外書講読 I・II


  • 令和5年度（2023年度）
  • 三浦尚之　　Recent Clinical and Epidemiological Studies of Itai-Itai Disease (Cadmium-Induced Renal Tubular Osteomalacia) and Cadmium Nephropathy in the Jinzu River Basin in Toyama Prefecture, Japan. Aoshima, K. (2019). In: Himeno, S., Aoshima, K. (eds) Cadmium Toxicity. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore.
  • 籾山虎之介　　Dietary Cadmium Intake Among General Populations in Japan and East Asia. Ikeda, M. et al. (2019). In: Himeno, S., Aoshima, K. (eds) Cadmium Toxicity. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore.
  • 米谷光平　　Novel Pathological Study of Cadmium Nephropathy of Itai-itai Disease. Imura, J., Tsuneyama, K., Ueda, Y. (2019). In: Himeno, S., Aoshima, K. (eds) Cadmium Toxicity. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore.
  • 花澤裕貴　　Live and Let Die: Roles of Autophagy in Cadmium Nephrotoxicity. Thévenod F, Lee W-K. Toxics. 2015; 3(2):130-151.
  • 森北あゆ　　Metallothionein in Brain Disorders. Juárez-Rebollar D, Rios C, Nava-Ruíz C, Méndez-Armenta M. Oxid Med Cell Longev. 2017; 2017:5828056.
  • 粟津賢人　　Microplastics may increase the environmental risks of Cd via promoting Cd uptake by plants: A meta-analysis. Huang F, Hu J, Chen L, Wang Z, Sun S, Zhang W, Jiang H, Luo Y, Wang L, Zeng Y, Fang L. J Hazard Mater. 2023 Apr 15;448:130887.
  • 金子裕也　　Metallothionein and Cadmium Toxicology—Historical Review and Commentary. Nordberg M, Nordberg GF. Biomolecules. 2022; 12(3):360.
  • 左髙帆乃実　　Cadmium induced BEAS-2B cells apoptosis and mitochondria damage via MAPK signaling pathway. Cao X., Fu M., Bi R., Zheng X., Fu B., Tian S., Liu C., Li Q., Liu J. Chemosphere, 263, 128346, 2021.
  • 田中優至　　Historical Lessons on Cadmium Environmental Pollution Problems in Japan and Current Cadmium Exposure Situation. Aoshima, K., Horiguchi, H. (2019). In: Himeno, S., Aoshima, K. (eds) Cadmium Toxicity. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore.
  • 寺本玲雄　　Heavy Metal Contamination in the Aquatic Ecosystem: Toxicity and Its Remediation Using Eco-Friendly Approaches. Singh V, Singh N, Rai SN, Kumar A, Singh AK, Singh MP, Sahoo A, Shekhar S, Vamanu E, Mishra V. Toxics. 2023; 11(2):147.
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  • 令和4年度（2022年度）
  • 小林日菜　　Whole life exposure to low dose cadmium alters diet-induced NAFLD. Young J. L., Cave M. C., Xu Q., Kong M., Xu J., Lin Q., Tan Y., Cai L. Toxicol. Appl. Pharmacol., 436, 115855, 2022.
  • 成瀬智将　　Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival. Masiulionytė B., Valiulytė I., Tamašauskas A., Skiriutė D. Sci Rep., 9, 5406, 2019.
  • 平出幹人　Low-Dose Methylmercury-Induced Genes Regulate Mitochondrial Biogenesis via miR-25 in Immortalized Human Embryonic Neural Progenitor Cells. Wang X., Yan M., Zhao L., Wu Q., Wu C., Chang X., Zhou Z. Int. J. Mol. Sci., 17, 2058, 2016.
  • 牧　亜祐　　 Relationship between blood test values and blood lead (Pb) levels in Black-headed gull (Chroicocephalus ridibundus: Laridae). Ushine N., Nakayama S. M. M., Ishizuka M., Sato T., Kurahashi Y., Wakayama E., Sugiura N., Hayama S. Vet. Med. Sci. 82, 1124–1129, 2022.
  • 和田薫乃　　GSK-3β-mediated regulation of cadmium-induced cell death and survival. Kim S., Cheon H., Kim S.M., Kim Y.Y. Cell. Mol. Biol. Lett., 23, 9, 2018.
  • 植田泰朗　　Evidence that Pacific tuna mercury levels are driven by marine methylmercury production and anthropogenic inputs. Médieu A., Point D., Itai T., Angot H., Buchanan P. J., Allain V., Fuller L., Griffiths S., Gillikin D. P., Sonke J. E., Heimbürger-Boavida L., Desgranges M., Menkes C. E., Madigan D. J., Brosset P., Gauthier O., Tagliabue A., Bopp L. , Verheyden A., Lorrain A. Proc. Natl. Acad. Sci. USA, 119, e2113032119, 2022.
  • 宇田龍馬　　 Effect of cell cycle synchronization on cadmium-induced apoptosis and necrosis in NRK-52E cells. Luo T., Yu Q., Dong W., Gong Z., Tan Y., Liu W., Zou H., Gu J., Yuan Y., Bian J., Shao C., Zhu J., Liu Z. Cell Cycle. 19, 3386–3397, 2020.
