古野 忠秀 (ふるの ただひで)

プロフィール

1968年 滋賀県生まれ のどかな田舎町で生まれ育ちました。
1981年 息長小学校卒業 卒業の年は大雪(56豪雪)でした。
1984年 双葉中学校卒業 部活動(野球部)に励んでいました。卒業の年は大雪(59豪雪)でした。
1987年 彦根東高校卒業 ひたすら勉学に勤しみました(?)。いい友達に出会えました。
1991年 名古屋市立大学薬学部卒業 よく遊びました。運よく(?)薬剤師免許を取得できました。運よく面白い研究に出会えました。
1993年 名古屋市立大学大学院薬学研究科博士前期課程修了 薄暗い部屋で顕微鏡を使ってひたすらカルシウムイメージングをしていました。
名古屋市立大学薬学部助手 研究を続ける機会を得ることができました。
1997年 博士(薬学)を授与される 先生方、学生さんにお世話になりました。学位取得後、気持ちを新たに研究に取り組みました。
名古屋市立大学薬学部講師 日本バイオイメージング学会奨励賞を受賞することができました(1999年)。マクマスター大学健康科学部に留学しました(2002-2003年)。日本薬学会奨励賞を受賞することができました(2005年)。
2005年 愛知学院大学薬学部助教授 まっさらの状態から教育に研究に奮闘しました。
2007年 愛知学院大学薬学部准教授 立派な卒業生を送り出し、また、面白い研究をして、世の中の役に立てるよう微力ながら頑張っています。
2015年 愛知学院大学薬学部教授 教育に研究にさらに邁進しています。



研究業績

(英語原論文)

1) Nakato, K., Furuno, T., Inagaki, K., Teshima, R., Terao, T., Nakanishi, M.: Cytosolic and intranuclear calcium signals in rat basophilic leukemia cells as revealed by a confocal fluorescence microscope. Eur. J. Biochem., 209, 745-749. (1992)

2) Furuno, T., Isoda, R., Inagaki, K., Iwaki , T., Noji, M., Nakanishi,M.: A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells. Immunol. Lett., 33, 285-288. (1992)

3) Furuno, T., Hamano, T., Nakanishi, M.: Receptor-mediated calcium signal playing a nuclear third messenger in the activation of antigen-specific B cells. Biophys. J., 64, 665-669. (1993)

4) Furuno, T., Hamano, T., Nakanishi, M.: The effects of an inhibitor of the intracellular Ca2+ pump on nuclear calcium signals in B cells. Bioimages, 1, 9-12. (1993)

5) Furuno, T., Okamoto, Y., Hamano, T. Uehara, Y., Nakanishi, M.: Confocal fluorescence microscopy for studying the effects of a tyrosine kinase inhibitor on the nuclear calcium signals in B cells. Bioimages, 1, 175-180. (1993)

6) Teshima, R., Ikebuchi, H., Sawada, J., Furuno, T., Nakanishi, M., Terao, T.: Effects of herbimycin A and ST638 on Fcε receptor-mediated histamine release and Ca2+ signals in rat basophilic leukemia (RBL-2H3) cells. Biochim. Biophys. Acta, 1221, 37-46. (1994)

7) Horikoshi, Y., Furuno, T., Teshima, R., Sawada, J., Nakanishi, M.: Thapsigargin-induced nuclear calcium signals in rat basophilic leukemia cells. Biochem. J., 304, 57-60. (1994)

8) Suzuki-Nishimura, T., Furuno, T., Uchida, K. M., Nakanishi, M.: An initial signal of activation of rat peritoneal mast cells stimulated by Datura stramonium agglutinin: A confocal fluorescence microscopic analysis of intracellular calcium ion and cytoskeletal assembly. Jpn. J. Pharmacol., 66, 205-211. (1994)

9) Kato, E., Akiyoshi, K., Furuno, T., Nakanishi, M., Kikuchi, A., Kataoka, K., Sunamoto, J.: Interaction between ganglioside-containing liposome and rat T-lymphocyte: Confocal fluorescence microscopic study. Biochem. Biophys. Res. Commun., 203, 1750-1755. (1994)

10) Okamoto, Y., Furuno, T., Hamano, T., Nakanishi, M.: Confocal fluorescence microscopy for studying thapsigargin-induced bivalent-cation entry into B cells. Biochem. J., 305, 1011-1015. (1995)

