外書講読 I・II


外書講読 I

  • 上村幸央 Distribution and chemical form of mercury in commercial fish tissues. J. Toxicol. Sci. 37, 853-861, 2012.
  • 溝口 遼 Participation of metal transporters in cadmium transport from mother rat to fetus. J. Toxicol. Sci. 37, 1035-1044, 2012.
  • 森 健景 Propolis suppresses CdCl₂-induced cytotoxicity of COS7 cells through the prevention of intracellular reactive oxygen species accumulation. Biol. Pharm. Bull. 35, 1126-1131, 2012.
  • 成木万理子 Influence of injection timing on severity of cadmium-induced testicular toxicity in mice. J. Toxicol. Sci. 38, 145-150, 2013.
  • 宮脇 希 Involvement of the essential metal transporter Zip14 in hepatic Cd accumulation during inflammation. Toxicol. Lett., 218, 91-96, 2013.
  • 古川洋光 The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of Aβ(1-42) with Cu ions. J. Biol. Inorg. Chem. 18, 39-47, 2013.
  • 喜畑敬介 Role of Arf1 in endosomal trafficking of protein-metal complexes and cadmium-metallothionein-1 toxicity in kidney proximal tubule cells. Toxicol. Lett., 203, 210-218, 2013.
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外書講読 II
  • 井内文哉 Renal function after reduction in cadmium exposure: an 8‐year follow‐up of residents in cadmium‐polluted areas. Environ. Health Perspect., 120, 223-228, 2012.
  • 石川裕介 Activation of HIF-1 by metallothionein contributes to cardiac protection in the diabetic heart. Am. J. Physiol. Heart Circ. Physiol., 302, H2528-2535, 2012.
  • 玉川明弘 Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol. Appl. Pharmacol., 263, 14-20, 2012.
  • 中尾康佑 Cadmium induces p53-dependent apoptosis in human prostate epithelial cells. PLoS ONE, 7, e33647, 2012.
  • 西山雄一郎 Role of zinc metallothionein-3 (ZnMt3) in epidermal growth factor (EGF)-induced c-Abl protein activation and actin polymerization in cultured astrocytes. J. Biol. Chem., 286, 40847-40856, 2011.
  • 志賀大輝 Cross-resistance of cadmium-resistant cells to manganese is associated with reduced accumulation of both cadmium and manganese. Toxicology, 280, 118-125, 2011.
  • 久野晃子 Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo. Toxicol. Lett., 212, 91-96, 2012.
  • 平手琢真 Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. Metallomics, 4, 700-708, 2012.

外書講読 I
  • 井内文哉 Antioxidant effects of heated garlic juice on cadmium-induced liver damage in rats as compared to ascorbic acid. J Toxicol Sci. 2011 Oct;36(5):549-57.
  • 石川裕介 Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans. J Toxicol Sci. 2012 Feb;37(1):123-30.
  • 玉川明弘 Health effects of low-level cadmium intake and the role of metallothionein on cadmium transport from mother rats to fetus. J Toxicol Sci. 2012 Feb;37(1):149-56.
  • 中尾康佑 Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygense-1. J Toxicol Sci. 2011 Oct;36(5):635-43.
  • 西山雄一郎 Diurnal variation of cadmium-induced mortality in mice. J Toxicol Sci. 2012 Feb;37(1):191-6.
  • 志賀大輝 siRNA-mediated knockdown of the melanocortin 2 receptor accessory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK293 cells. J Toxicol Sci. 2010 Dec;35(6):947-50.
  • 平手琢真 Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells. J Toxicol Sci. 2010 Dec;35(6):941-4.
  • 久野晃子 siRNA-mediated AMPKα1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells. J Toxicol Sci. 2010 Aug;35(4):601-4.
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外書講読 II
  • 渡邉久高 Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. J. Biol. Chem., 283, 15349-15358, 2008.
  • 岩田紘司朗 Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicol. Sci., 120, 403-412, 2011.
  • 加藤真由 Involvement of glycogen synthase kinase-3β in arsenic trioxide-induced p21 expression. Toxicol. Sci., 121, 101-109, 2011.
  • 井上綱基 Activation of the Nrf2 pathway, but decreased gamma-glutamylcysteine synthetase heavy subunit chain levels and caspase-3-dependent apoptosis during exposure of primary mouse hepatocytes to diphenylarsinic acid. Toxicol. Appl. Pharmacol., 223, 218-224, 2007.
  • 小田裕樹 Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b. Toxicol. Sci., 121, 110-122, 2011.
  • 鈴木耕平 The effects of cadmium on VEGF-mediated angiogenesis in HUVECs. J. Appl. Toxicol., 32, 342-349, 2012.
  • 服部雄太 Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia, 59, 435-451, 2011.
  • 黒田亮顕 Early life inorganic lead exposure induces testicular teratoma and renal and urinary bladder preneoplasia in adult metallothionein-knockout mice but not in wild type mice. Toxicology, 276, 5-10, 2010.
  • 小椋健司 Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells. FEBS Lett., 585, 421-428, 2011.
外書講読 I
  • 渡邉久高 Differential sensitivity and responsiveness of three human cell lines HepG2, 1321N1 and HEK 293 to cadmium. J. Toxicol. Sci., 35, 465-478, 2010.
  • 岩田紘司朗 Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms. J. Toxicol. Sci., 35, 287-294, 2010.
  • 加藤真由 Neurotoxic action of inorganic mercury injected in the intraventicular space of mouse cerebrum. J. Toxicol. Sci., 35, 767-771, 2010.
  • 井上綱基 The enhanced elimination of tissue methylmercury in Parachlorella beijerinckii-fed mice. J. Toxicol. Sci., 36, 121-126, 2011.
  • 小田裕樹 Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells. J. Toxicol. Sci., 35, 419-423, 2010.
  • 鈴木耕平 Genetic background of resistance to cadmium-induced testicular toxicity in inbred Wister0Imamichi rats. Arch. Toxicol., Published online: 2011.
  • 服部雄太 Basal metallothionein-I/II protects against NMDA-mediated oxidative injury in cortical neuron/astrocyte cultures. Toxicology, 282, 16-22, 2011.
  • 黒田亮顕 Cross-resistance of cadmium-resistant cells to manganese is associated with reduced accumulation of both cadmium and manganese. Toxicology, 280, 118-125, 2011.
  • 小椋健司 Dietary zinc and metallothionein on small intestinal disaccharidase activity in mice. World J. Gastroenterol., 17, 354-360, 2011.


