業績 (2006年以降の論文を掲載しています)

(2016年 1月〜)

著書
  1. 小川法子, 山本浩充, 医薬品添加剤の処方設計と物性評価, 監修:寺田勝英 発行:シーエムシー出版 第3編 分析・物性評価 
  2. 小川法子, 山本浩充, 難水溶性薬物の経口製剤化技術最前線, 監修:川上亘作, 発行:シーエムシー出版, 第3章 非晶質固体分散体 5.シクロデキストリンを利用した固体分散体設計

原著
  1. Takahashi C., Akachi Y., Ogawa N., Moriguchi K., Asaka T., Tanemura M., Kawashima Y.,Yamamoto H., Morphological study of efficacy of clarithromycin-loaded nanocarriers for treatment of biofilm infection disease. Medical Molecular Morphology, accepted (2016)
  2. Takahashi, C., Muto, S., Yamamoto, H., A microscopy observation methodology for STEM imaging of antibacterial activity of polymeric nanoparticles on biofilm with an ionic liquid., J. Biomed. Mater. Res. B. (2016)
  3. Ogawa N., Furuishi T., Nagase H., Endo T., Takahashi C., Yamamoto H., Kawashima Y., Loftsson T., Kobayashi M., Ueda H., Interaction of fentanyl with various cyclodextrins in aqueous solutions. J Pharm Pharmacol, 68, 588-597 (2016)
総説・解説
  1. 小川法子, 解説フロンティア研究シリーズ シクロデキストリンとの相互作用評価に基づく難溶性薬物の製剤化, 粉体工学会誌, 53, 1, 21-26 (2016)


(2015年 1月〜12月)

原著
  1. Takahashi C., Kalita G., Ogawa N., Moriguchi K., Tanemura M., Kawashima Y., Yamamoto H., Electron microscopy of Staphylococcus epidermidis fibril and biofilm formation using image enhancing ionic liquid. Anal Bioanal Chem, 407, pp1607-1613 (2015)
  2. Ogawa N., Hashimoto T., Furuishi T., Nagase H., Endo T., Yamamoto H., Kawashima Y., Ueda H., Solid-state characterization of sertraline base-β-cyclodextrin inclusion complex.J Pharm Biomed Anal 107 (25) pp265-272 (2015)
  3. Takahashi C., Ogawa N., Kawashima Y., Yamamoto H., Observation of antibacterial effect of biodegradable polymeric nanoparticles on Staphylococcus epidermidis biofim using FE-SEM with an ionic liquid. Microscopy, 64, pp169-180 (2015)
  4. Nagane K., Kimura S., Ukai K., Takahashi C., Ogawa N., Yamamoto H., Application of spherical silicate to prepare solid dispersion dosage forms with aqueous polymers. Int J Pharm, 493, pp55-62 (2015)
  5. 山本浩充、小林万里、芳賀吏那子、伊東奈保美、小川法子、田口真穂、高橋知里、磯部隆史、埴岡伸光、村田実希郎、岡田賢二、重山昌人, がん切除手術に用いられるMohsペーストに関する製剤学的研究. 薬剤学, 75, 4, pp264-270 (2015)
  6. Takahashi C., Saito S., Suda A., Ogawa N., Kawashima Y., Yamamoto H., Antibacterial activities of polymeric poly (DL-lactide-co-glycolide) nanoparticles and Soluplus micelles against Staphylococcus epidermidis biofilm and their characterization. RSC Advances, 5, pp71709-71717 (2015)
  7. Ikuta N., Endo T.,Hosomi S.,Setou K., Tanaka S., Ogawa N., Yamamoto H., Mizukami M., Arai S., Okuno M., Takahashi K., Terao K.,Matsugo S., Structural analysis of crystalline R(+)-alpha-lipoic acid-alpha-cyclodextrin complex based on microscopic and spectroscopic studies, Int J Mol Sci 16, 24614-24628 (2015)
  8. Yaakob Y., Mohd Yusop M.Z., Takahashi C., Rosmi M.S., Kalita G., Tanemura M., In situ transmission electron microscopy of Ag-incorporated carbon nanofibers: The effect of Ag nanoparticle size on graphene formation., RSC Adv. (2015)
  9. Takahashi C., Yamamoto H., Fuji M., Electron microscopy observation of hydrous materials using a hydrophilic ionic liquid; 1-butyl-3-methylimidazolium tetrafluoroborate. J. Electr. Microsc. Technol. Med. Biol. (2015)
  10. Vineesh T.V., Praveen K.M., Takahashi C., Kalita G., Alwarappan S., Pattanayak D.K., Narayanan T.N.. Bifunctional electrocatalytic activities of boron doped graphene derived from boron carbide. Adv. Eng. Mater. (2015)
総説・解説
  1. Yamamoto H., Ogawa N., Takahashi C., Design of nanoparticulate drug delivery system for biofilm infection disease by spherical crystallization method. Drug. Deliv. Sys. 30, 129-138 (2015)
  2. Ogawa N.,Takahashi C.,Yamamoto H., Physicochemical characterization of cyclodextrin-drug interactions in the solid state and the effect of water on these Interactions. J Pharm Sci 104, pp942-954 (2015)