11) Nakanishi, M., Furuno, T., Teshima, R.: Confocal fluorescence microscopy for studying signal transduction in mast cells and basophils. Zoological Studies, 34, 38-40. (1995)

12) Furuno, T., Teshima, R., Kitani, S., Sawada, J., Nakanishi, M.: Surface expression of CD63 antigen (AD1 antigen) in P815 mastocytoma cells by transfected IgE receptors. Biochem. Biophys. Res. Commun., 219, 740-744. (1996)

13) Okabe, T., Teshima, R., Furuno, T., Torigoe, C., Sawada, J., Nakanishi, M.: Confocal fluorescence microscopy for antibodies against a highly conserved sequence in SH2 domains. Biochem. Biophys. Res. Commun., 223, 245-249. (1996)

14) Sumida, M., Niwata, S., Tanaka, T., Furuno, T., Nakanishi, M., Wakabayashi, K., Boger, P.: Accumulation of protoporphyrinogen IX induced by acifluorfen methyl. Z. Naturforsch., 51c, 174-178. (1996)

15) Takeuchi, K., Ishihara, M., Kawaura, C., Noji, M., Furuno, T., Nakanishi, M.: Effect of zeta potential of cationic liposomes containing cationic cholesterol derivatives on gene transfection. FEBS Lett., 397, 207-209. (1996)

16) Ohyama, N., Furuno, T., Nakanishi, M.: Crossbridge rigidity acts differently on mIgM and IgE-mediated calcium signals. Bioimages, 4, 157-159. (1996)

17)  Shimizu , N., Kawazoe, Y., Furuno, T., Nakanishi, M.: Internalization of non-permeant materials into cultured mammalian cells by vortex-stirring in the presence of a high molecular weight polyacrylic acid : Direct evidence of internalization and its dependence on the cell lines. Biol. Pharm. Bull., 20, 727-731. (1997)

18) Nakanishi, M., Noji, M., Furuno, T., Kawaura, C., Nozaki, T.: Intracellular localization of antisense DNA transferred by cationic liposomes with a cationic cholesterol derivative. Cell Vision, 4, 128-129. (1997)

19) Kawaura, C., Furuno, T., Nakanishi, M.: AFM images of cationic liposomes complexed with plasmid DNA. Bioimages, 5, 121-125. (1997)

20) Kawaura, C., Noguchi, A., Furuno, T., Nakanishi, M.: Atomic force microscopy for studying gene transfection mediated by cationic liposomes with a cationic cholesterol derivative. FEBS Lett., 421, 69-72. (1998)

21) Noguchi, A., Furuno, T., Kawaura, C., Nakanishi, M.: Membrane fusion plays an important role in gene transfection mediated by cationic liposomes. FEBS Lett., 433, 169-173. (1998)

22) Nakamura, R., Furuno, T., Nakanishi, M.: Atomic force microscopy for the cellular localization of secretory granules and coated pits in rat basophilic leukemia cells after antigen stimulation. Bioimages, 6, 69-75. (1998)

23) Suzuki, M., Furuno, T., Teshima, R., Sawada, J., Nakanishi, M.: Soluble factors from rat basophilic leukemia cells stimulated cooperatively the neurite outgrowth of PC12 cells. Biol. Pharm. Bull., 21, 1267-1270. (1998)

24) Parashar, A., Akhand, A. A., Rawar, R., Furuno, T., Nakanishi, M., Kato, M., Suzuki, H., Nakashima, I.: Mercuric chloride induces increases in both cytoplasmic and nuclear free caicium ions through a protein phosphorylation-linked mechanism. Free Radic. Biol. Med., 26, 227-231. (1999)

25) Furuno, T., Ohyama, N., Nakanishi, M.: The relation between degranulation and rapid metabolic responses in RBL-2H3 cells. Biol. Pharm. Bull., 22, 310-312. (1999)

26) Tenjinbaru, K., Furuno, T., Hirashima, N., Nakanishi, M.: Nuclear translocation of green fluorescent protein-nuclear factor κB with a distinct lag time in living cells. FEBS Lett., 444, 1-4. (1999)

