最近の発表論文(Resent publications, 2012~2016)

誌上発表

2016

H Suzuki*, E Sasaki#, A Nakagawa#, Y Muraki, N Hatano & K Murak*. Diclofenac, a non-steroidal anti-inflammatory drug, is an antagonist of human TRPM3 isoforms. Pharmacol Res & Persp (in Press). *,#: equal contributions

Keypoint & 臨床との接点:鎮痛薬として汎用されるジクロフェナク(ボルタレン)がTRPM3チャネルの阻害作用を有することが明らかになりました!!

 

S. Ohya, H. Kito, N. Hatano & K. Muraki. Recent advances in therapeutic strategies that focus on the regulation of ion channel expression. Pharmacol & Therap 160, 11-43 (2016). Review Article

 

S Ohya, S Kanatsuka, N Hatano, H Kito, A Matsui, M Fujimoto, S Matsuba, S Niwa, P Zhan, T Suzuki & K Muraki. Downregulation of the Ca2+-activated K+ channel KCa3.1 by histone deacetylase inhibition in human breast cancer cells. Pharmacol Res & Persp 4(2), e00228 (2016).

 

Moilanen LJ, Hämäläinen M, Lehtimäki L, Nieminen RM, Muraki K & Moilanen E. Pinosylvin Inhibits TRPA1-Induced Calcium Influx In Vitro and TRPA1-Mediated Acute Paw Inflammation In Vivo. Basic Clin. Pharmacol. Toxicol. 118, 238-242 (2016).

Keypoint & 臨床との接点:松に含まれる生薬成分のピノシルビンがTRPA1チャネルの阻害作用を介して炎症性浮腫を抑制することが明らかになりました!!

 

J Naylor, A Minard, H Gaunt, M Amer, L Wilson, M Migliore, S Cheung, H Rubaiy, N Blythe, K Musialowski, M Ludlow, W Evans, B Green, H Yang, Y You, J Li, C Fishwick, K Muraki, D Beech & R Bon. Natural and synthetic flavonoid modulation of TRPC5 channels. Brit. J. Pharmacol., 173, 562-574 (2016).

Keypoint & 臨床との接点:プロポリスなどに含まれる生薬成分のガランジン(ガランギン)およびその新規誘導物質がTRPC4TRPC5チャネル阻害作用を有することを明らかにしました!!

2015

Y. Akbulut, H. Gaunt, K. Muraki, M. Ludlow, M. Amer, A. Bruns, N. Vasudev, L. Radtke, M. Willot, S. Hahn, T. Seitz, S. Ziegler, M. Christmann, D.  Beech & H. Waldmann.  (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angewandte Chemie Int. Ed., 54, 3787-3791 (2015). Hot paper

Keypoint & 臨床との接点:アフリカ産植物由来の(-)-Englerin ATRPC4チャネルの活性化を介して選択的に腎がんを抑制することが明らかになりました!!Innovations Report, Spotlight in ACS chemical biology, Chemical & Engineering Newsでも紹介されています)

 

K. Muraki, N. Hatano*, H. Suzuki*, Y Muraki*, Y. Iwajima, Y. Maeda & H. Ono. Oseltamivir blocks human neuronal nicotinic acetylcholine receptor-mediated currents. Basic Clin. Pharmacol. Toxicol., 11687-95 (2015). *: equal contributions

Keypoint & 臨床との接点:抗インフルエンザ薬のタミフルがヒトのニコチン性アセチルコリン受容体チャネルを直接抑制するを明らかにしました!!

2014

Li J, Hou B, Tumova S, Muraki K, Bruns A, et al. Piezo1 integration of vascular architecture with physiological force. Nature, 515, 279-282 (2014).

Keypoint & 臨床との接点:piezo1チャネルが血管内皮の力覚応答を介して血管発生に関わることが明らかになりました!!

 

K. Muraki & H. Ono. Human nicotinic acetylcholine receptor is a potential pharmacological target of oseltamivir. Receptors & Clin. Invest. Research Highlight, 1, e360 (2014).

 

S. Matsuba, S. Niwa, K. Muraki, S. Kanatsuka, Y. Nakazono, N. Hatano, M. Fujii, P. Zhan, T. Suzuki & S. Ohya. Downregulation of Ca2+-activated Cl- channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing cancer cells. J. Pharmacol. Exp. Therap., 351, 510-518 (2014).

 

H. Suzuki, N. Hatano, Y. Muraki, Y. Itoh, S. Kimura, H. Hayashi, K. Onozaki, Y. Ohi, A. Haji & K. Muraki. The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor. Am. J. Physiol., Cell-Physiol. 307, C384-C397 (2014).

 

2013

N. Hatano, H Suzuki, Y. Itoh & K. Muraki. TRPV4 partially participates in proliferation of human brain capillary endothelial cells. Life Sci., 92, 317-324 (2013).

N Hatano, H Suzuki, Y Muraki & K Muraki. Stimulation of human TRPA1 channels by clinical concentrations of the anti-rheumatic drug, auranofin. Am. J. Physiol., Cell-Physiol., 304, C354-C361 (2013).

 

2012

N Hatano, Y Itoh, H Suzuki, Y Muraki, H Hayashi, K Onozaki, IC Wood, DJ Beech & K Muraki. HIF1α switches on TRPA1 gene expression via a hypoxia response element-like motif to modulate cytokine release. J. Biol. Chem., 287, 31962-31972 (2012).

 

Yamamura H, S Ohya, K Muraki & Y Imaizumi. Involvement of inositol 1,4,5-trisphosphate formation in the voltage-dependent regulation of the Ca2+ concentration in porcine coronary arterial smooth muscle cells. J. Pharmacol. Exp. Therap., 342, 486-486 (2012).

 

Majeed, Y., S Tumova, B Green, V Seymour, D Woods, A Agarwal, J Naylor, S Jiang, H Picton, K Porter, D O’Regan, K Muraki, C Fishwick & D Beech. Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone. Cell Calcium, 55, 1-11 (2012). 二国間国際共同研究助成(日本学術振興会)成果