外書講読 I, II
  • 石井彩香 Mercury in soils and plants in an abandoned cinnabar mining area (SW Spain). J. Hazard. Mater., 168, 1319–1324 (2009).
  • 加藤万理 Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain. Neurosci. Lett., 327, 61–65 (2002).
  • 加藤侑子 Recent Heavy Metal Concentrations in Watarase Basin around Ashio Mine. J. Health Sci., 52, 465-468 (2006).
  • 菊地雄基 Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesufonate. J. Toxicol. Sci., 28, 181-189 (2003).
  • 武川 唯 Effects of Cadmium chloride on Neurite Outgrowth and Gene Expression in Human Neuroblastoma NB-1 Cells. J. Health Sci., 47, 478-482 (2001)
  • 牧内哲史 Detection of High Levels of Arsenic and Mercury in Some Chinese Traditionel Medicines Using X-Ray Fluorescence Spectrometry. J. Health Sci., 51, 607-613 (2005).
  • 政木寛之 Assessment of Mercury Contamination in the Kahayan River, Central Kalimantan, Indonesia. J. Water Environ. Technol., 6, 103-112 (2008).
  • 村瀬光弘 Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats. Neurosci. Lett., 293, 65-68 (2000).
  • 山口祐樹 Cadmium induces expression of metallothionein in rat dental pulp. Jpn. J. Pharmacol., 83, 632-364 (2000).

外書講読 I
  • 寺尾麻希Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. FEBS Letters, 580, 1771-1774 (2006)
  • 北川貴大Induction of metallothionein synthesis by cilostazol in mice and in human cultured neuronal cell lines. Biol. Pharm. Bull., 30, 791-794 (2007)
  • 坂野博紀Analyses of the metallothioneins and trace metals in the liver and serum of the patients with hepatocellular carcinoma. Biomed. Res. Trace Elements, 15, 348-350 (2004)
  • 小室広明Protective effect of metallothionein-III on DNA damage in response to reactive oxygen species. Biochim. Biophys. Acta, 1573, 33-38 (2002) 
  • 岡田圭子Expression of ZnT-1 (Slc30a1) and MT-1 (Mt1) in the conceptus of cadmium treated mice. Reprod. Toxicol., 24, 353-358 (2007) 
  • 上野@@Current hair mercury levels in Japanese: survey in five districts. Tohoku J. Med., 199, 161-169 (2003) 
  • 伊藤亜沙子A phase II trial of arsenic trioxide in patients with metastatic melanoma. Cancer, 104, 1687-1692 (2005)            
外書講読 II
  • 伊藤さやかCadmium accumulation in aortas of smokers arteriosclerosis, Arterioscler. Thromb. Vasc. Biol., 21, 863-867 (2001)
  • 寺尾麻希Arsenic accumulation decreased in metallothionein null cisplatin-resistant cell lines. J. Toxicol. Sci., 32, 321-328 (2007)
  • 北川貴大Cytochrome C release from mitochondria induced by cadmium. J. Health Sci., 47, 78-82 (2001)
  • 坂野博紀Short-interfering RNA-mediated silencing of thioredoxin reductase 1 alters the sensitivity of HeLa cells toward cadmium. Biol. Pharm. Bull., 29, 543-546 (2006)
  • 小室広明Changes in copper and zinc status and response to dietary copper deficiency in metallothionein-overexpressing transgenic mouse heart. J. Nutr. Biochem., 18, 714-718 (2007)
  • 岡田圭子Role of placental metallothionein in maternal to fetal transfer of cadmium in genetically altered mice. Toxicology, 127, 167-178 (1998)
  • 上野@@Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China. Environ. Health Perspect., 115, 1101-1106 (2007)  
  • 伊藤亜沙子Placental transfer of mercury in pregnant rats which received dental amalgam restorations. Toxicology, 185, 23-33 (2003)