27) Suzuki, R., Furuno, T., McKay, D.M., Wolvers, D., Teshima, R., Nakanishi, M., Bienenstock, J.: Direct neurite-mast cell (RBL) communication in vitro occurs via the neuropeptide substance P. J. Immunol., 163, 2410-2415. (1999)

28) Teshima, R., Nakamura, R., Furuno, T., Nakanishi, M.: Degranulation in mast cells and basophils: Confocal and atomic force microscopy. Bioimages, 7, 97-103. (1999)

29) Dace, A., Zhao, L., Park, K.S., Furuno, T., Takamura, N., Nakanishi, M., West, B., Hanover, J.A., Cheng, S.Y.: Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors. Proc. Natl. Acad. Sci. USA., 97, 8985-8990. (2000)

30) Ohshiro, H., Suzuki, R., Furuno, T., Nakanishi, M.: Atomic force microscopy to study direct neurite-mast cell (RBL) communication in vitro. Immunol. Lett., 74, 211-214. (2000)

31) Suzuki, R., Furuno, T., Teshima, R., Nakanishi, M.: Bi-directional flow of in vitro mast cell-nerve communication observed by confocal laser scanning microscopy. Biol. Pharm. Bull., 24, 291-294. (2001)

32) Furuno, T., Hirashima, N., Onizawa, S., Sagiya, N. & Nakanishi, M.: Nuclear shuttling of mitogen-activated protein (MAP) kinase (extracellular signal-regulated kinase (ERK) 2) was dynamically controlled by MAP/ERK kinase after antigen stimulation in RBL-2H3 cells. J. Immunol., 166, 4416-4421. (2001)

33) Amano, T., Furuno, T., Hirashima, N., Ohyama, N. & Nakanishi, M.: Dynamics of intracellular granules with CD63-GFP in rat basophilic leukemia cells. J. Biochem., 129, 739-744. (2001)

34) Furukawa, Y., Furuno, T., Teshima, R., Nakanishi, M.: Calcium signals in rat basophilic leukemia (RBL-2H3) cells primed with the neuropeptide substance P. Biol. Pharm. Bull., 24, 1060-1063. (2001)

35) Ozaki, Y., Blomgren, K., Sugiura-Ogasawara, M., Aoki, K., Furuno, T., Nakanishi, M., Sasaki, M., Suzumori, K.: Role of calpain in human sperm activated by progesterone for fertilization. Biol. Chem., 382, 831-838. (2001)

36) Mizukoshi, T., Kodama, T. S., Fujiwara, Y., Furuno, T., Nakanishi, M., Iwai, S.: Structural study of DNA duplexes containing the (6-4) photoproduct by fluorescence resonance energy transfer. Nucleic Acids Res., 29, 4948-4954. (2001)

37) Noguchi, A., Hirashima, N., Furuno, T., Nakanishi, M.: Activation of receptor tyrosine kinases promotes gene transfection in rat neuronal PC12 cells by cationic liposomes. Neurosci. Lett., 325, 29-32. (2002)

38) Mori, N., Suzuki, R., Furuno, T., McKay, D.M., Wada, M., Teshima, R., Bienenstock, J., Nakanishi, M.: Neurite-mast cell (RBL) communication: RBL membrane ruffling is restricted to the specific site of contact with the activated neurite. Am. J. Physiol. Cell Physiol., 283, C1738-C1744. (2002)

39) Noguchi, S., Hirashima, N., Furuno, T., Nakanishi, M.: Remarkable induction of apoptosis in cancer cells by a novel cationic liposome complexed with a bcl-2 antisense oligonucleotide. J. Contol. Release, 88, 313-320. (2003)

40) Ohyama, N., Furuno, T., Hirashima, N., Nakanishi, M.: The effects of ITIM-bearing FcγRIIB on the nuclear shuttling of MAP kinase in RBL-2H3 cells. Immunol. Lett., 90, 173-176. (2003)

41) Furuno, T., Ma, D., van der Kleij, H. M. P., Nakanishi, M., Bienenstock, J.: Bone marrow-derived mast cells in mice respond in co-culture to scorpion venom activation of superior cervical ganglion neurites according to level of expression of NK-1 receptors. Neurosci. Lett., 372, 185-189. (2004)

42) Suzuki, A., Suzuki, R., Furuno, T., Teshima, R., Nakanishi, M.: N-cadherin plays a role in the synapse-like structures between mast cells and nerves. Biol. Pharm. Bull., 27, 1891-1894. (2004)