(2014年 1月〜12月)

著書
  1. 山本浩充, 小川法子, 薬剤学実験必携マニュアル, 株式会社南江堂 (2014)
  2. 山本浩充, コンパス 物理化学 第二版, 株式会社南江堂 (2014)

原著
  1. Nagane K, Kimura S, Ukai K, Ogawa N, Yamamoto H, Practical approach to prepare solid dispersion drug product using spherical silicate, Int J Pharm, 485, 364-371 (2014)
  2. Obata T, Suzuki Y, Ogawa N, Kurimoto I, Yamamoto H, Furuno H, Sasaki T, Tanaka M, Improvement of the antitumor activity of poorly soluble sapacitabine (CS-682) by using SoluplusR as a surfactant, Biol Pharm Bull 37, 802-807 (2014)
  3. Ikuta K, Tanaka A, Otsubo A, Ogawa N, Yamamoto H, Mizukami T, Arai S, Okuno M, Terao K, Matsugo S, Spectroscopic studies of R(+)-alpha-lipoic acid?cyclodextrin complexes, Int J Mol Sci, 15, 20469-20485 (2014)
  4. Takahashi, C. Pattanayak, K.D. Shirai, T. Fuji, M. Solvent effect on observation of nanostructural hydrated porous ceramic green bodies using hydrophilic ionic liquid, RSC adv., 4, 27322, 2014.
  5. Takahashi, C. Shirai, T. Fuji, M.Selective intercalation of ionic liquid in montmorillonite and influence of water molecules, Solid. State. Ionics, 267, 16-21, 2014.
  6. Takahashi,C. Yaakob, Y. Yusop,M.Z. Kalita,G. Tanemura, M. Direct observation of structural change in Au-incorporated carbon nanofibers during field emission process, Carbon, 75, 277-280, 2014.
  7. Mohd Rosmi,S. Mohd Yusop, M.Z. Kalita, G. Yaakob, Y. Takahashi, C. Tanemura, M. Visualizing copper assisted graphene growth in nanoscale. Scientific reports, 4, 7563, 2014.
  8. Yusop,M.Z. Kalita,G. Yaakob, Y. Takahashi,C. Tanemura, M. Field emission properties of chemical vapor deposited individual graphene, Appl Phys Lett, 104, 093501, 2014.
  9. Suzuki, T. Sobukawa, A. Takahashi, C. Yoshida, R. Kato, T. Sasaki, K. Yamamoto, T. Development of in situ transmission electron microscopy of the anode reaction in the lithium-ion battery, AMTC. Lett, 274-275, 2014.
総説・解説
  1. 山本浩充:日本薬剤学会第39回製剤・創剤セミナー報告, 薬剤学, 74(6), 1-3 (2014)
  2. 山本浩充:学会報告グラビア 第39回製剤・創剤セミナー報告, 薬剤学, 74(6), 巻頭 (2014)
  3. 高橋知里:学会報告グラビア 第5回アジアアーデンカンファレンス, 薬剤学, 74, 巻頭 (2014)
  4. 高橋知里:学位論文紹介 イオン液体を用いた含水試料の電子顕微鏡観察手法の開発とその応用, 粉体工学会誌, 51, pp 541 (2014)
  5. 高橋知里:学会報告 International Microscopy Conference 18, 顕微鏡, 49, pp 233 (2014)