  • 大霜光輝　　Detailed Analysis of Neurological Symptoms and Sensory Disturbances Due to Chronic Arsenic Exposure in Toroku, Japan. Sugiyama T., Ishii N., Ebihara Y., Shiomi K., Mochizuki H. Int. J. Environ. Res. Public Health, 18, 10749, 2021.
  • 和氣大成　　Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. Lee H.Y., Oh S.H. Biochem. Biophys. Res. Commun., 534:128–133, 2021.



  • 令和3年度（2021年度）
  • 髙橋真理　　Epalrestat suppresses cadmium-induced cytotoxicity through Nrf2 in endothelial cells. Tatsunami R., Sato K., Murao Y., Yama K., Yu Y., Ohno S., Tampo Y. 21, 393. 2021.
  • 阿部亮平　　Assessment of In Vitro Bioaccessibility and In Vivo Oral Bioavailability as Complementary Tools to Better Understand the Effect of Cooking on Methylmercury, Arsenic, and Selenium in Tuna. Charette T., Bueno Dalto D., Rosabal M., Matte J. J., Amyot M. Toxics. 9, 27, 2021.
  • 高井玲菜　　Low Doses of Methylmercury Induce the Proliferation of Thyroid Cells In Vitro Through Modulation of ERK Pathway. Maggisano V., Bulotta S., Celano M., Maiuolo J., Lepore S. M., Abballe L., Iannone M., Russo D. Int. J. Mol. Sci., 21, 1556, 2020.
  • 高山雄介　　Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma. Rodrigo M. A.M., Michalkova H., Strmiska V., Casar B., Crespo P., de Los Rios V., Ignacio Casal J., Haddad Y., Guran R., Eckschlager T., Pokorna P., Heger Z., Adam V. Sci. Rep., 11, 5496, 2021.
  • 塚本健太　　Involvement of metal transporters in the intestinal uptake of cadmium. Ohta H., Ohba K. J. Toxicol. Sci., 45, 539–548, 2020.
  • 伝田尚人　　Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14. Widhalm R., Ellinger I., Granitzer S., Forsthuber M., Bajtela R., Gelles K., Hartig P.Y., Hengstschläger M., Zeisler H., Salzer H., Gundacker C. Metallomics. 1, 121822–1833, 2020.



  • 令和2年度（2020年度）
  • 太田ひかる　　Metallothioneins Regulate ATP7A Trafficking and Control Cell Viability During Copper Deficiency and Excess. Gudekar N., Shanbhag V., Wang Y., Ralle M., Weisman G.A., Petris M.J. Sci. Rep., 10, 7856, 2020.
  • 神谷英渡　　Intrauterine Exposure to Cadmium Reduces HIF-1 DNA-Binding Ability in Rat Fetal Kidneys. Jacobo-Estrada T., Cardenas-Gonzalez M., Santoyo-Sánchez M.P., Thevenod F., Barbier O. Toxics, 6, 53, 2018.
  • 瀧川彩菜　　Segment-specific and Direction-Dependent Transport of Cadmium and Manganese in Immortalized S1, S2, and S3 Cells Derived From Mouse Kidney Proximal Tubules. Fujishiro H., Hamao S., Isawa M., Himeno S. J. Toxicol. Sci., 44, 611–619, 2019.
  • 梅澤健杜　　Lethal chronotoxicity induced by seven metal compounds in mice. Yoshioka H., Nonogaki T., Shinohara Y., Suzui M., Mori Y., Hwang G.W., Ohtani K., Miura N. J. Toxicol. Sci., 43, 129–134, 2018.
  • 花村日向子　　Selenocystine against methyl mercury cytotoxicity in HepG2 cells. Wang H., Chen B., He M., Yu X., Hu B. Sci. Rep., 7, 147, 2017.
  • 山﨑友寛　　Reproductive effects of cadmium on sperm function and early embryonic development in vitro. Zhao L.L., Ru Y.F., Liu M., Tang J.N., Zheng J.F., Wu B., Gu Y.H., Shi H.J. PLoS One, 12, e0186727, 2017.
  • 石井　涼　　In situ different antioxidative systems contribute to the site-specific methylmercury neurotoxicity in mice. Fujimura M., Usuki F. Toxicology, 392, 55–63, 2017.
  • 上仮屋剛　　Cadmium and High-fat Diet Disrupt Renal, cardiac and Hepatic Essential Metals. Young J.L., Yan X., Xu J., Yin X., Zhang X., Arteel G.E., Barnes G.N., States J.C., Watson W.H., Kong M., Cai L., Freedman J.H. Sci. Rep., 9, 14675, 2019.



  • 平成31年度（2019年度）
  • 丹羽裕哉　　The modifying effect of kidney function on the association of cadmium exposure with blood pressure and cardiovascular mortality-NHANES 1999–2010. Gao Y., Zhu X., Shrubsole M.J., Fan L., Xia Z., Harris R.C., Hou L., Dai Q. Toxicol. Appl. Pharmacol., 353, 15–22, 2018.
  • 日當瀬雅大　　Prenatal low-dose methylmercury exposure impairs neurite outgrowth and synaptic protein expression and suppresses TrkA pathway activity and eEF1A1 expression in the rat cerebellum. Fujimura M., Usuki F., Cheng J., Zhao W. Toxicol. Appl. Pharmacol., 298, 1–8, 2016.
  • 水野沙紀　　Methylmercury exposure causes a persistent inhibition of myogenin expression and C2C12 myoblast differentiation. Prince L.M., Rand M.D. Toxicology, 393, 113–122, 2018.