43) Furuno, T., Ito, A., Koma, Y., Watabe, K., Yokozaki, H., Bienenstock, J., Nakanishi, M., Kitamura, Y.: The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. J. Immunol., 174, 6934-6942. (2005)

44) Furuno, T., Nakanishi, M.: Live cell imaging to study signaling molecules in allergic reactions (review). Biol. Pharm. Bull., 28, 1551-1559. (2005)

45) Suzuki, A., Suzuki, R., Furuno, T., Teshima, R., Nakanishi, M.: Calcium response and FcεRI expression in bone marrow-derived mast cells co-cultured with SCG neurites. Biol. Pharm. Bull., 28, 1963-1965. (2005)

46) Furuno, T., Nakanishi, M.:Neurotrophic factors increase tumor necrosis factor-a-induced nuclear translocation of NF-κB in rat PC12 cells. Neurosci. Lett., 392, 240-244. (2006)

47) Kawamura, F., Hirashima, N., Furuno, T., Nakanishi, M.: The effects of 2-methyl-1,4-nephtoquinone (menadione) on cellular signaling in RBL-2H3 cells. Biol. Pharm. Bull., 29, 605-607. (2006)

48) Nakamura, R., Furuno, T., Nakanishi, M.: The plasma membrane shuttling of CAPRI is related to regulation of mast cell activation. Biochem. Biophys. Res. Commun., 347, 363-368. (2006)

49) Amano, K., Furuno, T., Nakanishi, M.: Conditioned medium from feeder STO cells increases the attachment of mouse embryonic stem cells. Biol. Pharm. Bull., 29, 1747-1750. (2006)

50) Ishihara, Y., Furuno, T., Nakanishi, M.: The role of phosphatidylinositol 4-kinase type IIα on degranulation from RBL-2H3 cells. Inflamm. Res., 55, 465-468. (2006)

51) Chikamatsu, S., Furuno, T., Kinoshita, Y., Inoh, Y., Hirashima, N., Teshima, R., Nakanishi, M.: Effects of Cot expression on the nuclear translocation of NF-κB in RBL-2H3 cells. Mol. Immunol., 44, 1490-1497. (2007)

52) Ueno, Y., Hirashima, N., Inoh, Y., Furuno, T., Nakanishi, M.: Characterization of biosurfactant-containing liposomes and their efficiency for gene transfection. Biol. Pharm. Bull., 30, 169-172. (2007)

53) Ueno, Y., Inoh, Y., Furuno, T., Hirashima, N., Kitamoto, D., Nakanishi, M.: NBD-conjugated biosurfactant (MEL-A) shows a new pathway for transfection. J. Control. Release, 123, 247-253. (2007)

54) Suzuki, R., Furuno, T., Okamoto, K., Teshima, R., Nakanishi, M.: ATP plays a role in neurite stimulation with activated mast cells. J. Neuroimmunol., 192, 49-56. (2007)

55) Obata, K., Furuno, T., Nakanishi, M., Togari, A.: Direct neurite-osteoblastic cell communication, as demonstrated by use of an in vitro co-culture system. FEBS Lett., 581, 5917-5922. (2007)

56) Kumagai, K., Ozaki, Y., Nakanishi, T., Inomata, M., Furuno, T., Nakanishi, M., Ogasawara, M. S.: Role of μ-calpain in human decidua for recurrent miscarriage. Am. J. Reprod. Immunol., 59, 339-346. (2008)

57) Koma, Y., Furuno, T., Hagiyama, M., Hamaguchi, K., Nakanishi, M., Masuda, M., Hirota, S., Yokozaki, H., Ito, A.: Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions. Gastroenterology, 134, 1544-1554. (2008)

58) Nakanishi, M., Furuno, T.: Molecular basis of neuroimmune interaction in an in vitro coculture approach (review). Cell. Mol. Immunol., 5, 249-259. (2008)

59) Sugimoto, Y., Furuno, T., Nakanishi, M.: Effect of NeuroD2 expression on neuronal differentiation in mouse embryonic stem cells. Cell Biol. Int., 33, 174-179. (2009)

60) Inoh, Y., Furuno, T., Hirashima, N., Nakanishi, M.: Non-viral vectors with a biosurfactant MEL-A promote gene transfection into solid tumors in mouse abdominal cavity. Biol. Pharm. Bull., 32, 126-128. (2009)

61) Nakanishi, M., Inoh, Y., Kitamoto, D., Furuno, T.: Nano vectors with a biosurfactant for gene transfection and drug delivery (review). J. Drug Deliv. Sci. Tech., 19, 165-169. (2009)

62) Miyazu, S., Furuno, T., Nakanishi, M.: Phosphorylation states of STAT3 and ERKs in mouse embryonic stem cells. Cell Biol. Int., 34, 485-492. (2010).