(2013年 1月〜12月)
著書
  1. 山本浩充,非経口投与製剤の開発と応用−次世代型医薬品の新規投与形態の開拓を目指して−,シーエムシー出版 (2013)
  2. 山本浩充,粉・粒体の構造制御、表面処理とプロセス設計、情報技術協会 (2013)
  3. 山本浩充、川島嘉明、塚田雄亮、辻本広行、三羽信比古, ポリマーフロンティア21講演録シリーズ 35 微粒子材料 〜未来を拓く機能材料〜, NTS (2013)
  4. 塚田雄亮、辻本広行、山本浩充、川島嘉明、DDS製剤の開発・評価と実用化手法,技術情報協会 (2013))

原著
  1. Ogawa N, Kaga M, Endo T, Nagase H, Furuishi T, Yamamoto H, Kawashima Y, Ueda H., Quetiapine free base complexed with cyclodextrins to improve solubility for parenteral use., Chem Pharm Bull, 61, 809-815 (2013)
  2. Nagahara A, Mitani A, Fukuda M, Yamamoto H, Tahara K, Morita I, Ting CC, Watanabe T, Fujimura T, Osawa K, Sato S, Takahashi S, Iwamura Y, Kuroyanagi T, Kawashima Y, Noguchi T., Antimicrobial photodynamic therapy using a diode laser with a potential new photosensitizer, indocyanine green-loaded nanospheres, may be effective for the clearance of Porphyromonas gingivalis., J Periodontal Res., 48, 591-599 (2013)
  3. Takahashi C, Shirai T, Fuji M., Electron microscopic observation f montmorillonite swelled by water with the aid of hydrophilic ionic liquid, Mater Chem Phys., 141, 657-664 (2013).
  4. Takahashi C, Shirai T, Hayashi Y, Fuji M., Study of intercalation compounds using ionic liquids into montmorillonite and their thermal stability., Solid State Ionics., 241, 53?61 (2013).
  5. Takahashi C, Pattanayak D, Shirai T, Fuji M., A simple approach to observe non-conductive hydrated materials with FE-SEM: Case study on porous hydroxyapatite green bodies., Euro Ceram Soci., 33, 629?635 (2013).
  6. Kashid RV, Yusop MZ, Takahashi C, Kalita G, Panchakarla LS, Joag DS, More MA, Tanemura M., Field emission characteristics of pristine and N-doped graphene measured by in-situ transmission electron microscopy., J Appl Phys., 113, 214311 (2013).
  7. Yaakob Y, Yusop MZ, Takahashi C, Kalita G, Ghosh P, Tanemura M., Room-temperature fabrication of Au- and Ag-incorporated carbon nanofibers by ion irradiation and their field emission properties., Jpn J Appl Phys., 52, 11NL01 (2013).
  8. 高井 千加, 藤 正督, 高橋 知里, 白井 孝, 冨岡 達也, 宇津野 光朗, 球状カルサイト中空粒子の合成とその形態安定性, 粉体工学会誌, 50巻, 9号, 618-624 (2013).
総説・解説
  1. 塚田雄亮、笹井愛子、辻本広行、山本浩充、川島嘉明、三羽信比古: PLGAナノスフェアの化粧品への応用,Cosmetic Stage, 7, pp42-50 (2013).
  2. 笹井愛子、松ア香織、辻本広行、山本浩充、川島嘉明、三羽信比古: PLGAナノ粒子によるDDS技術の育毛剤への応用,Fragrance Jounal, 2013-11, pp49-55 (2013)
  3. 山本浩充:明日にかける 愛知学院大学 製剤学講座,製剤機械技術学会誌, 22 (2013)
  4. 山本浩充:基礎研究と臨床との橋渡し―ヒトに優しい製剤開発を目指して―,薬剤学 73, pp281-284 (2013)
  5. 小川法子:学会報告グラビアAAPS2012, 薬剤学, 73, 巻頭 (2013)
  6. 小川法子:学会報告Agglos10, Drug Delivery System, 28, pp466-468 (2013)
  7. Takahashi C., Shirai T., Fuji M.: Application of ionic liquids on microscopic observation of hydrated materials, Annual report Advanced Ceramics Research Center Nagoya Institute of Technology., 1, 45-52 (2013).

