. Fundam. Toxicol. Sci., 1, 131–133, 2014. PDF
  46. Tokumoto M., Lee J.Y., Fujiwara Y., Satoh M. Alteration of DNA binding activity of transcription factors in NRK-52E rat proximal tubular cells treated with cadmium. J. Toxicol. Sci., 39, 735–738, 2014. PDF
  47. Imai S., Tokumoto M., Fujiwara Y., Hasegawa T., Seko Y., Lee J.Y., Nagase H., Satoh M. Gene expression differences in the duodenum of 129/Sv and DBA/2 mice compared with that of C57BL/6J mice. J. Toxicol. Sci., 39, 173–177, 2014. PDF
  48. Takahashi T., Kim M.S., Saito T., Lee J.Y., Hwang G.W., Naganuma A. Brain-specific induction of secretoglobin 3A1 expression in mice treated with methylmercury. J. Toxicol. Sci., 38, 963–965, 2013. PDF
  49. Lee J.Y., Tokumoto M., Fujiwara Y., Satoh M. Gene expression analysis using DNA microarray in HK-2 human renal proximal tubular cells treated with cadmium. J. Toxicol. Sci., 38, 959–962, 2013. PDF
  50. Kim M.S., Takahashi T., Lee J.Y., Hwang G.W., Naganuma A. Global chemokine expression in methylmercury-treated mice: methylmercury induces brain-specific expression of CCL3 and CCL4. J. Toxicol. Sci., 38, 925–929, 2013. PDF
  51. Tokumoto M., Lee J.Y., Fujiwara Y., Uchiyama M., Satoh M. Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells. J. Toxicol. Sci., 38, 815–820, 2013. PDF
  52. Tokumoto M., Lee J.Y., Fujiwara Y., Satoh M. DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months. J. Toxicol. Sci., 38, 799–802, 2013. PDF
  53. Hwang G.W., Lee J.Y., Kim M.S., Sato M., Takahashi T.,Naganuma A. Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury. J. Toxicol. Sci., 38, 703–706, 2013. PDF
  54. Hwang G.W., Mastuyama F., Takahashi T., Lee J.Y., Naganuma A. Deletion of the ubiquitin-conjugating enzyme Ubc2 confers resistance to methylmercury in budding yeast by promoting Whi2 degradation. J. Toxicol. Sci., 38, 301–303, 2013. PDF
  55. Kim M.S., Takahashi T., Lee J.Y., Hwang G.W., Naganuma A. Methylmercury induces CCL2 expression through activation of NF-κB in human 1321N1 astrocytes. J. Toxicol. Sci., 37, 1275–1278, 2012. PDF
  56. Lee J.Y., Hwang G.W., Kim M.S., Takahashi T., Naganuma A. Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice. J. Toxicol. Sci., 37, 1279–1282, 2012. PDF
  57. Hwang G.W., Kimura Y., Takahashi T., Lee J.Y., Naganuma A. Identification of deubiquitinating enzymes involved in methylmercury toxicity in Saccharomyces cerevisiae. J. Toxicol. Sci., 37, 1287–1290, 2012. PDF
  58. Tsuruma K., Shimazaki H., Ohno Y., Inoue Y., Honda A., Imai S., Lee J.Y., Shimazawa M., Satoh M., Hara H. Metallothionein-III Deficiency Exacerbates Light-Induced Retinal Degeneration. Invest. Ophthalmol. Vis. Sci., 53, 7896–7903, 2012. PDF
  59. Yokomakura A, Hong J, Ohuchi K, Oh S.E., Lee J.Y., Mano N, Takahashi T, Hwang G.W., Naganuma A. Increased production of reactive oxygen species by the vacuolar-type (H(+))-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells. J. Toxicol. Sci., 37, 1045–1048, 2012. PDF
  60. Hwang G.W., Ryoke K., Lee J.Y., Takahashi T., Naganuma A. siRNA-mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells. J. Toxicol. Sci., 36, 851–853, 2011. PDF
  61. Hwang G.W., Lee J.Y., Ryoke K., Matsuyama F., Kim J.M., Takahashi T., Naganuma A. Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury. J. Toxicol. Sci., 36, 389–391, 2011. PDF 〜平成26年度 日本毒性学会・ファイザー賞受賞論文〜
  62. Hwang G.W., Oh S.E., Takahashi T., Lee J.Y., Naganuma A. siRNA-mediated knockdown of the melanocortin 2 receptor accessory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK293 cells. J. Toxicol. Sci., 35, 947–950, 2010. PDF
  63. Lee J.Y., Hwang G.W., Naganuma A. Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS) in budding yeast. J. Toxicol. Sci., 34, 715–717, 2009. PDF


総 説
  1. 佐藤雅彦,李 辰竜,徳本真紀,本田晶子,藤原泰之.カドミウム毒性発現分子機構とその防御.愛知学院大学薬学会誌,13, 1–10, 2020. PDF
  2. Lee, J.Y., Hwang G.W., Naganuma A., Satoh M. Methylmercury Toxic Mechanism Related to Protein Degradation and Chemokine Transcription. Environ. Health Prev. Med., 25, 30, 2020. PDF
  3. Tokumoto M., Lee J.Y., Satoh M. Transcription Factors and Downstream Genes in Cadmium Toxicity. Biol. Pharm. Bull., 42, 1083–1088, 2019. PDF
  4. Fujiwara Y., Lee J.Y., Tokumoto M., Satoh M. Cadmium renal toxicity via apoptotic pathways. Biol. Pharm. Bull., 35, 1892–1897, 2012. PDF

著 書
  1. 李辰竜(編集・分担執筆).必携・衛生試験法 第3版,日本薬学会 編,金原出版,東京,2021.
  2. Lee J.Y., Tokumoto M., Satoh M. Novel Mechanisms of Cadmium-Induced Toxicity in Renal Cells. In: Cadmium Toxicity, Springer Nature, Switzerland, pp153–162, 2019. LINK
  3. 李辰竜(編集・分担執筆).必携・衛生試験法 第2版,日本薬学会 編,金原出版,東京,2016.
そ の 他
  1. 李辰竜.公害の歴史から実行すべきこと.「第5回 日本人が知らないJAPAN」.ファルマシア,55, 1162, 2019. LINK
  2. 李辰竜.ビタミンEの過剰摂取と骨粗しょう症.環境・衛生薬学トピックス.日本薬学会 環境・衛生部会.LINK
  3. 李辰竜.なぜ、ω-3脂肪酸は強力な抗炎症作用および高肥満作用を示すか.ファルマシア, 47, 537-538, 2011. LINK