63) Hoshino, Y., Hirashima, N., Nakanishi, M., Furuno, T.: Inhibition of degranulation and cytokine production in bone marrow-derived mast cells by hydrolyzed rice bran. Inflamm. Res., 59, 615-625. (2010)

64) Inoh, Y., Furuno, T., Hirashima, N., Kitamoto, D., Nakanishi, M.: The ratio of unsaturated fatty acids in biosurfactants affects the efficiency of gene transfection. Int. J. Pharm., 398, 225-230. (2010)

65) Hagiyama, M., Furuno, T., Hosokawa, Y., Iino, T., Ito, T., Inoue, T., Nakanishi, M., Murakami, Y., Ito, A.: Enhanced nerve-mast cell interaction by a neuronal short isoform of cell adhesion molecule-1, CADM1. J. Immunol., 186, 5983-5992. (2011)

66) Furuno, T., Nakanishi, M.: A rational approach to inducing neuronal differentiation in embryonic stem cells, in Lovrecic, K. (Ed), Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis, InTech, pp429-444. (2011)

67) Furuno, T., Nakanishi, M.: Analysis of neuro-immune interactions by an in vitro co-culture approach, in Merighi, A. (Ed), Neuropeptides: Methods and Protocols, Methods in Molecular Biology vol. 789, Springer, pp171-180. (2011)

68) Inoh, Y., Furuno, T., Hirashima, N., Kitamoto, D., Nakanishi, M.: Rapid delivery of small interfering RNA by biosurfactant MEL-A-containing liposomes. Biochem. Biophys. Res. Commun., 414, 635-640. (2011).

69) Furuno, T., Nakanishi, M.: Kefiran suppresses antigen-induced mast cell activation. Biol. Pharm. Bull., 35, 178-183. (2012)

70) Takekawa, M., Furuno, T., Hirashima, N., Nakanishi, M.: Mitochondria take up Ca2+ in two steps dependently on store-operated Ca2+ entry in mast cells. Biol. Pharm. Bull., 35, 1354-1360. (2012)

71) Furuno, T., Hagiyama, M., Sekimura, M., Okamoto, K., Suzuki, R., Ito, A., Hirashima, N., Nakanishi, M.: Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3. J. Neuroimmunol., 250, 50-58. (2012)

72) Hagiyama, M., Inoue, T., Furuno, T., Iino, T., Itami, S., Nakanishi, M., Asada, H., Hosokawa, Y., Ito, A.: Increased expression of cell adhesion molecule 1 by mast cells as a cause of enhanced nerve-mast cell interaction in a hapten-induced mouse model of atopic dermatitis. Br. J. Dermatol., 168, 771-778. (2013)

73) Inoh, Y., Furuno, T., Hirashima, N., Kitamoto, D., Nakanishi, M.: Synergistic effect of a biosurfactant and protamine on gene transfection efficiency. Eur. J. Pharm. Sci., 49, 1-9. (2013)

74) Nakanishi, M., Inoh, Y., Furuno, T.: New transfection agents based on liposomes containing biosurfactant MEL-A (review). Pharmaceutics, 5, 411-420. (2013)

75) Nakamura, M., Inoh, Y., Nakanishi, M., Furuno, T.: Substance P is an important role in cell adhesion molecule 1-mediated nerve-pancreatic islet α cell interaction. Biochem. Biophys. Res. Commun., 438, 563-567. (2013)

76) Inoh, Y., Tadokoro, S., Tanabe, H., Inoue, M., Hirashima, N., Nakanishi, M., Furuno, T.: Inhibitory effects of a cationic liposome on allergic reaction mediated by mast cell activation. Biochem. Pharmacol., 86, 1731-1738. (2013)