(2012年 1月〜12月)

著書
  1. 山本浩充, 川島嘉明 最新製剤学, 廣川書店 (2012)

原著

  1. Sugihara H, Yamamoto H, Kawashima Y, Takeuchi H., Effects of food intake on the mucoadhesive and gastroretentive properties of submicron-sized chitosan-coated liposomes., Chem Pharm Bull 60, 1320-1323 (2012)
  2. Yang M, Yamamoto H, Kurashima H, Takeuchi H, Yokoyama T, Tsujimoto H, Kawashima Y., Design and evaluation of inhalable chitosan-modified poly (DL-lactic-co-glycolic acid) nanocomposite particles., Eur J Pharm Sci. 47, 235-243 (2012)
  3. Yang M, Yamamoto H, Kurashima H, Takeuchi H, Yokoyama T, Tsujimoto H, Kawashima Y., Design and evaluation of poly(DL-lactic-co-glycolic acid) nanocomposite particles containing salmon calcitonin for inhalation., Eur J Pharm Sci., 46, 374-480 (2012)
  4. Sugihara H, Yamamoto H, Kawashima Y, Takeuchi H., Effectiveness of submicronized chitosan-coated liposomes in oral absorption of indomethacin., J Liposome Res., 22, 72-79 (2012)
  5. Yamamoto H, Tahara K, Kawashima Y., Nanomedical system for nucleic acid drugs created with the biodegradable nanoparticle platform., J Microencapsul. 29, 54-62, (2012)
  6. Tahara K, Tadokoro S, Yamamoto H, Kawashima Y, Hirashima N., The suppression of IgE-mediated histamine release from mast cells following exocytic exclusion of biodegradable polymeric nanoparticles., Biomaterials., 33, 343-351 (2012)

総説・解説
  1. 小川法子: 難水溶性薬物の製剤化に関わる研究−鼻腔投与製剤とシクロデキストリン化学そして固体分散体− 薬剤学72(6), pp339-343 (2012).

(2011年 1月〜12月)

著書
  1. 山本浩充, 川島嘉明 最新製剤学, 廣川書店 (2011)

原著
  1. Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y., Improvements in transfection efficiency with chitosan modified poly(DL-lactide-co-glycolide) nanospheres prepared by the emulsion solvent diffusion method, for gene delivery., Chem Pharm Bull, 59, pp298-301 (2011)
  2. Tahara K, Kato Y, Yamamoto H, Kreuter J, Kawashima Y., Intracellular drug delivery using polysorbate 80-modified poly(D,L-lactide-co-glycolide) nanospheres to glioblastoma cells., J Microencapsul., 28, pp29-36 (2011).
  3. Tahara K, Miyazaki Y, Kawashima Y, Kreuter J, Yamamoto H., Brain targeting with surface-modified poly(D,L-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration., Eur J Pharm Biopharm., 77, pp84-88 (2011).
  4. Tahara K, Samura S, Tsuji K, Yamamoto H, Tsukada Y, Bando Y, Tsujimoto H, Morishita R, Kawashima Y., Oral nuclear factor-κB decoy oligonucleotides delivery system with chitosan modified poly(D,L-lactide-co-glycolide) nanospheres for inflammatory bowel disease., Biomaterials., 32, 870-878 (2011).
  5. 田原耕平、山本浩充、川島嘉明, 薬物送達用生分解性ナノ粒子の表面特性が細胞との相互作用に及ぼす影響, 粉体工学会誌 48, pp173-179 (2011).
  6. Yasuji T, Takeuchi H, Kawashima Y., Particle design of poorly water-soluble drug substances using supercritical fluid technologies. Adv Drug Deliv Rev.60 388-398 (2008)
総説・解説
  1. 山本浩充, 粒子表面特性制御によるナノ粒子薬物送達システムの設計, Pharm Tech Japan, 27, pp1123-1129 (2011)

