業績(論文・書籍等)


原著

Bioorg. Med. Chem., inpress.

Ken-ichi Nakashima, Takumi Ogiwara, Takao Hirai, Toshiyuki Tanaka, Hiroko Murata, Kouichi Kaburagi, Yoshiaki Fujii-Kuriyama, Hidetoshi Hayashi, Makoto Inoue. Geronthoxanthone B from Maclura cochinchinensis var. gerontogea exhibits anti-inflammatory potential as an aryl hydrocarbon receptor agonist.


Tetrahedron Lett., 58, 2248–2251 (2017).

Ken-ichi Nakashima, Junko Tomida, Takao hirai, Yuji Morita, Yoshiaki Kawamura, Makoto Inoue. Tubakialactones A–E, new polyketides from the endophytic fungus Tubakia sp. ECN-111.


Heterocycles, 94, 308–313 (2017).

Ken-ichi Nakashima, Junko Tomida, Masanori Tabata, Takao hirai, Yuji Morita, Yoshiaki Kawamura, Makoto Inoue. A new chromone derivative from an endophytic fungus Xylaria sp. isolated from Ardisia crenata.


Heterocycles, 94, 117–121 (2017).

Ken-ichi Nakashima, Junko Tomida, Takao hirai, Yuji Morita, Yoshiaki Kawamura, Makoto Inoue. A new isocoumarin derivative from an endophytic fungus Thielavia sp. isolated from Crassula ovata.


J. Nat. Med., 71, 299–304 (2017).

Ken-ichi Nakashima, Naohito Abe, Fang-Rong Chang, Makoto Inoue, Masayoshi Oyama. Pteleifoliols A–E, acetophenone di-C-glycosides and a benzopyran dimer from the leaves of Melicope pteleifolia.


J. Nat. Med., 70, 476–482 (2016).

Ken-ichi Nakashima, Hiroki Tanabe, Yoshiaki Fujii-Kuriyama, Hidetoshi Hayashi, Makoto Inoue. Atranorin and lecanoric acid antagonize TCDD-induced xenobiotic response element-driven activity, but not xenobiotic response element-independent activity.


Front. Microbiol., 7, 1223 (2016).

Yuji Morita, Ken-ichi Nakashima, Kunihiko Nishino, Junko Tomida, Makoto Inoue, Yoshiaki Kawamura. Berberine is a novel type efflux inhibitor which attenuates the MexXY-mediated aminoglycoside resistance in Pseudomonas aeruginosa.


Fitoterapia, 111, 154–159 (2016).

Ken-ichi Nakashima, Naohito Abe, Masayoshi Oyama, Makoto Inoue. Yuccalides A–C, three new phenolic compounds with spiro-structures from the roots of Yucca gloriosa.


Bioorg. Med. Chem. Lett., 25, 1998-2001 (2015).

Ken-ichi Nakashima, Toshiyuki Tanaka, Hiroko Murata, Kouichi Kaburagi, Makoto Inoue. Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity.


J. Nat. Prod., 77, 1670-1677 (2014).

Makoto Inoue, Hiroki Tanabe, Ken-ichi Nakashima, Yukihiro Ishida, Hitoshi Kotani. Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.


Biochim. Biophys. Acta, 1840, 3034-3041 (2014).

Ken-ichi Nakashima, Tohru Murakami, Hiroki Tanabe, and Makoto Inoue. Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis.


Bioorg. Med. Chem., 22, 3204-3212 (2014).

Hiroki Tanabe, Tomohiro Yasui, Hitoshi Kotani, Akito Nagatsu, Makoto Makishima, Sakae Amagaya, Makoto Inoue. Retinoic acid receptor agonist activity of naturally occurring diterpenes.


Biochem. Pharmacol., 86, 1731-1738 (2013).

Yoshikazu Inoh, Satoshi Tadokoro, Hiroki Tanabe, Makoto Inoue, Naohide Hirashima, Mamoru Nakanishi, Tadahide Furuno. Inhibitory effects of a cationic liposome on allergic reaction mediated by mast cell activation.


Phytochem. Lett., 6, 215-218 (2013).

Masayoshi Oyama, Ken-ichi Nakashima, Tetsuro Kamiya, Manami Haba, Tetsuro Ito, Hiroko Murata, Toshiyuki Tanaka, Tetsuo Adachi, Munekazu Iinuma, Takeshi Kinoshita. Flavonoids isolated from the leaves of Melicope triphylla and their extracellularsuperoxide dismutase-inducing activity.


Biochem. Pharmacol., 84, 692-700 (2012).

Makoto Inoue, Hiroki Tanabe, Akira Matsumoto, Michiyo Takagi, Keizo Umegaki, Sakae Amagaya, Jiro Takahashi. Astaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipicytes and macrophages.


Chem. Biodiv., 9, 2195-2202 (2012).