77) Goto, S., Ozaki, Y., Suzumori, N., Yasukochi, A., Kawakubo, T., Furuno, T., Nakanishi, M., Yamamoto, K., Sugiura-Ogasawara, M.: Role of cathepsin E from decidual macrophages in patients with recurrent miscarriage. Mol. Hum. Reprod., 20, 454-462. (2014)

78) Obata, T., Suzuki, Y., Ogawa, N., Kurimoto, I., Yamamoto, H., Furuno, T., Sasaki, T., Tanaka, M.: Improvement of the antitumor activity of poorly soluble sapacitabine (CS-682) by using Soluplus as a surfactant. Biol. Pharm. Bull., 37, 802-807. (2014)

79) Furuno, T., Shinkai, N., Inoh, Y., Nakanishi, M.: Impaired expression of the mitochondrial calcium uniporter suppresses mast cell degranulation. Mol. Cell. Biochem., 410, 215-221. (2015)

80) Yokawa, S., Furuno, T., Suzuki, T., Inoh, Y., Suzuki, R., Hirashima, N.: Effect of cell adhesion molecule 1 expression on intracellular granule movement in pancreatic α cells. Cell Biochem. Biophys., 74, 391-398. (2016)

81) Iino, T., Hagiyama, M., Furuno, T., Ito, A., Hosokawa, Y.: Time-courses statistical evaluation of intercellular adhesion maturation by single-cell adhesion measurement using femtosecond laser impulse. Biophys. J., 111, 2255-2262. (2016)

82) Yokawa, S., Suzuki, T., Inouye, S., Inoh, Y., Suzuki, R., Kanamori, T., Furuno, T., Hirashima, N.: Visualization of glucagon secretion from pancreatic α cells by bioluminescence video microscopy: identification of secretion sites in the intercellular contact regions. Biochem. Biophys. Res. Commun., 485, 725-730. (2017)

83) Inoh, Y., Nagai, M., Matsushita, K., Nakanishi, M., Furuno. T.: Gene transfection efficiency into dendritic cells is influenced by the size of cationic liposomes/DNA complexes. Eur. J. Pharm. Sci., 102, 230-236. (2017)

84) Inoh, Y., Haneda, A., Tadokoro, S., Yokawa, S., Furuno, T.: Cationic liposomes suppress intracellular calcium ion concentration increase via inhibition of PI3 kinase pathway in mast cells. Biochim. Biophys. Acta. 1859, 2461-2466. (2017)

85) Watabe, K., Yokawa, S., Inoh, Y., Suzuki, T., Furuno, T.: Decreased intracellular granule movement and glucagon secretion in pancreatic α cells attached to superior cervical ganglion neurites. Mol. Cell. Biochem., 446, 83-89. (2018)

86) Yokawa, S., Suzuki, T., Hayashi, A., Inouye, S., Inoh, Y., Furuno, T.: Video-rate bioluminescence imaging of degranulation of mast cells attached to the extracellular matrix. Front. Cell Dev. Biol., 6, 74. (2018)

87) Shiki, A., Inoh, Y., Yokawa, S., Furuno, T.: Promotion of microtubule acetylation plays an important role in degranulation of antigen-activated mast cells. Inflamm. Res., 68, 181-184. (2019)

88) Kanki, H., Sasaki, T., Matsumura, S., Yokawa, S., Yukami, T., Shimamura, M., Sakaguchi, M., Furuno, T., Suzuki, T., Mochizuki, H.: β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in stroke. Cell Death Dis., 10, 100. (2019)

90) Shiki, A., Inoh, Y., Yokawa, S., Furuno, T.: Inhibition of degranulation in mast cells attached to a hydrogel through defective microtubule tracts. Exp. Cell Res., 381, 248-255. (2019)

91) Suzuki, R., Inoh, Y., Yokawa, S., Suzuki, R., Furuno, T., Hirashima, N.: Monomer hapten and hapten-specific IgG inhibit mast cell activation evoked by multivalent hapten with different mechanisms. Eur. J. Immunol., 49, 2172-2183. (2019)

92) Inoh, Y., Tsuchiya, Y., Nakanishi, Y., Yokawa, S., Furuno, T.: Involvement of intracellular caveolin-1 distribution in the suppression of antigen-induced mast cell activation by cationic liposomes. Cell Biol. Int., 44, 1068-1075. (2020)