(2010年 1月〜12月)

著書
  1. 山本浩充:「難水溶性薬物の物性評価と製剤設計の新展開」(シーエムシー出版)pp 134-140 (2010年1月)

原著
  1. K. Tahara, H. Yamamoto, N. Hirashima, Y. Kawashima, Chitosan-modified poly(D,L-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects, Eur. J. Pharm. BioPharm., 74, pp421-426 (2010)
  2. S. Sun, N. Liang, H. Piao, H. Yamamoto, Y. Kawashima, F. Cui, Insulin-S.O (sodium oleate) complex-loaded PLGA nanoparticles: formulation, characterization and in vivo evaluation, J. Microencapsul., 27, pp471-478 (2010)
  3. K. Tahara, H. Yamamoto, Y. Kawashima, Cellular uptake mechanisms and intracellular distributions of polysorbate 80-modified poly (D,L-lactide-co-glycolide) nanospheres for gene delivery, Eur. J. Pharm. BioPharm., 75, pp218-224 (2010)
  4. D. Li, H. Yamamoto, H. Takeuchi, Y. Kawashima, A novel method for modifying AFM probe to investigate the interaction between biomaterial polymers (chitosan-coated PLGA) and mucin film, Eur. J. Pharm. BioPharm., 75, pp277-283 (2010)
  5. K. Tahara, S. Furukawa, H. Yamamoto, Y. Kawashima, Hybrid-modified poly(D,L-lactide-co-glycolide) nanospheres for a novel cellular drug delivery system, Int. J. Pharm., 392, pp311-313 (2010)
  6. Tahara, K., Y. Kato, H. Yamamoto, J. Kreuter, Intracellular drug delivery using polysorbate 80-modified poly(D,L-lactide-co-glycolide) nanospheres to glioblastoma cells, J. Microencapsul., 28, pp29-36 (2010)
総説・解説
  1. 山本浩充, 噴霧乾燥法による医薬品製剤粒子の設計, エアロゾル研究, 25, pp149-154 (2010)



(2009年1月〜12月)

原著

  1. Shi K, Cui F, Yamamoto H, Kawashima Y: Optimized formulation of high-payload PLGA nanoparticles containing insulin-lauryl sulfate complex., Drug Dev Ind Pharm., 35, 177-84 (2009).
  2. Tahara K, Yamamoto H, Hirashima N, Kawashima Y.: Chitosan-modified poly(d,l-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects., Eur J Pharm Biopharm. (2009).
  3. Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y. : Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.,Int J Pharm., 382, 198-204 (2009).


(2008年 1月〜12月)

著書
  1. 田原 耕平、山本 浩充、川島 嘉明:DDSのコンセプトを利用した患者指向性製剤の開発 特集「デリバリー技術の最先端」「化学工業」(化学工業社) VOL.59 No.4 64-69 (2008)
  2. 山本浩充:「ナノメディシン」(オーム社)(2008)

原著
  1. Tahara K, Sakai T, Yamamoto H, Takeuchi H, Kawashima Y., Establishing chitosan coated PLGA nanosphere platform loaded with wide variety of nucleic acid by complexation with cationic compound for gene delivery. Int J Pharm. 354, 210-216 (2008)
  2. Kimura S, Egashira K, Nakano K, Iwata E, Miyagawa M, Tsujimoto H, Hara K, Kawashima Y, Tominaga R, Sunagawa K., Local delivery of imatinib mesylate (STI571)-incorporated nanoparticle ex vivo suppresses vein graft neointima formation. Circulation. 118 S65-70 (2008)
  3. Higo S, Takeuchi H, Yamamoto H, Hino T, Kawashima Y., Slow release of tetracycline from a mucoadhesive complex with sucralfate for eradication of Helicobacter pylori. Chem Pharm Bull 56 1412-1416 (2008)
  4. Nakano K, Tozuka Y, Yamamoto H, Kawashima Y, Takeuchi H., A novel method for measuring rigidity of submicron-size liposomes with atomic force microscopy. Int J Pharm. 355 203-209 (2008)
  5. Hara K, Tsujimoto H, Tsukada Y, Huang CC, Kawashima Y, Tsutsumi M., Histological examination of PLGA nanospheres for intratracheal drug administration. Int J Pharm. 356 267-273 (2008)
  6. Yasuji T, Takeuchi H, Kawashima Y., Particle design of poorly water-soluble drug substances using supercritical fluid technologies. Adv Drug Deliv Rev.60 388-398 (2008)
  7. Kawashima Y, York P., Drug delivery applications of supercritical fluid technology. Adv Drug Deliv Rev. 60 297-298 (2008)
  8. Shi K, Cui F, Yamamoto H, Kawashima Y., Investigation of drug loading and in vitro release mechanisms of insulin-lauryl sulfate complex loaded PLGA nanoparticles. Pharmazie. 63 866-871 (2008)
  9. Shi K, Cui F, Yamamoto H, Kawashima Y., Optimized preparation of insulin-lauryl sulfate complex loaded poly (lactide-co-glycolide) nanoparticles using response surface methodology. Pharmazie. 63 721-725 (2008)