Ken-ichi Nakashima, Masayoshi Oyama, Tetsuro Ito, Joko Ridho Witono, Dedy Darnaedi, Toshiyuki Tanaka, Jin Murata, Munekazu Iinuma. Novel zierane- and guaiane-type sesquiterpenes from the root of Melicope denhamii.


Mol. Nutr. Food. Res., 56, 713-724 (2012).

Kazuhiro Tsuruma, Hiroki Shimazaki, Ken-ichi Nakashima, Mika Yamauchi, Sou Sugitani, Masamitsu Shimazawa, Munekazu Iinuma, Hideaki Hara. Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo.


Tetrahedron, 68, 2421-2428 (2012).

Ken-ichi Nakashima, Masayoshi Oyama, Tetsuro Ito, Yukihiro Akao, Joko Ridho Witono, Dedy Darnaedi, Toshiyuki Tanaka, Jin Murata, Munekazu Iinuma. Novel quinolinone alkaloids bearing a lignoid moiety and related constituents in the leaves of Melicope denhamii.


Biol. Pharm. Bull., 35, 1-9 (2012).

Kotani Hitoshi, Tanabe Hiroki, Mizukami Hajime, Amagaya Sakae, Inoue Makoto. A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid X receptor (RXR) heterdimers.


J. Nutr. Sci. Vitaminol., 57, 426-431 (2011).

Shirakura Yoshiyuki, Takayanagi Katsuhiko, Mukai Katsuyuki, Tanabe Hiroki, Inoue Makoto. β-Cryptoxanthin suppresses the adipogenesis of 3T3-L1 cells via RAR activation.


Tetrahedron Lett., 52, 4694-4696 (2011).

Ken-ichi Nakashima, Masayoshi Oyama, Tetsuro Ito, Joko Ridho Witono, Dedy Darnaedi, Toshiyuki Tanaka, Jin Murata, Munekazu Iinuma. Melicodenines A and B, novel Diels–Alder type adducts isolated from Melicope denhamii.


Heterocycles, 83, 1603–1610 (2011).

Ken-ichi Nakashima, Masayoshi Oyama, Tetsuro Ito, Hiroko Murata, Munekazu Iinuma. New furanocoumarins from the fruits of Melicope triphylla.


J. Nat. Prod., 74, 634–638 (2011).

Hiroka Suzuki, Hiroki Tanabe, Hajime Mizukami, Makoto Inoue. Differential gene expression in rat vascular smooth muscle cells following treatment with coptisine exerts a selective antiproliferative effect.


J. Nat. Prod., 73, 1332–1336 (2010).

Hitoshi Kotani, Hiroki Tanabe, Hajime Mizukami, Makoto Makishima, Makoto Inoue. Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor (RXR).


Biol. Pharm. Bull., 33, 854-861 (2010).

Hiroshi Yokoi, Hajime Mizukami, Akito Nagatsu, Hiroki Tanabe, Makoto Inoue. Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors (PPARs).


Biol Pharm Bull, 33, 677-82 (2010).

Hiroka Suzuki, Hiroki Tanabe, Hajime Mizukami, Makoto Inoue. Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine.


Biol Pharm Bull, 32, 735-40 (2009).

Hiroshi Yokoi, Hajime Mizukami, Akito Nagatsu, Takamasa Ohno, Hiroki Tanabe, Makoto Inoue. Peroxisome proliferator-activated receptor gamma ligands isolated from adlay seed (Coix lacryma-jobi L. var. ma-yuen STAPF.).


Helv. Chim. Acta, 92, 1999-2008 (2009).

Ken-ichi Nakashima, Naohito Abe, Fumiko Kamiya, Tetsuro Ito, Masayoshi Oyama, Munekazu Iinuma. Novel flavonoids in dragon's blood of Daemonorops draco.


Biol. Sci. Space, 23, 85-97 (2009).

Ryutaro Izumi, Hirotaka Oishi, Akira Higashibata, Rika Yoshizaki, Isao Ito, Hirochika Murase, Makoto Inoue, Katsunori kato, Hitoshi Kawashima, Hideaki Soya, Noriaki Ishioka. Development of basic technologies for drop-tower experiment on vertebrates.


Chem. Pharm. Bull., 56, 173-175 (2008).

Kazuo Kojima, Takamasa Ohno, Makoto Inoue, Hajime Mizukami, Akito Nagatsu. Phellifuropyranone A: a new furopyranone compound isolated from fruit bodies of wild Phellinus linteus.


Drug Metab Dispos., 36, 1438-1443 (2008).

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue, Hajime Mizukami. Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury.


Biol. Pharm. Bull, 30, 1754-1757 (2007).

Munehiro Nakagawa, Takamasa Ohno, Rumi Maruyama, Munenori Okubo, Akito Nagatsu, Makoto Inoue, Hiroki Tanabe, Genzou Takemura, Shinya Minatoguchi, Hisayoshi Fujiwara. Sesquiterpene lactone suppresses vascular smooth muscle cell proliferation and migration via inhibition of cell cycle progression.