  • 篠原武志　　Protective Effect of Selenium-Enriched Ricegrass Juice against Cadmium-Induced Toxicity and DNA Damage in HEK293 Kidney Cells. Chomchan R., Siripongvutikorn S., Maliyam P., Saibandith B., Puttarak P. Foods, 7, 81, 2018.
  • 久留宮朱理　　Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney. Andjelkovic M., Buha Djordjevic A., Antonijevic E., Antonijevic B., Stanic M., Kotur-Stevuljevic J., Spasojevic-Kalimanovska V., Jovanovic M., Boricic N., Wallace D., Bulat Z. Int. J. Environ. Res. Public Health., 16, E274 , 2019.
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平成30年度（2018年度）
  • 纐纈陽菜　　Concentration-dependent roles of DMT1 and ZIP14 in cadmium absorption in Caco-2 cells. Fujishiro H., Hamao S., Tanaka R., Kambe T., Himeno S. J. Toxicol. Sci., 42, 559–567, 2017.
  • 久野泰治　　Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity. Luo J., Gurung S., Lee L., Henley J.M., Wilkinson K.A., Guo C. J. Toxicol. Sci., 42, 529–538, 2017.
  • 橋本英樹　　Multidirectional analyses of hepatic chronotoxicity induced by cadmium in mice. Miura N., Yoshioka H., Ashimori A., Ohtani K., Hasegawa T., Hwang G.W., Ikeda M., Nonogaki T. J. Toxicol. Sci., 42, 597–604, 2017.
  • 奥村嘉浩　　Relationship between mortality and rice cadmium concentration in inhabitants of the polluted Jinzu River basin, Toyama, Japan: A 26 year follow-up. Comes G., Manso Y., Escrig A., Fernandez-Gayol O., Sanchis P., Molinero A., Giralt M., Carrasco J., Hidalgo J. J. Appl. Toxicol., 38, 855–861, 2018.
  • 石川貴都　　N-acetylcysteine alleviates cadmium-induced placental endoplasmic reticulum stress and fetal growth restriction in mice. Guo M.Y., Wang H., Chen Y.H., Xia M.Z., Zhang C., Xu D.X. PLoS One, 13, e0191667, 2018.
  • 杉浦優志　　Methylmercury induces the expression of TNF-α selectively in the brain of mice. Iwai-Shimada M., Takahashi T., Kim M.S., Fujimura M., Ito H., Toyama T., Naganuma A., Hwang G.W. Sci Rep., 6, 38294, 2016.
  • 林　航介　　Metallothionein, glutathione, and cystine transport in pulmonary artery endothelial cells and NIH/3T3 cells. Susanto I., Wright S.E., Lawson R.S., Williams C.E., Deneke S.M. Am. J. Physiol., 274, L296–300, 1998.
  • 可児隼大　　Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity. Yoshida E., Kurita M., Eto K., Kumagai Y., Kaji T. Toxicology, 392, 40–46, 2017.

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平成29年度（2017年度）
  • 谷川敬明　　NF-kB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells. Zhang H., Li L., Wang Y., Dong F., Chen X., Liu F., Xu D., Yi F., Kapron C.M., Liu J. Int. J. Mol. Med., 35, 417–422, 2016.
  • 中村太亮　　Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells. Fujie T., Segawa Y., Kimura T., Fujiwara Y., Yamamoto C., Satoh M., Naka H., Kaji T. J. Toxicol. Sci., 41, 225–232, 2016.
  • 森　稚景　　Carbon Tetrachloride-Induced Nephrotoxicity in Mice Is Prevented by Pretreatment with Zinc Sulfate. Yoshioka H., Usuda H., Fukuishi N., Nonogaki T., Onosaka S. Biol. Pharm. Bull., 39, 1042–1046, 2016.
  • 則武大輝　　Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer’s Disease. Comes G., Manso Y., Escrig A., Fernandez-Gayol O., Sanchis P., Molinero A., Giralt M., Carrasco J., Hidalgo J. Int. J. Mol. Sci., 18, 251, 2017.
  • 村田大樹　　Induction and Determination of Apoptotic and Necrotic Cell Death by Cadmium Chloride in Testis of Mouse. Niknafs B., Salehnia M., Kamkar M. J. Reprod. Infertil., 16, 24–29, 2015.



平成28年度（2016年度）
  • 近藤正規　　Partial Contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells. Shinkai Y., Kimura T., Itagaki A., Yamamoto C., Taguchi K., Yamamoto M., Kumagai Y., Kaji T. Toxicol. Appl. Pharmacol., 295, 37–46, 2016.
  • 森　麻友佳　　Carbon tetrachloride-induced lethality in mouse is prevented by multiple pretreatment with zinc sulfate. Yoshioka H., Usuda H., Nonogaki T., Onosaka S. J. Toxicol. Sci., 41, 55–63, 2016.
  • 白鳥義貴　　Alpha-lipoic acid protects against cadmium-induced hepatotoxicity via calcium signalling and gap junctional intercellular communication in rat hepatocytes. Zou H., Liu X., Han T., Hu D., Yuan Y., Gu J., Bian J., Liu Z. J. Toxicol. Sci., 40, 469–477, 2015.