(2007年 1月〜12月)

著書
  1. 田原耕平、山本浩充、川島嘉明,遺伝子医学MOOK 別冊 絵で見てわかるナノDDS―マテリアルから見た治療・診断・予後・予防、ヘルスケア技術の最先端― 編 集:田畑泰彦,株式会社メディカルドゥ 70-75 (2007)
  2. H.Yamamoto,Nanoparticle Technology Handbook 監修:M. Hosokawa  Elsevier 543-546 (2007)


原著
  1. M. Yang, S. Velaga, H. Yamamoto, H. Takeuchi, Y. Kawashima, L. Hovgaard, van de M. Weert, S. Frokjaer, Characterisation of salmon calcitonin in spray-dried powder for inhalation. Effect of chitosan. Int J Pharm. 331, 176-181 (2007)
  2. Hiromitsu Yamamoto, Wataru Hoshina, Homare Kurashima, Hirofumi Takeuchi, Yoshiaki Kawashima, Toyokazu Yokoyama, Hiroyuki Tsujimoto, Engineering of poly(DL-lactic-co-glycolic acid) nanocomposite particles for dry powder inhalation dosage forms of insulin with the spray-fluidized bed granulating system. Adv. Powder Techonol., 18, 215-228 (2007)
  3. 山本浩充、田原耕平、川島嘉明, 球形晶析法を利用したナノ粒子システムによるシクロスポリンの溶解性改善と経口固形製剤設計. 今日の移植, 20, 569-571 (2007)


(2006年1月〜12月)

総説
  1. 川島嘉明; PLGA微粒子を利用したインスリンデリバリー, 日本臨床, 64(2), 301-307, (2006)
  2. 川島嘉明; コンポジット化ナノ粒子の製剤機能, ケミカルエンジニヤリング, 51(3), 37-45, (2006)
  3. 川島嘉明; PLGAナノスフェアの設計とDDSへの展開, 薬剤学, 66(4), 224-238, (2006)


原著
  1. Hara K, Tsujimoto H, Huang CC, Kawashima Y, Mimura H, Miwa N.; The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration., Oncol Rep., 16(6), 1215-1220(2006)
  2. Cui F, Shi K, Zhang L, Tao A, Kawashima Y.; Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: preparation, in vitro characterization and in vivo evaluation., J Control Release., 114(2), 242-50(2006)
  3. Thongborisute J, Takeuchi H, Yamamoto H, Kawashima Y.; Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine., J Liposome Res. (2), 127-41(2006)
  4. Thongborisute J, Takeuchi H, Yamamoto H, Kawashima Y.; Properties of liposomes coated with hydrophobically modified chitosan in oral liposomal drug delivery., Pharmazie., 61(2), 106-11(2006)
  5. Ambruosi A, Khalansky AS, Yamamoto H, Gelperina SE, Begley DJ, Kreuter J., Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats., J Drug Target., 14(2), 97-105(2006),
  6. 谷村信爾、川添博義、山本浩充、竹内洋文; 噴霧乾燥HPC-Lを結合剤として用いた低成形性医薬品粉末の直接打錠, 粉体工学会誌, 43(9), 28-32(2006)