J. Nat. Med., 61. 438-442 (2007).

Takamasa Ohno, Yurika Takahashi, Hiroki Tanabe, Hideaki Hirayama, Hajime Mizukami, Yukio Ogihara, Makoto Inoue. Inhibitory effect of oral intake of natural Phellinus linteus fruit body on growth and pulmonary metastasis of B16/BL6 melanoma.


J. Nat. Med., 61, 342-348 (2007).

Nobukazu Ryu, Hiroki Tanabe, Toshiaki Makino, Hajime Mizukami, Makoto Inoue. Shosaikoto (a Kampo medicine) modulates changes in cytochrome P450 caused by Mycobacterium butyricum injection.


Biochem. Pharmacol., 74, 256-264 (2007).

Akira Matsumoto, Hajime Mizukami, Satoshi Mizuno, Keizo Umegaki, Jun-ichi Nishikawa, Koichi Shudo, Hiroyuki Kagechika and Makoto Inoue.  β-Cryptoxanthin, novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages.


Phytomed.., 13, 334-342 (2006).

Hiroki Tanabe, Hiroka Suzuki, Akito Nagatsu, Hajime Mizukami, Yukiko Ogihara, Makoto InoueSelective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizome, one of the crude drugs composing Kampo medicines Unsei-in.


Pharmacol. Res.., 54, 39-45 (2006).

Hai Yu, Kentaro Oh-Hashi, Tatsuhide Tanaka, Aihua Sai, Makoto Inoue, Yoko Hirata, Kazutoshi Kiuchi. Rehmannia glutinosa induces glial cell line-derived neurotrophic factor gene expression in astroglial cells via cPKC and ERK1/2 pathways independently.


 Eur. J. Pharmacol., 507, 301-310 (2005).

Nobuhiro Ohtake, Masahiro Yamamoto, Shuichi Takeda, Masaki Aburada, Atsushi Ishige, Kenji Watanabe, Makoto Inoue. The herbal medicine Sho-saiko-to exerts a selective inhibition of CD8+ T cell proliferation.


 J. Trad. Med., 22, 34-38 (2005).

Ayano Koizumi, Hajime Mizukami, Yukio Ogihara, Makoto Inoue M. Anti-atherosclerotic action of Saiko-Ka-Ryukotsu-Borei-To against ApoE-deficient mice.


Biol. Pharm. Bull., 28, 1731-1735 (2005).

Ayano Koizumi, Hajime Mizukami, Makoto Inoue. pX-gene causes hypercholesterolemia in hypercholesterolemia-resistant BALB/c mice.


Biochem. Pharmacol., 70, 1176-1184 (2005).

Hiroki Tanabe, Hiroka Suzuki, Hajime Mizukami, Makoto Inoue. Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells.


Tetrahedron Lett., 46, 8657-8660 (2005).

Takamasa Ohno, Akito Nagatsu, Munehiro Nakagawa, Makoto Inoue, Yun-Mo Li, Shinya Minatoguchi, Hajime Mizukami, Hisayoshi Fujiwara. New sesquiterpene lactones from water extract of the root of Lindera strychnifolia with cytotoxicity against the human small cell lung cell, SBC-3.


J Ethnopharmacol., 101, 215-220 (2005).

Mishima Satoshi, Kazu-michi Suzuki, Yoichiro Isohama, Naoko Kuratsu, Yoko Araki, Makoto Inoue, Takeshi Miyata. Royal jelly has estrogenic effects in viro and in vivo.



書籍

井上 誠

「薬学用語辞典」日本薬学会編

東京化学同人 (2012)


井上 誠

「現代医療における漢方薬」日本生薬学会監修

南江堂 (2008)


井上 誠

「漢方薬学(現代薬学性のための漢方入門)」奥田拓男編

廣川書店, (2008)


井上 誠

「新訂生薬学(改訂第6版)」木村孟淳、田中俊弘、水上元編

南江堂, pp131-140 (2007)


井上 誠

「最新生薬学」奥田拓男編

廣川書店, pp255-284 (2007)


その他

中島健一.薬草園をめぐる⑤ オウレンと初春に咲く花々

薬学図書館, 60, 107-108 (2015).


田中稔幸、大山雅義、阿部尚仁、中島健一.植物園で薬を探す

小石川植物園後援会ニュースレター, 48 (2014).


中島健一、大山雅義、飯沼宗和.ミカン科アワダン属植物の成分に関する研究

岐阜薬科大学紀要, 62. 38-47. (2013).


井上 誠.「機能性食品の安全性ガイドブック」津志田藤二郎、梅垣敬三、井上浩一、村上明編

SCIENCE FORUM, pp206-210

PAGE TOP

教員 大学院生等 6年生 5年生 4年生

論文・書籍 学会発表 その他

担当科目一覧 薬の歴史 生薬学 天然物化学

ギャラリー アクセス 薬学部HP 大学HP

生活習慣病や加齢性疾患に有効な天然薬物の基礎研究 天然由来核内受容体リガンドの探索及び応用研究 Unmet medical needsに応える漢方方剤の創製