  • 小長谷直史　　Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure. Qu W., Waalkes M.P. Toxicol. Appl. Pharmacol., 282, 267–274, 2015.
  • 道家　瞳　　Endothelial dysfunction in subjects with chronic cadmium exposure. Lukkhananan P., Thawonrachat N., Srihirun S., Swaddiwudhipong W., Chaturapanich G., Vivithanaporn P., Unchern S., Visoottiviseth P., Sibmooh N. J. Toxicol. Sci., 40, 605–613, 2015.
  • 滝　将希　　Superoxide produced in the matrix of mitochondria enhances methylmercury toxicity in human neuroblastoma cells. Mailloux R.J., Yumvihoze E., Chan H.M. Toxicol. Appl. Pharmacol., 289, 371–380, 2015.
  • 柿澤　諒　　Evaluation of cystatin C as an early biomarker of cadmium nephrotoxicity in the rat. Prozialeck W.C., VanDreel A., Ackerman C.D., Stock I., Papaeliou A., Yasmine C., Wilson K., Lamar P.C., Sears V.L., Gasiorowski J.Z., DiNovo K.M., Vaidya V.S., Edwards J.R. Biometals, 29, 131–146, 2016.

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平成27年度（2015年度）
  • 高杉義道　　Metallothionein isoform 3 expression in human skin, related cancers and human skin derived cell cultures. Slusser A., Zheng Y., Zhou X.D., Somji S., Sens D.A., Sens M.A., Garrett S.H. Toxicol. Lett., 232, 141–148, 2015.
  • 家田学幸　　Water management affects arsenic and cadmium accumulation in different rice cultivars. Hu P., Huang J., Ouyang Y., Wu L., Song J., Wang S., Li Z., Han C., Zhou L., Huang Y., Luo Y., Christie P. Environ. Geochem. Health, 35, 767–778, 2013.
  • 野田雄大　　CDC23 knockdown reinforces methylmercury sensitivity in HEK293 cells. Du K., Takahashi T., Iwai-Shimada M., Miura N., Naganuma A., Hwang G.W. Fundam. Toxicol. Sci., 1, 161–164, 2014.
  • 木俣隆太郎　　Metallothionein blocks oxidative DNA damage induced by acute inorganic arsenic exposure. Qu W., Waalkes M.P. Toxicol. Appl. Pharmacol., 282, 267–274, 2015.
  • 久田成美　　Cadmium activates a programmed, lysosomal membrane permeabilization-dependent necrosis pathway. Messner B., Ploner C., Laufer G., Bernhard D. Toxicol. Lett., 212, 268–275, 2012.
  • 山口雄三　　Sub-chronic lead and cadmium co-induce apoptosis protein expression in liver and kidney of rats. Yuan G., Dai S., Yin Z., Lu H., Jia R., Xu J., Song X., Li L., Shu Y., Zhao X., Chen Z., Fan Q., Liang X., He C., Yin L., Lv C., Lei Q., Wang L., Mi Y., Yu X., Zhang M. Int. J. Clin. Exp. Pathol., 7, 2905–2914, 2014.
  • 石原友美　　Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease. Baba H., Tsuneyama K., Kumada T., Aoshima K., Imura J. J. Toxicol. Sci., 39, 91–96, 2014.
  • 新海裕正　　Cadmium exposure inhibits MMP2 and MMP9 activities in the prostate and testis. Lacorte L.M., Rinaldi J.C., Justulin L.A. Jr., Delella F.K., Moroz A., Felisbino S.L. Biochem. Biophys. Res. Commun., 457, 538–541, 2015.

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平成26年度（2014年度）外書講読論文
外書講読 II
  • 近藤秀治　　Co-exposure to lead increases the renal response to low levels of cadmium in metallurgy workers. Hambach R., Lison D., D'Haese P.C., Weyler J., De Graef E., De Schryver A., Lamberts L.V., van Sprundel M. Toxicol. Lett., 222, 233–238, 2013.
  • 渡辺稚佐登　　Quantification of oxidative stress in live mouse embryonic fibroblasts by monitoring the responses of polyubiquitin genes. Ryu H.W., Ryu K.Y. Biochem. Biophys. Res. Commun., 404, 470–475, 2011.
  • 須田克麻　　Availability of Heavy Metals (Cd, Pb, and Cr) in Agriculture from Commercial Fertilizers. Nacke H., Gonçalves A.C. Jr., Schwantes D., Nava I.A., Strey L., Coelho G.F. Arch. Environ. Contam. Toxicol., 64, 537–544, 2013.
  • 淺井健二郎　　Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells. Person R.J., Tokar E.J., Xu Y., Orihuela R., Ngalame N.N., Waalkes M.P. Toxicol. Appl. Pharmacol., 273, 281–288, 2013.
  • 山田まなみ　　Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing. Park B.H., Kim H.G., Jin S.W., Song S.G., Jeong H.G. FEBS. Lett., 588, 2294–2300, 2014.
  • 原　謙一　　Mercury species in lymphoid and non-lymphoid tissues after exposure to methyl mercury: Correlation with autoimmune parameters during and after treatment in susceptible mice. Havarinasab S., Björn E., Nielsen J.B., Hultman P. Toxicol. Appl. Pharmacol., 221, 21–28, 2007.
  • 飯田英里　　Increase male genital diseases morbidity linked to informal electronic waste recycling in Guiyu, China.Xu X., Zhang Y., Yekeen T.A., Li Y., Zhuang B., Huo X. Environ. Sci. Pollut. Res. Int., 21, 3540–3545, 2014.