93) Inoh, Y., Hirose, T., Yokoi, A., Yokawa, S., Furuno, T.: Effects of lipid composition in cationic liposomes on suppression of mast cell activation. Chem. Phys. Lipids, 231, 104948. (2020)

94) Goto, S., Ozaki, Y., Ozawa, F., Mizutani, E., Kitaori, T., Suzumori, N., Blomgren, K., Furuno, T., Sugiura-Ogasawara, M.: The investigation of calpain in human placenta with fetal growth restriction. Am. J. Reprod. Immunol., 85, e13325. (2021)

95) Suuki, R., Inoh ,Y., Yokawa, S., Furuno, T., Hirashima, N.: Receptor dynamics regulates actin polymerization state through phosphorylation of cofilin in mast cells. Biochem. Biophys. Res. Commun., 534, 714-719. (2021)

96) Sugimoto, H., Fukuda, S., Yokawa, S., Hori, M., Ninomiya, H., Sato, T., Miyazawa, K., Kawai, T., Furuno, T., Inouye, S., Goto, S., Suzuki, T.: Visualization of osteocalcin and bone morphogenetic protein 2 (BMP2) secretion from osteoblastic cells by bioluminescence imaging. Biochem. Biophys. Res. Commun., 635, 203-209. (2022)

97) Kawakubo, M., Inoh, Y., Inaguma, Y., Kokubugata, R., Murata, Y., Matsumura, M., Furuno, T., Yasuike, S.: Synthesis and intracellular localization of 5,6-disubsutituted pyrido[1’,2’;2,3]imidazo[5,1-a]isoquinolinium Iodides. ChemistrySelect, 8, e202303017. (2023)

98) Kawakubo, M., Inoh, Y., Murata, Y. Matsumura, M., Furuno, T., Yasuike S.: Novel mono substituted pyridoimidazoisoquinoliniums via a silvercatalyzed intramolecular cyclization and their applications in cellular imaging. RSC Adv., 14, 9758. (2024)



(日本語)

1) 中西 守、古野忠秀:細胞膜から核へのシグナル.細胞工学, 12, 595-598. (1993)

2) 古野忠秀、中西 守:リンパ球のCa2+動態.新しい光学顕微鏡(第2巻) pp146-148. (1995)

3) 中西 守、古野忠秀、長尾陽子:単一細胞における細胞内カルシウム測定法(免疫細胞).細胞内カルシウム研究プロトコール(実験医学別冊) pp152-158. (1996) 

4) 古野忠秀:トレース分子、ケージド化合物.見る技術(蛋白質 核酸 酵素増刊号) pp1122-1127. (1997)

5) 中村亮介、古野忠秀、中西 守:免疫系における細胞間相互作用.日本物理学会誌, 53, 2-6. (1998)

6) 古野忠秀、中西 守:リンパ球におけるカルシウムイメージング.細胞, 30, 11-14. (1998)

7) 古野忠秀:ストレス応答とカルシウム動態.放射線科学, 41, 49-53. (1998)

8) 中西 守、古野忠秀:花粉症とアレルギー反応 −分子レベルでの解明−.薬局, 49, 455-460. (1998)

9) 古野忠秀、中西 守:細胞のアポトーシスのイメージング.バイオイメージングの最先端, pp161-165. (1999)

10) 古野忠秀、中西 守:細胞内シグナル分子の可視化解析.生物物理, 43, 218-222. (2003)

11) 古野忠秀:顕微光学法によるマスト細胞活性化の分子機構の研究.薬学雑誌, 125, 671-683. (2005)

12) 中西 守、古野忠秀:免疫反応の利用.スタンダード薬学シリーズ4 生物系薬学III 生体防御, pp132-143. (2006)

13) 古野忠秀、中西 守:細胞工学的手法.生物物理学ハンドブック, pp632-634. (2007)

14) 中西 守、古野忠秀:分子イメージング法による細胞内情報伝達機構の研究.薬品分析科学の最前線, pp172-173. (2009)

15) 中西 守、古野忠秀:肥満細胞と感覚神経の接着におけるCADM1とネクチン-3の関与.生体の科学,64, 216-219. (2013)


メンバーのページへ

薬品分析学講座のホームページへ

愛知学院大学薬学部のホームページへ