  • 長谷川博之　　Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism. Mukwevho E., Kohn T.A., Lang D., Nyatia E., Smith J., Ojuka E.O. Am. J. Physiol. Endocrinol. Metab., 294, 582–588, 2008.
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外書講読 I
  • 長谷川博之　　Dose methylmercury-induced hypercholesterolemia play a causal role in its neurotoxicity and cardiovascular disease?. Moreira E.L., de Oliveira J., Dutra M.F., Santos D.B., Gonçalves C.A., Goldfeder E.M., de Bem A.F., Prediger R.D., Aschner M., Farina M. Toxicol. Sci., 130, 373–382, 2012.
  • 須田克麻　　Low dose of methyl mercury (MeHg) exposure induces caspase mediated-apoptosis in cultured neural progenitor cells. Watanabe J., Nakamachi T., Ohtaki H., Naganuma A., Shioda S., Nakajo S. J. Toxicol. Sci., 38, 931–935, 2013.
  • 近藤秀治　　Benchmark dose of cadmium concentration in rice for renal effects in a cadmium-polluted area in Japan. Nogawa K., Kido T., Nishijo M., Nakagawa H., Suwazono Y. J. Appl. Toxicol., 35, 24-28, 2015.
  • 渡辺稚佐登　　Protective effects of quercetin on cadmium-induced cytotoxicity in primary cultures of rat proximal tubular cells. Wang L., Lin S.Q., He Y.L., Liu G., Wang Z.Y. Biomed. Environ. Sci., 26, 258–267, 2013.
  • 淺井健二郎　　Cadmium induces cytotoxicity in human bronchial epithelial cells through up regulation of eIF5A1 and NF-kappaB. Chen D.J., Xu Y.M., Du J.Y., Huang D.Y., Lau A.T. Biochem. Biophys. Res. Commun., 445, 95–99, 2014.
  • 山田まなみ　　Effects of subchronic exposure to lead acetate and cadmium chloride on rat’s bone: Ca and Pi contents, bone density, and histopathological evaluation. Lu H., Yuan G., Yin Z., Dai S., Jia R., Xu J., Song X., Li L., Lv C. Int. J. Clin. Exp. Pathol., 7, 640–647, 2014.
  • 原　謙一　　Effects of Cd2+ on cis-dimer structure of E-cadherin in living cells. Takeda H. Biochem. Biophys. Res. Commun., 444, 467–472, 2014.
  • 飯田英里　　Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease. Baba H., Tsuneyama K., Kumada T., Aoshima K., Imura J. J. Toxicol. Sci., 39, 91–96, 2014.
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平成25年度（2013年度）外書講読論文
外書講読 II
  • 上村幸央　　Methylmercury induces caspase-dependent apoptosis and autophagy in human neural stem cells. Chang S.H., Lee H.J., Kang B., Yu K.N., Minai-Tehrani A., Lee S., Kim S.U., Cho M.H. Environ. J. Toxicol. Sci., 38, 823–831, 2013.
  • 溝口　遼　　Hair mercury levels in Amazonian populations: spatial distribution and trends. Barbieri F.L., Gardon J. Int. J. Health Geogr., 8, 71, 2009.
  • 森　健景　　Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium. Fujiki K., Inamura H., Matsuoka M. Arch. Toxicol., 87, 2119–2127, 2013.
  • 成木万理子　　Chronic mercury poisoning. 1946. Buckell M., Hunter D., Milton R., Perry K.M. Br. J. Ind. Med., 50, 97–106, 1993.
  • 宮脇　希　　The association between blood pressure and blood cadmium in a Chinese population living in cadmium polluted area. Chen X., Zhu G., Lei L., Jin T. Environ. Toxicol. Pharmacol., 36, 595–599, 2013.
  • 古川洋光　　Cadmium, vectorial active transport, and MT-3-dependent regulation of cadherin expression in human proximal tubular cells. Bathula C.S., Garrett S.H., Zhou X.D., Sens M.A., Sens D.A., Somji S. Toxicol. Sci., 102, 310–318, 2008.
  • 喜畑敬介　　A Zn(II)-glycine complex suppresses UVB-induced melanin production by stimulating metallothionein expression. Ochiai Y., Kaburagi S., Okano Y., Masaki H., Ichihashi M., Funasaka Y., Sakurai H. Int. J. Cosmet Sci., 30, 105–112, 2008.
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外書講読 I
  • 上村幸央　　Distribution and chemical form of mercury in commercial fish tissues. Watanabe N., Tayama M., Inouye M., Yasutake A. J. Toxicol. Sci., 37, 853–861, 2012.
  • 溝口　遼　　Participation of metal transporters in cadmium transport from mother rat to fetus. Nakamura Y., Ohba K., Ohta H. J. Toxicol. Sci., 37, 1035–1044, 2012.
  • 森　健景　　Propolis suppresses CdCl₂-induced cytotoxicity of COS7 cells through the prevention of intracellular reactive oxygen species accumulation. Biol. Pharm. Bull., 35, 1126–1131, 2012.
  • 成木万理子　　Influence of injection timing on severity of cadmium-induced testicular toxicity in mice. Ohtani K., Yanagiba Y., Ashimori A., Takeuchi A., Takada N., Togawa M., Hasegawa T., Ikeda M., Miura N. J. Toxicol. Sci., 38, 145–150, 2013.
  • 宮脇　希　　Involvement of the essential metal transporter Zip14 in hepatic Cd accumulation during inflammation. Min K.S., Takano M., Amako K., Ueda H., Tanaka K. Toxicol. Lett., 218, 91–96, 2013.
  • 古川洋光　　The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of Aβ(1-42) with Cu ions. Luo Y., Xu Y., Bao Q., Ding Z., Zhu C., Huang Z.X., Tan X. J. Biol. Inorg. Chem., 18, 39–47, 2013.
  • 喜畑敬介　　Role of Arf1 in endosomal trafficking of protein-metal complexes and cadmium-metallothionein-1 toxicity in kidney proximal tubule cells. Wolff N.A., Lee W.K., Thévenod F. Toxicol. Lett., 203, 210–218, 2013.
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平成24年度（2012年度）外書講読論文
外書講読 II
  • 井内文哉　　Renal function after reduction in cadmium exposure: an 8‐year follow‐up of residents in cadmium‐polluted areas. Liang Y., Lei L., Nilsson J., Li H., Nordberg M., Bernard A., Nordberg G.F., Bergdahl I.A., Jin T. Environ. Health Perspect., 120, 223–228, 2012.
  • 石川裕介　　Activation of HIF-1 by metallothionein contributes to cardiac protection in the diabetic heart. Xue W., Liu Y., Zhao J., Cai L., Li X., Feng W. Am. J. Physiol. Heart Circ. Physiol., 302, H2528–2535, 2012.
  • 玉川明弘　　Nrf2 activation prevents cadmium-induced acute liver injury. Wu K.C., Liu J.J., Klaassen C.D. Toxicol. Appl. Pharmacol., 263, 14–20, 2012.
  • 中尾康佑　　Cadmium induces p53-dependent apoptosis in human prostate epithelial cells. Aimola P., Carmignani M., Volpe A.R., Di Benedetto A., Claudio L., Waalkes M.P., van Bokhoven A., Tokar E.J., Claudio P.P. PLoS ONE, 7, e33647, 2012.
  • 西山雄一郎　　Role of zinc metallothionein-3 (ZnMt3) in epidermal growth factor (EGF)-induced c-Abl protein activation and actin polymerization in cultured astrocytes. Lee S.J., Cho K.S., Kim H.N., Kim H.J., Koh J.Y. J. Biol. Chem., 286, 40847–40856, 2011.
  • 志賀大輝　　Cross-resistance of cadmium-resistant cells to manganese is associated with reduced accumulation of both cadmium and manganese. Fujishiro H., Kubota K., Inoue D., Inoue A., Yanagiya T., Enomoto S., Himeno S. Toxicology, 280, 118–125, 2011.
  • 久野晃子　　Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo. Onodera A., Tani M., Michigami T., Yamagata M., Min K.S., Tanaka K., Nakanishi T., Kimura T., Itoh N. Toxicol. Lett., 212, 91–96, 2012.
  • 平手琢真　　Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. Fujishiro H., Yano Y., Takada Y., Tanihara M., Himeno S. Metallomics, 4, 700–708, 2012.

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外書講読 I
  • 井内文哉　　Antioxidant effects of heated garlic juice on cadmium-induced liver damage in rats as compared to ascorbic acid. Olalekan Lawal A., Lawal A.F., Ologundudu A., Adeniran O.Y., Omonkhua A., Obi F. J. Toxicol. Sci., 36, 549–557, 2011.
  • 石川裕介　　Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans. J. Toxicol. Sci., 37, 123–130, 2012.
  • 玉川明弘　　Health effects of low-level cadmium intake and the role of metallothionein on cadmium transport from mother rats to fetus. Yaginuma-Sakurai K., Murata K., Iwai-Shimada M., Nakai K., Kurokawa N., Tatsuta N., Satoh H. J. Toxicol. Sci., 37, 149–156, 2012.
  • 中尾康佑　Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygense-1. Ashino T., Sugiuchi J., Uehara J., Naito-Yamamoto Y., Kenmotsu S., Iwakura Y., Shioda S., Numazawa S., Yoshida T. J. Toxicol. Sci., 36, 635–643, 2011.
  • 西山雄一郎　　Diurnal variation of cadmium-induced mortality in mice. Miura N., Yanagiba Y., Ohtani K., Mita M., Togawa M., Hasegawa T. J. Toxicol. Sci., 37, 191–196, 2012.
  • 志賀大輝　　siRNA-mediated knockdown of the melanocortin 2 receptor accessory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK293 cells. Hwang G.W., Oh S.E., Takahashi T., Lee J.Y., Naganuma A. J. Toxicol. Sci., 35, 947–950, 2010.
  • 平手琢真　　Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells. Hwang G.W., Ryoke K., Takahashi T., Naganuma A. J. Toxicol. Sci., 35, 941–944, 2010.
  • 久野晃子　　siRNA-mediated AMPKα1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells. Hwang G.W., Tobita M., Takahashi T., Kuge S., Kita K., Naganuma A. J. Toxicol. Sci., 35, 601–604, 2010.
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平成23年度（2011年度）外書講読論文
外書講読 II
  • 渡邉久高　　Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. Chung R.S., Penkowa M., Dittmann J., King C.E., Bartlett C., Asmussen J.W., Hidalgo J., Carrasco J., Leung Y.K., Walker A.K., Fung S.J., Dunlop S.A., Fitzgerald M., Beazley L.D., Chuah M.I., Vickers J.C., West A.K. J. Biol. Chem., 283, 15349–15358, 2008.
  • 岩田紘司朗　　Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Yu X., Sidhu J.S., Hong S., Robinson J.F., Ponce R.A., Faustman E.M. Toxicol. Sci., 120, 403–412, 2011.
  • 加藤真由　　Involvement of glycogen synthase kinase-3β in arsenic trioxide-induced p21 expression. Huang H.S., Liu Z.M., Cheng Y.L. Toxicol. Sci., 121, 101–109, 2011.
  • 井上綱基　　Activation of the Nrf2 pathway, but decreased gamma-glutamylcysteine synthetase heavy subunit chain levels and caspase-3-dependent apoptosis during exposure of primary mouse hepatocytes to diphenylarsinic acid. Sumi D., Manji A., Shinkai Y., Toyama T., Kumagai Y. Toxicol. Appl. Pharmacol., 223, 218–224, 2007.
  • 小田裕樹　　Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b. Wang Z., Zhao Y., Smith E., Goodall G.J., Drew P.A., Brabletz T., Yang C. Toxicol. Sci., 121, 110–122, 2011.
  • 鈴木耕平　　The effects of cadmium on VEGF-mediated angiogenesis in HUVECs. Kim J., Lim W., Ko Y., Kwon H., Kim S., Kim O., Park G., Choi H., Kim O. J. Appl. Toxicol., 32, 342–349, 2012.
  • 服部雄太　　Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Miyazaki I., Asanuma M., Kikkawa Y., Takeshima M., Murakami S., Miyoshi K., Sogawa N., Kita T. Glia, 59, 435–451, 2011.
  • 黒田亮顕　　Early life inorganic lead exposure induces testicular teratoma and renal and urinary bladder preneoplasia in adult metallothionein-knockout mice but not in wild type mice. Tokar E.J., Diwan B.A., Waalkes M.P. Toxicology, 276, 5–10, 2010.
  • 小椋健司　　Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells. Kim H.G., Kim J.Y., Han E.H., Hwang Y.P., Choi J.H., Park B.H., Jeong H.G. FEBS Lett., 585, 421–428, 2011.

外書講読 I
  • 渡邉久高　　Differential sensitivity and responsiveness of three human cell lines HepG2, 1321N1 and HEK 293 to cadmium. Lawal A.O., Ellis E. J. Toxicol. Sci., 35, 465–478, 2010.
  • 岩田紘司朗　　Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms. Hirooka T., Fujiwara Y., Shinkai Y., Yamamoto C., Yasutake A., Satoh M., Eto K., Kaji T. J. Toxicol. Sci., 35, 287–294, 2010.
  • 加藤真由　　Neurotoxic action of inorganic mercury injected in the intraventicular space of mouse cerebrum. Yasutake A., Marumoto M., Yoshida M. J. Toxicol. Sci., 35, 767–771, 2010.
  • 井上綱基　　The enhanced elimination of tissue methylmercury in Parachlorella beijerinckii-fed mice. Uchikawa T., Kumamoto Y., Maruyama I., Kumamoto S., Ando Y., Yasutake A. J. Toxicol. Sci., 36, 121–126, 2011.
  • 小田裕樹　　Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells. Abiko Y., Shinkai Y., Sumi D., Kumagai Y. J. Toxicol. Sci., 35, 419–423, 2010.
  • 鈴木耕平　　Genetic background of resistance to cadmium-induced testicular toxicity in inbred Wister0Imamichi rats. Shimada H., Hata I., Hashiguchi T., Imamura Y. Arch. Toxicol., 85, 1195–1199, 2011
  • 服部雄太　　Basal metallothionein-I/II protects against NMDA-mediated oxidative injury in cortical neuron/astrocyte cultures. Yu X., Guo J., Fang H., Peng S. Toxicology, 282, 16–22, 2011.
  • 黒田亮顕　　Cross-resistance of cadmium-resistant cells to manganese is associated with reduced accumulation of both cadmium and manganese. Fujishiro H., Kubota K., Inoue D., Inoue A., Yanagiya T., Enomoto S., Himeno S. Toxicology, 280, 118–125, 2011.
  • 小椋健司　　Dietary zinc and metallothionein on small intestinal disaccharidase activity in mice. Tran C.D., Cool J., Xian C.J. World J. Gastroenterol., 17, 354–360, 2011.
　　　
　　　
　　　

平成22年度（2010年度）外書講読論文
外書講読 I, II
  • 石井彩香　　Mercury in soils and plants in an abandoned cinnabar mining area (SW Spain). García-Sánchez A., Murciego A., Alvarez-Ayuso E., Regina I.S., Rodríguez-González M.A. J. Hazard. Mater., 168, 1319–1324, 2009.
  • 加藤万理　　Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain. Asanuma M., Miyazaki I., Higashi Y., Tanaka K., Haque M.E., Fujita N., Ogawa N. Neurosci. Lett., 327, 61–65, 2002.
  • 加藤侑子　　Recent Heavy Metal Concentrations in Watarase Basin around Ashio Mine. Ohmichi K., Seno Y., Takahashi A., Kojima K., Miyamoto H., Ohmichi M., Matsuki Y., Machida K.. J. Health Sci., 52, 465–468, 2006.
  • 菊地雄基　　Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesufonate. Ashino T., Ozawa S., Numazawa S., Yoshida T. J. Toxicol. Sci., 28, 181–189, 2003.
  • 武川　唯　　Effects of Cadmium chloride on Neurite Outgrowth and Gene Expression in Human Neuroblastoma NB-1 Cells. Pramanik R., Ishido M., Kunimoto M. J. Health Sci., 47, 478–482, 2001.
  • 牧内哲史　　Detection of High Levels of Arsenic and Mercury in Some Chinese Traditionel Medicines Using X-Ray Fluorescence Spectrometry. Mino Y., Yamada Y.. J. Health Sci.,51, 607–613, 2005.
  • 政木寛之　　Assessment of Mercury Contamination in the Kahayan River, Central Kalimantan, Indonesia. Elvince R., Inoue T., Tsushima K., Takayanagi R., Darung A.U., Gumiri S., Dohong S., Nagafuchi O., Kawakami T., Yamada T. J. Water Environ. Technol., 6, 103–112, 2008.
  • 村瀬光弘　　Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats. Miyazaki I., Sogawa C.A., Asanuma M., Higashi Y., Tanaka K.I., Nakanishi T., Ogawa N. Neurosci. Lett., 293, 65–68, 2000.
  • 山口祐樹　　Cadmium induces expression of metallothionein in rat dental pulp. Tamura Y., Ohya K. Jpn. J. Pharmacol., 83, 632–364, 2000.
　　　　
　　　　


平成20年度（2008年度）外書講読論文
外書講読 I
  • 寺尾麻希　　Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. Shinkai Y., Sumi D., Fukami I., Ishii T., Kumagai Y. FEBS. Lett., 580, 1771–1774, 2006.
  • 北川貴大　　Induction of metallothionein synthesis by cilostazol in mice and in human cultured neuronal cell lines. Biol. Pharm. Bull., 30, 791–794, 2007.
  • 坂野博紀　　Analyses of the metallothioneins and trace metals in the liver and serum of the patients with hepatocellular carcinoma. Kawata T., Nakamura S., Nakayama A., Enomoto S., Fukuda H., Ebara M., Kubo K., Minami T., Sakurai H. Biomed. Res. Trace Elements, 15, 348–350, 2004.
  • 小室広明　　Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species. You H.J., Oh D.H., Choi C.Y., Lee D.G., Hahm K.S., Moon A.R., Jeong H.G. Biochim. Biophys. Acta, 1573, 33–38, 2002.　
  • 岡田圭子　　Expression of ZnT-1 (Slc30a1) and MT-1 (Mt1) in the conceptus of cadmium treated mice. Fernandez E.L., Dencker L., Tallkvist J. Reprod. Toxicol., 24, 353–358, 2007.　
  • 上野　愛　　Current hair mercury levels in Japanese: survey in five districts. Yasutake A., Matsumoto M., Yamaguchi M., Hachiya N. Tohoku J. Med., 199, 161–169, 2003.　
  • 伊藤亜沙子　　A phase II trial of arsenic trioxide in patients with metastatic melanoma. Kim K.B., Bedikian A.Y., Camacho L.H., Papadopoulos N.E., McCullough C. Cancer, 104, 1687–1692, 2005.　　　　　　　　　　　　

外書講読 II
  • 伊藤さやか　　Cadmium accumulation in aortas of smokers. Abu-Hayyeh S., Sian M., Jones K.G., Manuel A., Powell J.T. Arterioscler. Thromb. Vasc. Biol., 21, 863–867, 2001.
  • 寺尾麻希　　Arsenic accumulation decreased in metallothionein null cisplatin-resistant cell lines. Suzuki T., Ohata S., Togawa T., Himeno S., Tanabe S. J. Toxicol. Sci., 32, 321–328, 2007.
  • 北川貴大　　Cytochrome C release from mitochondria induced by cadmium. Kondoh M., Ogasawara S., Araragi S., Higashimoto M., Sato M. J. Health Sci., 47, 78–82, 2001.
  • 坂野博紀　　Short-interfering RNA-mediated silencing of thioredoxin reductase 1 alters the sensitivity of HeLa cells toward cadmium. Nishimoto M., Sakaue M., Hara S. Biol. Pharm. Bull., 29, 543–546, 2006.
  • 小室広明　　Changes in copper and zinc status and response to dietary copper deficiency in metallothionein-overexpressing transgenic mouse heart. Kang Y.J., Jiang Y., Saari J.T. J. Nutr. Biochem., 18, 714–718, 2007.
  • 岡田圭子　　Role of placental metallothionein in maternal to fetal transfer of cadmium in genetically altered mice. Lau J.C., Joseph M.G., Cherian M.G. Toxicology, 127, 167–178, 1998.
  • 上野　愛　　Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China. Liu J., Cheng M.L., Yang Q., Shan K.R., Shen J., Zhou Y., Zhang X., Dill A.L., Waalkes M.P. Environ. Health Perspect., 115, 1101–1106, 2007.　　
  • 伊藤亜沙子　　Placental transfer of mercury in pregnant rats which received dental amalgam restorations. Takahashi Y., Tsuruta S., Arimoto M., Tanaka H., Yoshida M. Toxicology, 185, 23–33, 2003.